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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.

Sec. Clinical and Diagnostic Microbiology and Immunology

Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1615182

This article is part of the Research TopicCommunity Series in the Immunological Role of the Maternal Microbiome in Pregnancy: Volume IIView all 6 articles

Endometrial microbiome during early pregnancy among women with and without chronic endometritis: A pilot study

Provisionally accepted
Hong GaoHong Gao1Na LuNa Lu2Yahui ChenYahui Chen2Li GenlinLi Genlin3Huanhuan LiHuanhuan Li1Innie ChenInnie Chen4Amanda BlackAmanda Black5Jenna GaleJenna Gale4Daniel CorsiDaniel Corsi4Xiaolan WangXiaolan Wang3Kristin ConnorKristin Connor6Shi Wu WenShi Wu Wen4*
  • 1Second Affiliated Hospital of University of South China, Hengyang, Hunan Province, China
  • 2School of Nursing, University of South China, Hengyang, Hunan Province, China
  • 3The First Affiliated Hospital, University of South China, Hengyang, Hunan Province, China
  • 4Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada
  • 5Department of Obstetrics and Gynecology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
  • 6Department of Health Sciences, Faculty of Science, Carleton University, Ottawa, Ontario, Canada

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Do the composition and relative abundance of endometrium microbiome during early pregnancy in women with chronic endometritis differ from those women without chronic endometritis?The endometrium microbiome composition in pregnant women with chronic endometritis was similar with those women without chronic endometritis, but the relative abundance of these microbes between the two groups was significantly different.A stable endometrial microbiome composition in women with chronic endometritis may be crucial for their ability to conceive, whereas the dysbiotic shifts in microbial abundance may be linked to poorer pregnancy outcomes.

Keywords: endometrial microbiome, Chronic endometritis, early pregnancy, 16S rRNA, host factors

Received: 20 Apr 2025; Accepted: 24 Jul 2025.

Copyright: © 2025 Gao, Lu, Chen, Genlin, Li, Chen, Black, Gale, Corsi, Wang, Connor and Wen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Shi Wu Wen, Ottawa Hospital Research Institute (OHRI), Ottawa, K1Y 4E9, Ontario, Canada

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material