ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1616995
Global research trends on the interaction between gut microbiome and bile acids: a bibliometric and visualized analysis
Provisionally accepted
- 1Clinical School of Integrated Traditional Chinese and Western Medicine, North Sichuan Medical University, Nanchong, Anhui Province, China
- 2College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 3Department of Traditional Chinese Medicine, Chengdu Wenjiang District Maternal and Child Health Hospital, Chengdu, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Abstract Background: An increasing number of studies have shown that gut microbiome-bile acids interactions play a crucial role in host health and disease. This bibliometric analysis aims to identify the global scientific output, research hotspots, and frontiers of gut microbiome-bile acids in the past two decades. Methods: We searched the relevant studies of gut microbiome-bile acids published between 2004 and 2024 in the Web of Science Core Collection database. Microsoft Excel 2019, VOSviewer 1.6.18, Tableau Desktop 2024.2.2, Scimago Graphica 1.0.45, and CiteSpace 6.2.R3 were used to analyze the publications, countries/regions, institutions, journals, authors, references, and keywords. Results: A total of 4795 original articles and reviews were collected. A visual analysis of the results showed that the number of publications increased rapidly over time. China published the most papers, the United States had the most citations, and the most productive institution was Shanghai Jiaotong University. The most prolific author was Jia Wei, and Jason M. Ridlon was the most frequently co-cited author. Nutrients was the most productive journal. In the keyword co-occurrence network, except for gut microbiome and bile acids, inflammation becomes the keyword with the highest frequency. Keywords and reference analysis show that metabolic diseases (such as obesity and type 2 diabetes mellitus), cancer (such as colorectal cancer), and disease-related mechanisms (such as tgr5 and pathway) are the hot topics and future research trends in this field. Conclusion: In this study, bibliometric analysis was utilized to explore the relationship between gut microbiome and bile acids. The findings can reflect the current hotspots and new directions of gut microbiome-bile acids, and provide an objective description and comprehensive guidance for future related studies.
Keywords: Bibliometrics, gut microbiome, Bile acids, Citespace, VOSviewer, visualization bibliometrics, visualization
Received: 23 Apr 2025; Accepted: 10 Jul 2025.
Copyright: © 2025 Luo, Sun, Wan, Tian and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fangli Luo, Clinical School of Integrated Traditional Chinese and Western Medicine, North Sichuan Medical University, Nanchong, Anhui Province, China
Zhaoxuan He, College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.