ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Clinical Microbiology
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1618846
This article is part of the Research TopicAdvances in Vaginal Microbiome and Metabolite Research: Genetics, Evolution, and Clinical PerspectivesView all 8 articles
Association Between Vaginal Microecological Alterations and High-Risk Human Papillomavirus Infection: A Cross-Sectional Study
Provisionally accepted
- 1Shanghai University of Medicine and Health Sciences, Shanghai, China
- 2Xuhui District Center for Disease Control and Prevention, Shanghai, China
- 3Clinical Laboratory, Wusong Central Hospital, Baoshan District, shanghai, China
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This study aimed to investigate the correlation between alterations in the vaginal microecological environment and high-risk human papillomavirus (HR-HPV) infection, thereby providing a theoretical basis for clinical prevention and early intervention. Methods A total of 854 patients who visited the gynecology outpatient clinic at Wusong Central Hospital, Baoshan District, Shanghai, between June and December 2023 were included. Vaginal secretions were collected for HPV genotyping and microecological analysis. Patients were categorized into HR-HPV-positive (n=222) and HR-HPV-negative (n=632) groups. The detection rates of various HR-HPV subtypes (
Keywords: No. 101, Tongtai North Road, Baoshan District, Shanghai Vaginal microecology, High-risk HPV infection, cervical cancer, correlation study, Early Intervention
Received: 27 Apr 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Peng, Xiao, He and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Nanqiu Peng, Shanghai University of Medicine and Health Sciences, Shanghai, China
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