ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Extra-intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1622552
Analysis of Microbiotas between Traumatic and Ulcerative Wound: Insights into Challenges of Current Wounds Managements
Provisionally accepted
- 1West China Second University Hospital, Sichuan University, Chengdu, China
- 2sichuan university, Chengdu, China
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Objective: Wounds frequently occur during daily activities and clinical treatments, exerting substantial impacts on patients' health status and recovery processes.Methods: All the patients were enrolled for this analysis from January 2022 to December 2022 who received wound management at Wound Care Center, West China Hospital, Sichuan University, which was a single center, prospectively designed observational study. In this investigation, microbial samples were collected from 106 traumatic wounds and 157 ulcerative wounds and analysed by 16S rRNA gene sequencing.The findings revealed distinct differences in the microbial composition and function between traumatic and ulcerative wounds. Specifically, ulcerative wounds exhibited significantly higher abundances of infection-and pro-inflammation-related microbes, such as Corynebacterium auriscanis, Finegoldia magna, and Corynebacterium striatum, whereas traumatic wounds had a significantly elevated abundance of Bifidobacterium longum, which is known to promote wound healing.Regarding functional profiles, the relative abundances of lipopolysaccharide (LPS) biosynthesis, fatty acid biosynthesis, and metabolism of xenobiotics by cytochrome P450 were notably higher in the traumatic wound group. In contrast, the ulcerative wound group showed significantly greater relative abundances of drug metabolismother enzymes, folate biosynthesis, and cysteine and methionine metabolism.Comparative analyses of the microbial communities in wounds reveled that traumatic wounds, especially non-postoperative wounds, were more easily to heal, however, the ulcerative wounds, especially the non-venous wounds, were more difficult to heal. These results suggest that different types of wounds harbor distinct microbial compositions, providing valuable data to inform improved clinical wound management strategies.
Keywords: wound, Microbial composition, Traumatic wound, Ulcerative wound, Outcome
Received: 06 May 2025; Accepted: 12 Aug 2025.
Copyright: © 2025 Li, Chen, Wang, Fan and Dai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yifei Li, West China Second University Hospital, Sichuan University, Chengdu, China
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