BRIEF RESEARCH REPORT article
Front. Cell. Infect. Microbiol.
Sec. Clinical Infectious Diseases
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1625007
This article is part of the Research TopicPerspectives in Clinical Infectious Diseases: 2024/2025View all 9 articles
A breakthrough Trichosporon asahii infection in an immune thrombocytopenia patient during caspofungin and isavuconazole combined therapy: A case report
Provisionally accepted
- Department of Critical Care Medicine, Qilu Hospital (Qingdao), Shandong University, Qingdao, China
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Trichosporon infection is a rare but highly lethal infectious disease. Clinically, Trichosporon asahii is the strain most commonly isolated from patients with Trichosporon infections. T. asahii is an opportunistic pathogen that can cause local or invasive infections in immunocompromised patients. In this article, a case of breakthrough T. asahii infection in an immune thrombocytopenia (ITP) patient during caspofungin and isavuconazole combined therapy is reported. Metagenomic next-generation sequencing (mNGS) played a crucial role in the diagnosis of the breakthrough infection in this patient. Upon receiving combined therapy with intravenous voriconazole and nebulized amphotericin B, the patient demonstrated significant clinical improvement and was subsequently discharged.
Keywords: Trichosporon asahii, Breakthrough invasive fungal infections, Isavuconazole, metagenomic next-generation sequencing, caspofungin
Received: 08 May 2025; Accepted: 09 Jul 2025.
Copyright: © 2025 Lu, Sun, Li, Yingjie, Wu, Li and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhi Li, Department of Critical Care Medicine, Qilu Hospital (Qingdao), Shandong University, Qingdao, China
Xi Guo, Department of Critical Care Medicine, Qilu Hospital (Qingdao), Shandong University, Qingdao, China
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