EDITORIAL article

Front. Cell. Infect. Microbiol.

Sec. Intestinal Microbiome

Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1629822

This article is part of the Research TopicThe microbiome in surgery - friend or foe?View all 9 articles

Editorial: The Microbiome in Surgery -Friend or Foe?

Provisionally accepted
  • 1Department of General-, Visceral- and Transplantsurgery, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany
  • 2Department of General and Visceral Surgery, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
  • 3Institute of Medical Microbiology and Hygiene, Medical Center–University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

The final, formatted version of the article will be published soon.

The human microbiome, an ever-changing consortium of microorganisms found at numerous body 12 sites, plays a pivotal role in health and disease. Surgical interventions, while lifesaving, exert 13 significant physiological stress and can disrupt microbial homeostasis, influencing recovery, infection 14 rates, and overall outcomes. 15This research topic aimed to elucidate the delicate balance between surgery and the microbiome, 16 highlighting both the beneficial and detrimental impacts of microbes to the surgical environment. The 17 contributions within this collection provide compelling evidence of how microbial communities 18 influence surgical outcomes, and how surgical practices, such as the use of antibiotics and specific 19 procedures, affect microbial balance. 20 Biesel et al. 1

Keywords: microbiota, Surgery, Postoperative Complications, Host microbial interaction, Immunomodulation, Outcome

Received: 16 May 2025; Accepted: 09 Jun 2025.

Copyright: © 2025 Lederer, Chikhladze and Badr. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Ann-Kathrin Lederer, Department of General-, Visceral- and Transplantsurgery, University Medical Center Mainz, Johannes Gutenberg University Mainz, Mainz, Germany

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