ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Parasite and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1642716
A novel YGGT family protein is localized in the apicoplast and is essential for the organelle inheritance
Provisionally accepted
- State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, China
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Toxoplasma gondii is an obligate intracellular apicomplexan parasite.Most apicomplexan parasites contain an endosymbiont-derived organelle called the apicoplast. This organelle is critical for the survival of parasites because it plays a role in several essential metabolic pathways. However, the molecular mechanisms involved in maintaining the apicoplast have not been well understood. In this study, we investigated the function of an apicoplast-residing protein called TgYCAP in the inheritance of the apicoplast.Our results showed that conditional knockdown of TgYCAP severely inhibited the growth of the parasite and disrupted the inheritance of the apicoplast. In addition, the YGGT domain is essential for its function in the apicoplast.
Keywords: Toxoplasma gondii, apicoplast, Biogenesis, YGGT family protein, TgYCAP
Received: 07 Jun 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Su, Gu, Zheng and Jia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Honglin Jia, State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, CAAS, Harbin, China
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