ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Oral Microbes and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1659042
This article is part of the Research TopicImpact of oral and gut microbiome on health and diseasesView all 25 articles
Exploring the Influence of Psychological Factors on the Comorbidity of Dental Caries and Obesity in Adolescents from the Perspective of the Oral-Gut-Brain Axis
Provisionally accepted
Meng Wang1,2Xiaopeng Yang3Yimin Li1,2,3Mingxin Jiang1,2,3Bairu Chen1,2,3Wei Yang1,2,3
Nan Ma1,2,3,4Shili He1,2,3
Chengyue Wang1,2,3*- 1Jinzhou Medical University School of Stomatology, Jinzhou, China
- 2Collaborative Innovation Center for Health Promotion of Children and Adolescents of Jinzhou Medical University, Jinzhou, China
- 3Stomatology Hospital Affiliated of Jinzhou Medical University, Jinzhou, China
- 4School and Hospital of Stomatology, China Medical University, Shenyang, China
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This study explores the impact of psychological factors on the comorbidity of dental caries and obesity in adolescents through the oral-gut-brain axis. An epidemiological survey was conducted on 1,024 students from Beizhen No. 1 Junior High School, with 90 adolescents aged 12–15 included in biosample research. Methods such as 16S rRNA gene sequencing, untargeted metabolomics, and SourceTracker analysis were used. Results showed significant differences in oral and gut microbiota and metabolite concentrations among adolescents with different health statuses, highlighting the roles of the oral-gut and oral-brain axes in disease progression. This study provides new insights into the mechanisms underlying the comorbidity of dental caries and obesity in adolescents and offers theoretical foundations for prevention and treatment strategies.
Keywords: Oral-gut-brain axis, caries, Obesity, adolescents, microbiota
Received: 03 Jul 2025; Accepted: 19 Aug 2025.
Copyright: © 2025 Wang, Yang, Li, Jiang, Chen, Yang, Ma, He and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chengyue Wang, Jinzhou Medical University School of Stomatology, Jinzhou, China
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