REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Virus and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1661155
This article is part of the Research TopicPerspectives in Virus and Host: 2025View all 9 articles
Advance in Molecular Mechanisms Underlying Diabetes Related to Viral Hepatitis Infection
Provisionally accepted
- 1The First Hospital of Jilin University, Changchun, China
- 2Jilin University School of Public Health, Changchun, China
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Diabetes and viral hepatitis, particularly hepatitis B (HBV) and hepatitis C (HCV), are significant global health burdens with complex interconnections. This review discusses the molecular mechanisms linking viral hepatitis to diabetes, focusing on inflammatory pathways, oxidative stress, and epigenetic modifications. Key findings highlight the role of STAT3 in promoting insulin resistance and β-cell apoptosis, the impact of ER stress and NOX-mediated oxidative stress on metabolic dysfunction, and the influence of epigenetic changes such as DNA methylation and histone acetylation on glucose homeostasis. These interconnected pathways provide insights into the pathogenesis of diabetes in hepatitis patients and suggest potential therapeutic targets for managing these co-occurring conditions. Future research directions include exploring the synergistic effects of these pathways and leveraging
Keywords: Viral Hepatitis, diabetes, Oxidative Stress, epigenetic modifications, inflammatory pathways
Received: 07 Jul 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Wang, Yu, Che, Du, Xu, Niu and Chi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiumei Chi, The First Hospital of Jilin University, Changchun, China
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