MINI REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Bacteria and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1662511
This article is part of the Research TopicAutophagy Evasion by Intracellular Pathogens: Mechanistic InsightsView all articles
Emerging interplays between poxviruses and autophagy
Provisionally accepted
- 1College of Life Sciences, Nankai University, Tianjin, China
- 2School of Basic Medical Sciences, Shandong University, Jinan, China
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Poxviruses are large double-stranded DNA viruses that replicate exclusively in the cytoplasm. Their life cycle is closely associated with various membrane-related cellular processes. This review summarizes current findings on the complex interplay between poxviruses and autophagy, as well as the endo-lysosomal network. However, due to the large diversity of poxvirus species and the limited number of relevant studies, it remains challenging to draw definitive conclusions regarding the bidirectional regulatory relationship between poxviruses and the autophagy-lysosome system. In addition, poxviruses can serve as a promising platform for oncolytic virus development.Furthermore, we also highlight recent studies leveraging autophagy modulation to enhance the therapeutic efficacy of oncolytic poxviruses. Thus, elucidation of the interplay between poxviruses and autophagy-lysosome pathway will not only advance the understanding of virology and cell biology, but also facilitate the engineering of oncolytic poxviruses as innovative tools for cancer therapy.
Keywords: poxvirus, Autophagy, Lysosome, virus-host interaction, oncolytic virus, Monkeypox virus
Received: 09 Jul 2025; Accepted: 12 Aug 2025.
Copyright: © 2025 Li, Miao, Jia and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rui Jia, School of Basic Medical Sciences, Shandong University, Jinan, China
Ruikang Liu, College of Life Sciences, Nankai University, Tianjin, China
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