ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Antibiotic Resistance and New Antimicrobial drugs
This article is part of the Research TopicAdvances in Combating Antimicrobial Resistance: Focus on Diagnosis, Therapy, and PreventionView all 8 articles
Multi-drug resistant Clostridioides difficile isolate ST81 is prominent in hematological patients in a teaching hospital in China
Provisionally accepted
Qi Zhao1
Yaoqian Bian2XinJun Wei3
Shuzhen Xiao4Zizhen Xu4,5Hui Li4,5Qingtian Li4,5Beiwen Wei4,5Jiewen Huang4,5Zhen Song4,5*
Yanan Zhao4,5*- 1Department of Laboratory Medicine, Qingdao University Medicine College Affiliated Yantai Yuhuangding Hospital, Yantai, China
- 2Department of Laboratory Medicine，Dachang Hospital of Baoshan District of Shanghai, Shanghai, China
- 3Department of Laboratory Medicine，The Eighth People's Hospital of Qingdao, Qindao, China
- 4Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- 5College of Health Sciences and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Clostridioides difficile Infection (CDI) is more prevalent in people with hematologic diseases. However, epidemiological characteristics are poorly understood. From July 2016 to November 2021, we studied the epidemiology of CDI in patients with hematological diseases at a tertiary teaching hospital in Shanghai, China. In hematological patients, the prevalence of CDI was 21.6%, with 89.8% hospital-acquired infections. C. difficile ST81, which is a multidrug-resistant strain carrying only the toxin B, is the most common strain (38.1%), followed by ST3 (16.7%) and ST2 (9.5%). Clindamycin and moxifloxacin resistance rates of all C. difficile species were 64.3% and 31%, respectively, and no isolate was resistant to vancomycin, linezolid, metronidazole, teicoplanin, or daptomycin. This study provides a comprehensive characterization of CDI in hematological patients, highlighting the urgent need for enhanced surveillance and preventive strategies against this emerging nosocomial threat.
Keywords: Clostridioides difficile, Hematologic Diseases, genotyping, Epidemiology, Drugresistance
Received: 18 Jul 2025; Accepted: 17 Nov 2025.
Copyright: © 2025 Zhao, Bian, Wei, Xiao, Xu, Li, Li, Wei, Huang, Song and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhen Song, sz40597@rjh.com.cn
Yanan Zhao, 184479@shsmu.edu.cn
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