MINI REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Oral Microbes and Host
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1669490
This article is part of the Research TopicImpact of oral and gut microbiome on health and diseasesView all 29 articles
Association Between Periodontal Disease and Prostate Disease: A Mini Review
Provisionally accepted
- 1Jilin University, Changchun, China
- 2Sichuan University, Chengdu, China
- 3Yanbian University Medical College, Yanji, China
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Periodontal disease (PD) is one of the most common chronic diseases in the oral cavity, typically referring to chronic inflammation caused by infection with pathogenic microorganisms in the oral cavity. PD primarily affects the tissues surrounding the teeth, leading to inflammation of the gums and periodontal tissues, destruction of the alveolar bone, and even loosening of the teeth. Numerous studies have shown that PD is not limited to the oral cavity but is also associated with the occurrence of diseases in multiple systems throughout the body. In recent years, increasing attention has been directed toward the interaction between PD and prostate diseases. This article reviews the potential associations between PD and prostate conditions such as chronic prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa). It explores the pathological mechanisms underlying this interaction and its clinical implications. Additionally, this article aims to identify potential pathogenic mechanisms and propose possible approaches for preventing and treating prostate diseases through the management of PD.
Keywords: Periodontal disease, Oral microbiota, prostate cancer, Benign prostatic hyperplasia, Prostatitis, systemic inflammation, Inflammatory factors
Received: 19 Jul 2025; Accepted: 26 Sep 2025.
Copyright: © 2025 Li, Cao, Zhang, Yang, Li, Lv and Lian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xin Lian, lianxin6216163@163.com
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