REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Biofilms
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1669643
This article is part of the Research TopicNovel Strategies for Caries ControlView all 7 articles
Recent Progress in Antimicrobial Strategies of Controlled-Release Nanomaterials for Secondary Caries
Provisionally accepted
- 1Zhengzhou University, Zhengzhou, China
- 2Stomatological Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- 3Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, zhengzhou, China
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Secondary caries is a leading cause of restoration failure. Inhibiting caries through antimicrobial efficacy is essential for extending the restoration's service life. Antimicrobial agents have been incorporated into restorative materials for decades. Based on their mechanism of antimicrobial action, these materials are classified as either releasing or non-releasing types. However, the simple release strategy is often insufficient for long-term caries prevention, as it lacks the precision, durability, and adaptability now required. This necessitates the development of next-generation systems that can provide a controlled, sustained, and targeted antimicrobial activity. To this end, this review focuses on advanced, controlled-release antimicrobial strategies, exploring the design of novel nanomaterials, their functional efficacy, and the mechanisms of their representative antimicrobial agents.
Keywords: antimicrobial, nanomaterials, controlled-release, Stimulus-responsive, Rechargeable, cascade catalytic nanoreactor, Secondary caries
Received: 20 Jul 2025; Accepted: 08 Sep 2025.
Copyright: © 2025 Wang, Du, Jia, Qin, Liu, Cai and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fei Liu, Stomatological Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Yingchun Cai, Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, zhengzhou, China
Suping Wang, Stomatological Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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