ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1674551
This article is part of the Research TopicExploring the Gut Microbiota-Host Interaction through Omics: From Metabolite Profiling to Therapeutic StrategiesView all 3 articles
Lacticaseibacillus paracasei FJG2337 mitigate acute liver injury-related inflammatory responses, gut microbiota and liver metabolism in mice
Provisionally accepted
- 1The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
- 2Fuzhou University, Fuzhou, China
- 3Other
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Acute liver injury (ALI) has a high global prevalence but limited and suboptimal treatment options. Probiotics can help improve liver function by regulating gut microbiota, suppressing inflammatory responses, and inhibiting oxidative stress. However, substantial variations exist in the hepatoprotective efficacy of different bacterial strains. Lacticaseibacillus paracasei FJG2337 was isolated from the feces of long-lived elderly individuals, but its potential hepatoprotective effects remain unclear. In the present study, the influence of L. paracasei FJG2337 on the liver function in lipopolysaccharide (LPS)-treated mice was investigated. Our data demonstrated that L. paracasei FJG2337 ameliorated the serum parameters (including ALT, AST, and ALP) and elevated cecal short-chain fatty acids contents in mice with ALI. L. paracasei FJG2337 pre-treatment suppressed inflammatory responses and oxidative stress in ALI mice through modulating the TLR4/NF-кB and Nrf2/HO-1 pathway, respectively. Furthermore, L. paracasei FJG2337 significantly elevated the abundance of beneficial bacteria in mice and significantly reduced the harmful bacteria populations. Metabolomics analysis displayed that L. paracasei FJG2337 ameliorated liver metabolism in ALI mice, primarily affecting tryptophan metabolism, arachidonic acid metabolism, retinol metabolism, and glutathione metabolism, and so on. These results highlight that L. paracasei FJG2337 could serve as a promising probiotic intervention for patients with liver function injury.
Keywords: Lacticaseibacillus paracasei, inflammatory responses, Oxidative Stress, Gut Microbiota, Liver metabolism
Received: 28 Jul 2025; Accepted: 07 Oct 2025.
Copyright: © 2025 He, Yang, Guo, Ou, Lv and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Weiling Guo, 609969791@qq.com
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