REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Antibiotic Resistance and New Antimicrobial drugs
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1676009
This article is part of the Research TopicTargeting Major Human Fungal Pathogens: Novel Insights into Virulence and Antifungal TherapiesView all 10 articles
Recent Innovations and Challenges in the Treatment of Fungal Infections
Provisionally accepted
- Army Medical University Xinqiao Hospital, Chongqing, China
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The prevalence of fungal infections has been increasing consistently in recent years, particularly among immunocompromised individuals, resulting in increased mortality. The World Health Organization now lists "super fungi," such as Candida auris as global public health threats, highlighting the urgent requirement for new antifungal therapies. Although conventional agents such as azoles and polyenes remain prevalent in medical treatment, challenges including drug resistance, limited selectivity, and high toxicity limit their value, prompting the need for the development of more effective therapeutic strategies. Current research trends are shifting towards multi-mechanistic combination therapies and biotechnology-driven approaches, which demonstrate significant potential. This review summarizes recent advances and outlines directions for future antifungal drug development and new therapies.
Keywords: Fungal infections, Antifungal drugs, combination therapy, biotechnology-driven approaches, Drug Development
Received: 29 Jul 2025; Accepted: 18 Sep 2025.
Copyright: © 2025 Liu, Zhou and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: XinDi Gao, 18940091334@163.com
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