ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1677726
This article is part of the Research TopicExploring the Gut Microbiota-Host Interaction through Omics: From Metabolite Profiling to Therapeutic StrategiesView all articles
Microbiomics and metabolomics explored the characteristics of gut microbiota and metabolites in patients with aortic dissection
Provisionally accepted
- Fujian Medical University Union Hospital, Fuzhou, China
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Aortic dissection (AD) is a serious and frequently fatal condition with highly variable presentations, which increases the difficulty of diagnosis during the incubation period. The objective of this study was to reveal the influence of gut microbiota and metabolites on the occurrence and development of AD. In the present study, a total of 132 volunteers were recruited, but only 50 met the experimental requirements (including 25 health controls and 25 patients with AD). Patients with AD showed the high levels of systolic blood pressure (SBP) and diastolic blood pressure (DBP), accompanied with aortic dilation. High-throughput sequencing revealed a reduction in the abundance of beneficial bacteria (containing Bifidobacterium and [Eubacterium]_eligens_group) and an increase in harmful bacteria (containing Desulfovibrio and Hungatella) in patients with AD. In addition, untargeted metabolomic identified a total of 304 metabolites that were remarkably changes in AD patients, which major involved in alactose metabolism, caffeine metabolism, tyrosine metabolism, taurine and hypotaurine metabolism, ascorbate and aldarate metabolism, and butanoate metabolism. The above data elucidate that distinct gut microbiota and metabolites in AD patients, offering reliable information to building the prediction models of AD.
Keywords: aortic dissection, phenotype, Gut Microbiota, gut metabolites, metabolic pathway
Received: 01 Aug 2025; Accepted: 24 Sep 2025.
Copyright: © 2025 Liu, Lin, Zhong, Liang, Liu and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yun-nan Hu, huyunnan@fjmu.edu.cn
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