MINI REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1682110
This article is part of the Research TopicImpact of Gut Probiotic Metabolites on Human Metabolic DiseasesView all 12 articles
Impact of gut probiotic metabolites on Phenylketonuria
Provisionally accepted
- Vellore Institute of Technology, Vellore, India
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Phenylketonuria is an unusual inherited metabolic disease induced by mutations of the phenylalanine hydroxylase gene, resulting in phenylalanine accumulation. The current treatments only focus on restricting lifelong dietary intake of phenylalanine, posing a significant challenge to concordance and living standards. Emerging evidence on phenylketonuria disorders underscores the gut microbiome involving probiotics as a key mediator of host metabolic processes. This review encompasses the insights into the pathophysiology of phenylketonuria, gut probiotics, the amino acid metabolism of phenylalanine, the mechanism of action of probiotics, and the therapeutic potential of the treatments available.
Keywords: phenylketonuria, metabolic disorders, human, Gut probiotics, Amino Acids, Phenylalanine, Mechanism, Tyrosine
Received: 08 Aug 2025; Accepted: 22 Sep 2025.
Copyright: © 2025 Kalla Veedu, Vijayakumar, Joseph and Thomas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: John Thomas, john.thomas@vit.ac.in
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