MINI REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Molecular Bacterial Pathogenesis
Survival Strategies of Mycoplasmas: The Critical Role of Post-Translational Modifications
Provisionally accepted
- 1Xiangya Hospital Central South University, Changsha, China
- 2The First People's Hospital of Chenzhou, Chenzhou, China
- 3First Clinical College, University Library, Xiangnan University, Chenzhou, China
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Mycoplasmas are unique prokaryotic pathogens distinguished by their lack of a cell wall. These microorganisms are widespread in nature and can cause severe infections, leading to substantial tissue damage. Recent advances in mycoplasmology, driven by developments in molecular biology and proteomics, have provided novel insights into their pathogenicity and pathogenic mechanisms. However, critical knowledge gaps remain in understanding their biology. Emerging evidence highlights the crucial role of protein post-translational modifications (PTMs) in regulating mycoplasma physiology, including virulence, metabolic adaptation, and persistence. Investigating mycoplasma PTMs in greater depth promises to expand our understanding of their pathogenic strategies and may reveal new targets for therapeutic intervention against mycoplasma-associated diseases.
Keywords: Mycoplasmas, post-translational modifications, Phosphorylation, Acetylation, Glycosylation
Received: 19 Aug 2025; Accepted: 05 Nov 2025.
Copyright: © 2025 Li, Yuan, Zhang and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wenjun Zhang, 1466202734@qq.com
Fangyi Guo, guofy97@163.com
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