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ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.

Sec. Extra-intestinal Microbiome

Gut and Oral Microbiome Profiles in Patients with Obesity and Ischemic Heart Disease

Provisionally accepted
Antonina StarodubovaAntonina Starodubova1,2Georgy LeonovGeorgy Leonov1*Natalya ShaposhnikovaNatalya Shaposhnikova1Yurgita VaraevaYurgita Varaeva1Elena LivantsovaElena Livantsova1Denis FotinDenis Fotin2Tatiana V. KirichenkoTatiana V. Kirichenko3Mariam Bagheri EktaMariam Bagheri Ekta3Yuliya MarkinaYuliya Markina3Stanislav KoshechkinStanislav Koshechkin4Alexander OrekhovAlexander Orekhov5Dmitry NikityukDmitry Nikityuk1
  • 1Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia
  • 2Pirogov Russian National Research Medical University, Moscow, Russia
  • 3Petrovsky National Research Center of Surgery, Moscow, Russia
  • 4Nobias Technologies, Moscow, Russia
  • 5Institute of General Pathology and Pathophysiology, Moscow, Russia

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Background: Ischemic heart disease (IHD) and obesity are major contributors to global mortality. Both conditions are linked to systemic inflammation, dyslipidemia, and microbiota alterations. This study examines the relationship between the composition of the gut and oral microbiota, obesity and IHD to gain insight into the interconnections between these factors. Methods: The study included 182 participants divided into four groups based on obesity and IHD status. Anthropometric and biochemical analyses were performed. Oral and gut microbiomes were analyzed using 16S rRNA sequencing. Results: Obesity and IHD were associated with distinct microbiota compositions. Obesity-IHD subjects showed elevated levels of gut Streptococcus, Intestinibacter, alongside reduced Citrobacter, Ruthenibacterium, Parabacteroides, and Flavonifractor. The oral microbiota exhibited decreased Alloprevotella, Capnocytophaga, Prevotellamassilia, and Campylobacter in Obesity-IHD. Correlation analysis highlighted associations between microbial taxa (e.g., Blautia, Oscillibacter) and clinical parameters like BMI, blood pressure, and cholesterol. Conclusions: This study demonstrates that obesity and IHD are linked to unique microbiota alterations. Microbial dysbiosis may contribute to the pathogenesis of these conditions and should be considered as a therapeutic target in the development of personalized treatment strategies of the obesity and associated cardiovascular complications.

Keywords: gut microbiome1, oral microbiome2, 16S rRNA sequencing3, Obesity4, IHD5

Received: 01 Sep 2025; Accepted: 03 Nov 2025.

Copyright: © 2025 Starodubova, Leonov, Shaposhnikova, Varaeva, Livantsova, Fotin, Kirichenko, Bagheri Ekta, Markina, Koshechkin, Orekhov and Nikityuk. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Georgy Leonov, golerus@gmail.com

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material