REVIEW article
Front. Cell. Infect. Microbiol.
Sec. Adaptive & Innate Immunity in Infection
This article is part of the Research TopicTargeting Non-Coding RNAs in Viral Disease Management: Potential as Therapeutic Targets and Diagnostic BiomarkersView all articles
The Role of Long Non-coding RNAs and Circular RNAs in Immune Evasion of Influenza A Virus: Recent Advances
Provisionally accepted
- Department of Pediatric Respiration, Children’s Medical Center, The First Hospital of Jilin University, Changchun, China
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The capacity of influenza A virus (IAV) to circumvent immune defenses in hosts renders it a persistent major peril to worldwide public health. Investigations conducted lately underscore the vital functions played by circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) during interactions between viruses and their hosts. This review summarizes current understanding of how lncRNAs and circRNAs participate in IAV immune evasion by regulating antiviral signaling pathways, interfering with interferon responses, modulating inflammatory cytokine production and cell metabolism, and affecting viral replication. This review examines molecular actions exhibited by particular lncRNAs and circRNAs within such interactions, assesses their suitability for therapeutic targets and diagnostic biomarkers, and outlines avenues for subsequent investigations across this fast-developing domain.
Keywords: long non-coding RNA, circular RNA, Influenza A virus, Immune Evasion, antiviral response
Received: 19 Sep 2025; Accepted: 06 Nov 2025.
Copyright: © 2025 Yanghua, Yanchun, Chenxu and Xiuhua. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu Xiuhua, yuxiuhua@jlu.edu.cn
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