ORIGINAL RESEARCH article
Front. Cell. Infect. Microbiol.
Sec. Intestinal Microbiome
This article is part of the Research TopicImpact of Gut Probiotic Metabolites on Human Metabolic DiseasesView all 16 articles
Comprehensive nursing care for Advanced digestive malignancy patients during chemotherapy based on probiotic intervention: a randomized controlled study on improvement of gastrointestinal function and prevention of complications
Provisionally accepted
- Clinical Oncology School of Fujian Medical University, Fuzhou, China
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Objective: This study aims to investigate the effects of a comprehensive nursing protocol combined with a probiotic intervention on improving gastrointestinal function, reducing non-infectious complications, and enhancing the quality of life in patients with advanced digestive malignancies undergoing chemotherapy, thereby providing evidence-based support for chemotherapy nursing care. Methods: A total of 300 advanced digestive malignancy patients undergoing chemotherapy at Our Oncology Specialty Hospital from January 2021 to December 2024 were randomly divided into a control group (150 patients) and an observation group (150 patients) using a random number table. The control group received conventional chemotherapy nursing care, while the observation group received a combined probiotic intervention along with comprehensive nursing care. Baseline data, gastrointestinal function scores (bloating, diarrhea, constipation, nausea/vomiting), nutritional status indicators (serum albumin, prealbumin, BMI), and quality of life scores (EORTC QOLQ-C30) were recorded before and after 2, 4, and 8 weeks of intervention. Non-infectious complications and nursing satisfaction were also evaluated. The dynamic effects of the intervention were analyzed using Generalized Estimation Equations (GEE). Results: No significant differences were observed between the groups at baseline (P>0.05). However, after 2, 4, and 8 weeks of intervention, the observation group exhibited significantly improved gastrointestinal function, with lower scores across all dimensions compared to the control group (P<0.05). At week 8, the total gastrointestinal function score in the observation group (1.57±0.58) was significantly lower than the control group (3.74±1.05) (t=22.156, P=0.000). The observation group also showed significantly higher nutritional indicators: serum albumin (41.53±2.96 vs. 36.18±3.42), prealbumin (276.41±17.53 vs. 218.65±20.37), and BMI (23.58±2.86 vs. 22.37±3.21) (P<0.01). Additionally, the observation group had higher quality of life scores and lower complication rates (P<0.05), with increased nursing satisfaction. GEE analysis confirmed that the observation group showed greater improvements in all measured indicators over time compared to the control group (P<0.01). Conclusion: The comprehensive nursing protocol with probiotic intervention significantly improves gastrointestinal function, enhances nutritional status, reduces non-infectious complications, and boosts the quality of life in chemotherapy patients with advanced digestive malignancy. This intervention demonstrates substantial clinical benefits and therapeutic value.
Keywords: Probiotics, Advanced digestive malignancy patients, chemotherapy, comprehensivenursing, gastrointestinal function, complications
Received: 04 Oct 2025; Accepted: 18 Nov 2025.
Copyright: © 2025 Huang, Zhuo, Zhang, Gao, He and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lanlan Zhang, lanlanzhang595@gmail.com
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