Frontiers in Cellular Neuroscience | Cellular Neuropathology

Original Research

Published on 23 Jan 2026

Differential microglial dynamics and neuroinflammation underlying neuropathic pain in the central nervous system: comparative insights from spinal cord injury and compressive myelopathy models

in Cellular Neuropathology

Arisa Kubota
Hideaki Nakajima
Kazuya Honjoh
Shuji Watanabe
Ai Takahashi
Akihiko Matsumine

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2026.1769004

490 views

Review

Published on 22 Jan 2026

Extracellular vesicles in Niemann pick disease type C: current knowledge and future opportunities

in Cellular Neuropathology

Sarah Catherine B. Hawthorne
Ursula S. Sandau
Julie A. Saugstad

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1730603

584 views

Original Research

Published on 21 Jan 2026

Glutamate load fosters spreading depolarization under osmotic stress in brain slices

in Cellular Neuropathology

Rita Frank
Stephane Marinesco
Ferenc Bari
Ákos Menyhárt
Eszter Farkas

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1722194

765 views

Review

Accepted on 20 Jan 2026

Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies.

in Cellular Neuropathology

Georgie Lines
Martin Helley
Sébastien Gillotin
Janet Brownlees
James Duce
Phillip Smethurst

Frontiers in Cellular Neuroscience

151 views

Original Research

Published on 20 Jan 2026

Intermittent fasting reduces glaucomatous damage in an HSP27 autoimmune mouse model

in Cellular Neuropathology

Dominik L. Maler
Sabrina Reinehr
Leonie Deppe
H. Burkhard Dick
Stephanie C. Joachim

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1690991

770 views

Review

Accepted on 19 Jan 2026

Inflammatory Mechanisms Underlying Early Alzheimer's Disease Pathology: Evidence from the Aging Rhesus Macaque Brain

in Cellular Neuropathology

Dibyadeep Datta
Min Wang
Amy F T Arnsten

Frontiers in Cellular Neuroscience

123 views

Original Research

Accepted on 15 Jan 2026

C9orf72-ALS mutation drives basal mitophagy impairments in iNeurons

in Cellular Neuropathology

James A. K. Lee
Chloe Moutin
Allan C. Shaw
Sarah Granger
Katie Roome
Scott Allen
Laura Ferraiuolo
Pamela Jean Shaw
Heather Jane Mortiboys

Frontiers in Cellular Neuroscience

354 views

Specialty Grand Challenge

Published on 06 Jan 2026

Hot topics in Cellular Neuropathology IV—targeting neurological diseases by gene therapy approaches

in Cellular Neuropathology

Dirk M. Hermann

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1769815

1,147 views

Original Research

Accepted on 05 Jan 2026

Increased dendritic inhibition of dentate gyrus granule cells in a mouse model of Down syndrome

in Cellular Neuropathology

Nicole Gutmann
Ute Häussler
Anabel Mersi
Marie Follo
Josef Bischofberger
Jan M Schulz

Frontiers in Cellular Neuroscience

318 views

Original Research

Published on 02 Jan 2026

Trazodone modulates behavioral alterations in scopolamine-induced cognitive deficit by targeting brain-derived neurotropic factor and cAMP response element-binding protein signaling

in Cellular Neuropathology

Prashant Dhaka
Pinky
Neha
Mohammad Ahmad Khan
Syed Arman Rabbani
Mohamed El-Tanani
Suhel Parvez

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1681080

1,069 views

Review

Accepted on 29 Dec 2025

Molecular and developmental insights into proprioceptive identity in the mesencephalic trigeminal nucleus neurons

in Cellular Neuropathology

Pa Reum Lee
Seog Bae Oh

Frontiers in Cellular Neuroscience

547 views

Original Research

Accepted on 22 Dec 2025

Neuronal differentiation and activity drive nucleocytoplasmic shuttling of the intellectual disability kinase TLK2

in Cellular Neuropathology

Lubna Nuhu-Soso
Heidi Denton
Darren L Goffin
Ines Hahn
Gareth J.O. Evans

Frontiers in Cellular Neuroscience

284 views

Review

Published on 17 Dec 2025

Neural stem cells fate under neuroinflammatory conditions and oxidative stress response

in Cellular Neuropathology

Filippo Torrisi
Simona Denaro
Jenny Ragonese
Simona D’Aprile
Agata Zappalà
Rosalba Parenti

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1736865

1,223 views

Original Research

Published on 17 Dec 2025

Neurosteroid withdrawal disrupts GABAergic system development in human cortical organoids: implications for preterm birth

in Cellular Neuropathology

Helene Lacaille
Ekaterina Lebayle
Barbara Corneo
Claire-Marie Vacher
Anna A. Penn

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1715823

1,534 views

Brief Research Report

Published on 15 Dec 2025

Single-nucleus RNA-seq reveals no increase in T cells in Alzheimer’s disease prefrontal cortex or hippocampus

in Cellular Neuropathology

Jake D. Oxendine
Daniel W. Sirkis
Caroline Jonson
Jennifer S. Yokoyama

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1681881

1,639 views

Original Research

Published on 15 Dec 2025

Study on the effect of mesenchymal stem cells on neural injury, inflammation and copper content in Wilson disease

in Cellular Neuropathology

Xiang-xue Zhou
Hao-ling Qin
Dingbang Chen
Jian Liao
Yinjie Liu

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1648155

1,126 views

Review

Published on 08 Dec 2025

Astrocytic and microglial cell functions in neuroinflammatory diseases and their animal models

in Cellular Neuropathology

Kei Hashimoto
Mari Gotoh
Hiroko Ikeshima-Kataoka

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1708775

1,927 views

Original Research

Published on 05 Dec 2025

Long-term low-dose aspirin promotes laser-induced choroidal neovascularization through suppressing TSP-1 expression

in Cellular Neuropathology

Caijiao Yi
Chang Luo
Jiawu Zhao
Christophe Roubeix
Judith Lechner
Rosana Penalva
Nan Yang
Jian Liu
Qichang Wang
Usha Chakravarthy

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1716229

1,471 views

Review

Published on 03 Dec 2025

Deciphering the role of tRNA-derived fragments in neurological and psychiatric disease pathogenesis

in Cellular Neuropathology

Huseyin Kocakusak
Aysu Başak Kök
Bilgesu Ozturk
Bilge Karacicek
Sermin Genc

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1663788

2,037 views
1 citation

Perspective

Published on 25 Nov 2025

Fetal development and the air pollution exposome: an integrative perspective of health pathways

in Cellular Neuropathology

Eric Alonso Abarca-Castro
José Javier Reyes-Lagos
Kioko Guzmán Ramos
Augusto J. Montiel-Castro
Hypatia Arano-Varela
Pablo Adolfo Mayer-Villa
José Eleazar Aguilar-Toalá
José Luis Montesillo-Cedillo
Ana Karen Talavera-Peña

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1688437

1,932 views
2 citations

Correction

Published on 24 Nov 2025

Correction: CRISPR-Cas9: bridging the gap between aging mechanisms and therapeutic advances in neurodegenerative disorders

in Cellular Neuropathology

Anas Shamsi
Mohammed Alrouji
Othman AlOmeir
Syed Tasqeruddin
Khuzin Dinislam
Azna Zuberi

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1739705

1,303 views

Mini Review

Published on 21 Nov 2025

Persistent pollutants and the developing brain: the role of PFAS in neurodevelopmental disorders

in Cellular Neuropathology

Laura Lagostena
Valeria Magnelli
Davide Rotondo
Francesco Dondero

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1696173

2,875 views

Correction

Published on 20 Nov 2025

Correction: The role of oxidative stress in spinal cord ischemia reperfusion injury: mechanisms and therapeutic implications

in Cellular Neuropathology

Yu Xing
Yuan-zhang Xiao
Min Zhao
Jiang-jun Zhou
Kai Zhao
Chun-lin Xiao

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1742278

767 views

Review

Published on 10 Nov 2025

Microglia-orchestrated neuroinflammation and synaptic remodeling: roles of pro-inflammatory cytokines and receptors in neurodegeneration

in Cellular Neuropathology

Guang Yang
Xiao Xu
Waimao Gao
Xingyu Wang
Yan Zhao
Ying Xu

Frontiers in Cellular Neuroscience

doi 10.3389/fncel.2025.1700692

3,379 views
9 citations

2,079 articles

articles

Differential microglial dynamics and neuroinflammation underlying neuropathic pain in the central nervous system: comparative insights from spinal cord injury and compressive myelopathy models

Extracellular vesicles in Niemann pick disease type C: current knowledge and future opportunities

Glutamate load fosters spreading depolarization under osmotic stress in brain slices

Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies.

Intermittent fasting reduces glaucomatous damage in an HSP27 autoimmune mouse model

Inflammatory Mechanisms Underlying Early Alzheimer's Disease Pathology: Evidence from the Aging Rhesus Macaque Brain

C9orf72-ALS mutation drives basal mitophagy impairments in iNeurons

Hot topics in Cellular Neuropathology IV—targeting neurological diseases by gene therapy approaches

Increased dendritic inhibition of dentate gyrus granule cells in a mouse model of Down syndrome

Trazodone modulates behavioral alterations in scopolamine-induced cognitive deficit by targeting brain-derived neurotropic factor and cAMP response element-binding protein signaling

Molecular and developmental insights into proprioceptive identity in the mesencephalic trigeminal nucleus neurons

Neuronal differentiation and activity drive nucleocytoplasmic shuttling of the intellectual disability kinase TLK2

Neural stem cells fate under neuroinflammatory conditions and oxidative stress response

Neurosteroid withdrawal disrupts GABAergic system development in human cortical organoids: implications for preterm birth

Single-nucleus RNA-seq reveals no increase in T cells in Alzheimer’s disease prefrontal cortex or hippocampus

Study on the effect of mesenchymal stem cells on neural injury, inflammation and copper content in Wilson disease

Astrocytic and microglial cell functions in neuroinflammatory diseases and their animal models

Long-term low-dose aspirin promotes laser-induced choroidal neovascularization through suppressing TSP-1 expression

Deciphering the role of tRNA-derived fragments in neurological and psychiatric disease pathogenesis

Fetal development and the air pollution exposome: an integrative perspective of health pathways

Correction: CRISPR-Cas9: bridging the gap between aging mechanisms and therapeutic advances in neurodegenerative disorders

Persistent pollutants and the developing brain: the role of PFAS in neurodevelopmental disorders

Correction: The role of oxidative stress in spinal cord ischemia reperfusion injury: mechanisms and therapeutic implications

Microglia-orchestrated neuroinflammation and synaptic remodeling: roles of pro-inflammatory cytokines and receptors in neurodegeneration