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Original Research

Published on 23 Apr 2025

Structural and dynamical characterization of pRb, LTSV40 and the pRb-LTSV40 complex suggests a common mechanism for pRb inactivation

in Theoretical Modeling, Structure Prediction & Design

Carla Luciana Padilla Franzotti
Nicolas Palopoli
Juliana Palma
Gustavo Pierdominici-Sottile

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1538350

241 views

Original Research

Accepted on 18 Apr 2025

Exploring the heterodimer MDM2/MDM4 interaction region uncovers high-affinity peptides for therapeutic p53-reactivation

in Theoretical Modeling, Structure Prediction & Design

Marika Attili
Sonia Valentini
Maria Pesavento
Marco Ballarotto
Viviana Scognamiglio
Alfredo Pontecorvi
Antonio Macchiarulo
Fulvio Saccoccia
Fabiola Moretti

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1576640

101 views

Original Research

Published on 06 Jan 2025

Exploring the NANOG-TET2 interaction interface. Effects of a selected mutation and hypothesis on the clinical correlation with anemias

in Theoretical Modeling, Structure Prediction & Design

Claudia Testi
Roberta Piacentini
Alessandro Perrone
Chiara Bartoli
Daniele Leso
Domitilla Pavia
Elisa Pistolesi
Flavio Scipione
Irene Cotronea
Marco Adinolfi Falcone

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1517163

771 views

Original Research

Published on 23 Jul 2024

In silico enzyme screening identifies an SDR ketoreductase from Thermus caliditerrae as an attractive biocatalyst and promising candidate for protein engineering

in Theoretical Modeling, Structure Prediction & Design

Yvett Sosa
Bhav Kapur
Jessica Hurtak
Laura J. Kingsley
Hao Wu
Stefanie Gruber
Herbert Nar
Saad Khattabi
Jesus Seco Moral
Maria Fátima Lucas

Frontiers in Chemical Biology

doi 10.3389/fchbi.2024.1425501

2,196 views