Frontiers in Drug Discovery

Perspective

Published on 19 Feb 2025

Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

in Technologies and Strategies to Enable Drug Discovery

K. Taylor
R. Ram
L. Ewart
C. Goldring
G. Russomanno
G. P. Aithal
T. Kostrzewski
C. Bauch
J. M. Wilkinson
S. Modi

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1536756

5,801 views
5 citations

Review

Published on 29 Jan 2025

Non-enzymatic protein targeting agents as a promising strategy for cancer treatment

in Anti-Cancer Drugs

Madison Ambrose
Jeremy Lee
Aleem Syed
Zamal Ahmed
Guang Peng

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1520734

6,142 views

Original Research

Published on 03 Jan 2025

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

in Technologies and Strategies to Enable Drug Discovery

Stefanie Hoffmann
Philip Hewitt
Isabel Koscielski
Dorota Kurek
Wouter Strijker
Kinga Kosim

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459424

4,805 views
3 citations

Review

Published on 19 Dec 2024

Targeting steroid receptor coactivators in cancer via small molecule agents

in Anti-Cancer Drugs

Yosi Gilad
Ortal Shimon
David M. Lonard
Bert W. O’Malley

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1514412

2,214 views
2 citations

Editorial

Published on 29 Nov 2024

Editorial: Drug discovery and development explained: introductory notes for the general public

in Technologies and Strategies to Enable Drug Discovery

Bruno O. Villoutreix
Jean-Luc Poyet
Katya Tsaioun

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1528467

2,825 views

Review

Published on 19 Nov 2024

Decoding lung complexity: single-cell sequencing in lung diseases, regeneration, and drug discovery

in Technologies and Strategies to Enable Drug Discovery

Peng Wang
Nan Tang

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1495208

3,287 views
1 citation

Original Research

Published on 29 Oct 2024

Drug–drug interaction extraction based on multimodal feature fusion by Transformer and BiGRU

in In silico Methods and Artificial Intelligence for Drug Discovery

Changqing Yu
Shanwen Zhang
Xuqi Wang
Tailong Shi
Chen Jiang
Sizhe Liang
Guanghao Ma

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1460672

2,463 views
1 citation

Review

Published on 22 Oct 2024

Single-cell multiomics: a new frontier in drug research and development

in Technologies and Strategies to Enable Drug Discovery

Jiaxiu Ma
Chao Dong
Aibin He
Haiqing Xiong

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1474331

5,121 views
1 citation

Review

Published on 18 Oct 2024

Single-cell technology for drug discovery and development

in Technologies and Strategies to Enable Drug Discovery

Anzhuo Zhang
Jiawei Zou
Yue Xi
Lianchong Gao
Fulan Deng
Yujun Liu
Pengfei Gao
Henry H. Y. Tong
Lianjiang Tan
Xin Zou

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459962

8,366 views
6 citations

Review

Published on 16 Oct 2024

Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders

in Anti-Infective Agents

Lucia Falcigno
Simone Braccia
Rosa Bellavita
Gabriella D’Auria
Annarita Falanga
Stefania Galdiero

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1440378

4,648 views
8 citations

Brief Research Report

Published on 07 Oct 2024

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

in Technologies and Strategies to Enable Drug Discovery

Liam M. Ashander
Amanda L. Lumsden
Yuefang Ma
Alwin Chun Rong Tan
Binoy Appukuttan
Santhosh Daniel
Michael Z. Michael
Justine R. Smith

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1416728

1,536 views
1 citation

Original Research

Published on 02 Oct 2024

Artificial intelligence driven image analysis identifies phenobarbital induced hepatocyte hypertrophy in liver microtissues across species

in Technologies and Strategies to Enable Drug Discovery

Matthew Elcombe
Ayesha Mathur
Stephanie Wallace
Jayne Wright
Simon Plummer

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1472522

2,711 views
1 citation

Mini Review

Published on 02 Oct 2024

The role of the HIV-1 gut reservoir in driving early cardiovascular events in people living with HIV

in Anti-inflammatory and Immunomodulating Agents

Keri Kramer
Amanda Michael
Guadalupe Quiñones
Sebastian Roa
Susan P. Ribeiro
Cecile D. Lahiri
Christina Gavegnano

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1334307

1,915 views

Review

Published on 30 Sep 2024

Combating cancer stem cells: RNA m6A methylation and small-molecule drug discovery

in Anti-Cancer Drugs

Honghai Zhang
Xueer Wang
Jianjun Chen
Rui Su

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1465222

3,424 views
4 citations

Original Research

Published on 13 Sep 2024

The chronicles of inflammation: uncovering of distinct patterns of NET degradation products

in Anti-inflammatory and Immunomodulating Agents

Janina Schoen
Marco Muñoz-Becerra
Jasmin Knopf
Favour Ndukwe
Moritz Leppkes
Dominik Roth
Anne Zeitler
Verena Gerlinde Frings
Bettina Hohberger
Victoria Zeisberg

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1404103

2,077 views

Review

Published on 06 Sep 2024

Cathelicidins—a rich seam of antimicrobial peptides waiting for exploitation

in Anti-Infective Agents

Alessandro Tossi
Marco Gerdol
Andrea Caporale
Sabrina Pacor
Mario Mardirossian
Marco Scocchi
Michael D. Prickett
Giorgio Manzini
Renato Gennaro

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1458057

5,827 views
7 citations

Mini Review

Published on 03 Sep 2024

AI-accelerated therapeutic antibody development: practical insights

in In silico Methods and Artificial Intelligence for Drug Discovery

Luca Santuari
Marianne Bachmann Salvy
Ioannis Xenarios
Bulak Arpat

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1447867

9,248 views
9 citations

Mini Review

Published on 20 Aug 2024

How drug repurposing can advance drug discovery: challenges and opportunities

in In silico Methods and Artificial Intelligence for Drug Discovery

Luca Pinzi
Nicolò Bisi
Giulio Rastelli

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1460100

18,265 views
50 citations

Hypothesis and Theory

Published on 15 Aug 2024

Multiparameter ranking of carbazoles for anti-trypanosome lead discovery

in Technologies and Strategies to Enable Drug Discovery

Amrita Sharma
Carlos E. Sanz-Rodriguez
Michael P. Pollastri
Andrei Purmal
Kojo Mensa-Wilmot

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1430927

2,092 views

Original Research

Published on 26 Jul 2024

Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model

in Technologies and Strategies to Enable Drug Discovery

Melanie Grotz
Lieke van Gijzel
Peter Bitsch
Stefania C. Carrara
Harald Kolmar
Sakshi Garg

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1427407

4,658 views
2 citations

Methods

Published on 22 Jul 2024

An anesthetized rat assay for evaluating the effects of organophosphate-based compounds and countermeasures on intracranial EEG and respiratory rate

in Technologies and Strategies to Enable Drug Discovery

J. S. Thinschmidt
S. W. Harden
J. D. Talton
C. J. Frazier

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1393964

1,887 views

Review

Published on 17 Jul 2024

Alternative therapeutics to control antimicrobial resistance: a general perspective

in Anti-Infective Agents

Biplab Singha
Vinayak Singh
Vijay Soni

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1385460

18,804 views
46 citations

Mini Review

Published on 09 Jul 2024

The role of physicochemical and topological parameters in drug design

in In silico Methods and Artificial Intelligence for Drug Discovery

Janki Darlami
Shweta Sharma

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1424402

6,944 views
8 citations

Editorial

Published on 15 May 2024

Editorial: Recent trends in anti-cancer drug discovery by in silico methods

in In silico Methods and Artificial Intelligence for Drug Discovery

Carmen Cerchia
Jose Correa Basurto
Angelo Lupo
Antonio Lavecchia

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1420267

2,221 views

155 articles

articles

Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

Non-enzymatic protein targeting agents as a promising strategy for cancer treatment

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

Targeting steroid receptor coactivators in cancer via small molecule agents

Editorial: Drug discovery and development explained: introductory notes for the general public

Decoding lung complexity: single-cell sequencing in lung diseases, regeneration, and drug discovery

Drug–drug interaction extraction based on multimodal feature fusion by Transformer and BiGRU

Single-cell multiomics: a new frontier in drug research and development

Single-cell technology for drug discovery and development

Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders

Brief research report: Transcriptional blockade of angiotensin converting enzyme 2 modelled in human retinal pigment epithelial cells

Artificial intelligence driven image analysis identifies phenobarbital induced hepatocyte hypertrophy in liver microtissues across species

The role of the HIV-1 gut reservoir in driving early cardiovascular events in people living with HIV

Combating cancer stem cells: RNA m6A methylation and small-molecule drug discovery

The chronicles of inflammation: uncovering of distinct patterns of NET degradation products

Cathelicidins—a rich seam of antimicrobial peptides waiting for exploitation

AI-accelerated therapeutic antibody development: practical insights

How drug repurposing can advance drug discovery: challenges and opportunities

Multiparameter ranking of carbazoles for anti-trypanosome lead discovery

Mimicking the immunosuppressive impact of fibroblasts in a 3D multicellular spheroid model

An anesthetized rat assay for evaluating the effects of organophosphate-based compounds and countermeasures on intracranial EEG and respiratory rate

Alternative therapeutics to control antimicrobial resistance: a general perspective

The role of physicochemical and topological parameters in drug design

Editorial: Recent trends in anti-cancer drug discovery by in silico methods