ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Systems Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1530067
Association between metabolic score for insulin resistance and lower limb pain among the elderly: a cross-sectional study
Provisionally accepted
- 1The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- 2Jianjiyue Biomedical Research Center, Xi’an, China
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Insulin resistance holds a central position in the complex process of aging. Previous studies have indicated that insulin resistance is linked not only to diabetes but also to multiple cardiovascular diseases. Few studies investigated the relationship between the metabolic score of insulin resistance (Mets-IR) and lower limb pain (LLP) in geriatric endocrinology.Our research in this paper reveals a significant connection between Mets-IR and LLP. The risk of LLP escalates with an increase in the Mets-IR index. Furthermore, this relationship is influenced by variations in sleep duration. Our findings may pave the way for novel approaches in the prevention and management of LLP in older adults. This underscores the potential of insulin resistance as a pivotal factor in multi-system disorders.
Keywords: Lower Limb Pain, Insulin Resistance, metabolic syndrome, Metabolic score for insulin resistance, Cross-sectional study
Received: 22 Nov 2024; Accepted: 06 Jun 2025.
Copyright: © 2025 Hu, Yu, Xu, Gao, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yanfen Hu, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Lingxia Li, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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