Your new experience awaits. Try the new design now and help us make it even better

ORIGINAL RESEARCH article

Front. Endocrinol.

Sec. Systems Endocrinology

Volume 16 - 2025 | doi: 10.3389/fendo.2025.1530067

Association between metabolic score for insulin resistance and lower limb pain among the elderly: a cross-sectional study

Provisionally accepted
Yanfen  HuYanfen Hu1*Junxia  YuJunxia Yu1Zhenjie  XuZhenjie Xu2Yan  GaoYan Gao2Yang  LiYang Li1Lingxia  LiLingxia Li1*
  • 1The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
  • 2Jianjiyue Biomedical Research Center, Xi’an, China

The final, formatted version of the article will be published soon.

Insulin resistance holds a central position in the complex process of aging. Previous studies have indicated that insulin resistance is linked not only to diabetes but also to multiple cardiovascular diseases. Few studies investigated the relationship between the metabolic score of insulin resistance (Mets-IR) and lower limb pain (LLP) in geriatric endocrinology.Our research in this paper reveals a significant connection between Mets-IR and LLP. The risk of LLP escalates with an increase in the Mets-IR index. Furthermore, this relationship is influenced by variations in sleep duration. Our findings may pave the way for novel approaches in the prevention and management of LLP in older adults. This underscores the potential of insulin resistance as a pivotal factor in multi-system disorders.

Keywords: Lower Limb Pain, Insulin Resistance, metabolic syndrome, Metabolic score for insulin resistance, Cross-sectional study

Received: 22 Nov 2024; Accepted: 06 Jun 2025.

Copyright: © 2025 Hu, Yu, Xu, Gao, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Yanfen Hu, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Lingxia Li, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.