REVIEW article
Front. Endocrinol.
Sec. Diabetes: Molecular Mechanisms
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1537769
Notch Signaling in Diabetic Kidney Disease: Recent Progress
Provisionally accepted
- 1People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350000, China, Fuzhou, China
- 2Department of Dermatology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
- 3The Affiliated Chinese Medicine Hospital of Chongqing Three Gorges Medical College, Wanzhou, China
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Diabetic kidney disease (DKD) is one of the most serious complications of diabetes mellitus (DM) and the main cause of end-stage renal disease (ESRD). The number of affected patients is increasing annually worldwide. Therefore, it is necessary to establish new strategies to treat DKD and improve prognosis. The Notch signaling pathway is involved in multiple mechanisms in DKD, including glomerular endothelial dysfunction, filtration barrier damage, podocyte EMT and dedifferentiation, tubulointerstitial fibrosis, PT cell dedifferentiation, macrophage polarization, etc. In addition, Notch signaling interacts with other pathways involved in DKD progression, such as TGF-β, Wnt/β-catenin, mTOR, AMPK, autophagy, etc. Therefore, new ideas for the future treatment of DKD may be provided through clarification of the role of the Notch signaling pathway and development of novel drugs.
Keywords: Notch signaling, Diabetic kidney disease, renal fibrosis, podocyte, therapy
Received: 01 Dec 2024; Accepted: 18 Jul 2025.
Copyright: © 2025 Wang, Tu, Long, He and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Tu, Department of Dermatology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
Jing Wu, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350000, China, Fuzhou, China
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