The Role of Adipose tissue in Puberty and Reproductive Health

Xin Ning¹Qing Huang²Doudou Guo¹Yanfen Zhou¹Yating Li¹Xin Li^1*

• ¹Department of Pediatrics, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
• ²International Medical College of Chongqing Medical University, Yuzhong, Chongqing, China

Adipose tissue is an endocrine organ that signals energy status to hypothalamic-pituitary-gonad axis to regulate reproductive function. Notably, in mammals, adipose tissue biology-adipose tissue expansion and body fat distribution-is closely linked to the onset of puberty. Some studies showed that early adipose tissue development tracks into childhood or adulthood, indicating its potential impact on reproductive function. Factors such as maternal obesity, childhood body mass index gain and adolescent obesity significantly contribute to early puberty onset and negative reproductive events including menstrual irregularity, polycystic ovary syndrome and male infertility. However, the connection between adipose tissue development before adulthood (prenatal stage and childhood) and reproductive function has not yet been fully investigated and reviewed. In this study, we present a comprehensive review of hormonal and inherent dimorphisms on adipose tissue development; there is a novel discussion about the link between adipose tissue expansion tracking throughout early life stages and reproductive disorders. Our study aims to elucidate how adipocyte development during critical periods of life can affect future reproductive health from sexual maturation to fertility, and points to the clinical significance of further unlocking the underlying mechanism and weight management. As such, early prevention and long-term management for weight control might be considered as effective measures to mitigate obesity-induced reproductive comorbidities.