Endocrine disorders such as diabetes, metabolic syndrome, and thyroid dysfunctions have been associated with an increased risk for various dental diseases. However, many aspects of these relationships remain to be elucidated. This Research Topic aimed to provide new insights into the connections between endocrine disorders and dental pathologies.
Yang et al.’s study conducted a comprehensive cross-sectional study involving 2,530 euthyroid adults, revealing that reduced sensitivity to thyroid hormones (THs) is associated with a heightened risk of periodontitis. Their findings identify serum 25-hydroxyvitamin D (25[OH]D) as a mediator in this relationship, suggesting that maintaining adequate levels of 25(OH)D may help modulate thyroid hormone sensitivity and subsequently reduce the risk of periodontitis. This mediation likely operates through 25(OH)D’s role in modulating inflammatory pathways and supporting thyroid hormone homeostasis. These insights call for further research to establish causality and explore the therapeutic potential of vitamin D optimization in improving thyroid hormone function and periodontal health.
Furthermore, the study by Yan et al. illuminates the complex interactions between progesterone supplementation and periodontal health in perimenopausal women. Specifically, the research focused on oral administration of 10 mg dihydroxyprogesterone tablets taken twice daily for 10 days per month over a 6-month period. This targeted progesterone intervention demonstrated a context-dependent inflammatory response: enhancing periodontal inflammation in the absence of scaling and root planing (SRP), yet dampening inflammatory markers when combined with SRP. The findings underscore the nuanced role of hormone supplementation in managing periodontal conditions during the perimenopausal transition.”
Additionally, debris from extracted teeth without active pathology showed promise as bone graft expanders supporting regeneration, while promoting gingival healing and tissue integration (Xu et al.). The study specifically used premolars extracted for orthodontic reasons from patients with healthy periodontal tissues and no systemic diseases. Further optimization warrants exploring whether inherent signals may be leveraged to improve outcomes.
Finally, poor oral health marked by periodontitis and tooth loss associated with increased osteoporotic fractures, whereas routine dental care and hygiene linked to reduced fracture hazards (Park et al.). This reinforces the necessity of coordinated management across dental and skeletal health to mitigate systemic bone complications.
Collectively, these findings significantly expanded the current understanding on the relationship between endocrine disorders and dental diseases. Ongoing efforts to translate these findings into coordinated screening and early preventive interventions across medicine and dentistry are critical to alleviate long-term oral-systemic morbidities. Continued mechanistic exploration of connections between endocrine derangements and compromised dental health remains imperative.
Statements
Author contributions
CZ: Writing – original draft, Writing – review & editing. SJ: Writing – review & editing. NZ: Writing – review & editing. YL: Writing – original draft, Writing – review & editing.
Funding
The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Natural Science Foundation of Fujian Province (2023J05131). Youth Scientific Research Project of Fujian Provincial Health Commission (2022QNA038). Joint Funds for the Innovation of Science and Technology, Fujian Province (2023Y9061). Talent Introduction Scientific Research Project of the First Affiliated Hospital of Fujian Medical University (2022-YJRC3914). The First Affiliated Hospital of Fujian Medical University Excellent Talent Program (YXRQN-ZCF2023).
Acknowledgments
We sincerely express our gratitude towards all the submitting authors for contributing to this Research Topic, the chief editor and the reviewers for their effort and time to enhance the quality of the manuscripts.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
endocrine disorders, dental diseases, bone remodelling, adipokine, endocrine factors
Citation
Zhang C, Jiang S, Zheng N and Lin Y (2025) Editorial: New insights into the relationship between endocrine disorders and dental diseases. Front. Endocrinol. 16:1560318. doi: 10.3389/fendo.2025.1560318
Received
14 January 2025
Accepted
30 January 2025
Published
11 February 2025
Volume
16 - 2025
Edited and reviewed by
Alberto Falchetti, Niguarda Ca’ Granda Hospital, Italy
Updates
Copyright
© 2025 Zhang, Jiang, Zheng and Lin.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yunzhi Lin, linda_dentist@fjmu.edu.cn
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.