REVIEW article
Front. Endocrinol.
Sec. Gut Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1562332
This article is part of the Research TopicInteractions between tissues and kingdoms and interplay with environmental factors: impact on metabolic health and diseasesView all 4 articles
Gut microbiota has the potential to improve health of menopausal women by regulating estrogen
Provisionally accepted
- Heilongjiang Uniersity of Chinese Medicine, HERBIN, China
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Menopause is an age-related loss of ovarian function. As a woman enters menopause, the estrogen produced by her ovaries decreases, which will adversely affect women's health. The symptoms related to menopause are related to the imbalance of gut microbiota. Studies have shown that the diversity of gut microbiota after menopause is lower than that before menopause, and the weakening of microbial decomposition will lead to the decrease of circulating estrogen, gradually resulting in disorders of lipid metabolism, cognitive decline, osteoporosis and other diseases. Gut microbiota play a key role in regulating estrogen levels. By secreting β-glucuronidase, it increases the reabsorption of estrogen in the enterohepatic circulation and mediates phytoestrogen metabolism, regulates estrogen homeostasis in the host and affects disease development and prognosis. Therefore, the gut microbiota is an overall regulator of women's estrogen status during menopause and an untapped new area for improving women's postmenopausal health. Changing the gut microbiota through specific prebiotics, probiotics, etc., and then affecting estrogen levels provides exciting opportunities for future therapeutic applications.
Keywords: Gut Microbiota, Menopause, estrogen, Lipid metabolism disorder, Cognition impairment, clinical application
Received: 17 Jan 2025; Accepted: 19 May 2025.
Copyright: © 2025 Wang, Shi, Zheng, Zhou, Mi, Wu and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: ling Xiao Feng, Heilongjiang Uniersity of Chinese Medicine, HERBIN, China
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