ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Systems Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1562837
This article is part of the Research TopicTargeting Adipose Tissue for the Treatment of Metabolic AlterationsView all 6 articles
Muscle Quality Index and Hyperuricemia: Adipose Tissue as a Mediator
Provisionally accepted
- Taihe Hospital, Hubei University of Medicine, Shiyan, China
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The relationship between the Muscle Quality Index (MQI) and hyperuricemia remains incompletely defined, and additional studies are necessary to elucidate the mediating role of adipose tissue in this association.Methods: This study utilized data from the 2011-2014 National Health and Nutrition Examination Survey (NHANES) and included 5,198 adults. MQI was calculated as the ratio of maximum handgrip strength to appendicular skeletal muscle mass (ASM), and adipose tissue parameters included body fat percentage (BF%) and visceral fat mass (VFM). To examine the link between MQI and hyperuricemia, multiple logistic regression models were employed, and generalized additive models were utilized to assess potential non-linear patterns. Mediation analysis was performed to assess the mediating effect of adipose tissue, and sensitivity analyses, which involved altering the thresholds for hyperuricemia and excluding individuals with major chronic conditions, were carried out to verify the consistency of the results.When treated as a continuous variable, MQI demonstrated a strong inverse association with hyperuricemia. Each one-unit increment in MQI corresponded to a 50% decrease in the odds of hyperuricemia (OR: 0.50, 95% CI: 0.43-0.57). Quartile-based analysis revealed that individuals in the highest MQI quartile had a 68% lower odds of developing hyperuricemia compared to those in the lowest quartile (OR: 0.32, 95% CI: 0.25-0.41). Subgroup analyses confirmed this negative correlation across various strata, and sensitivity analyses showed consistent results. Mediation analysis indicated that BF% and VFM explained 49.32% and 53.62% of the association between MQI and hyperuricemia, respectively.This study reveals a significant negative correlation between MQI and hyperuricemia, mediated by adipose tissue. These findings suggest that improving muscle quality and managing adipose tissue could offer new strategies for mitigating hyperuricemia and promoting better public health outcomes.
Keywords: muscle quality index, Serum uric acid, SUA, Hyperuricemia, Body fat percentage, Visceral fat mass, Adipose Tissue, NHANES
Received: 18 Jan 2025; Accepted: 12 May 2025.
Copyright: © 2025 Shao, Wang, Jiang, Shao, Liu, Li and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Longti Li, Taihe Hospital, Hubei University of Medicine, Shiyan, China
Huiqin Zhong, Taihe Hospital, Hubei University of Medicine, Shiyan, China
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