RISK FACTORS ASSOCIATED WITH LOW BONE MINERAL DENSITY AND CHILDHOOD OSTEOPOROSIS IN A POPULATION UNDERGOING SKELETAL GROWTH: A CROSS-SECTIONAL ANALYTIC STUDY

Berta Magallares-López^1,2,3*Dacia Cerdà⁴Jocelyn Betancourt^3,5Gloria Fraga^3,5Hye Sang Park^1,3Helena Codes-Méndez^1,3*Estefanía Quesada-Masachs^2,6Mireia López-Corbeto⁶Montserrat Torrent⁵Ana Marín⁷Silvia Herrera^3,7Ignasi Gich^3,8,9Susana Boronat^3,5Jordi Casademont¹⁰Hector Corominas^1,3Jorge Malouf⁷

• ¹Department of rheumatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
• ²Department of rheumatology, Hospital Universitari Dexeus-Grupo Quirón Salud, Barcelona, Balearic Islands, Spain
• ³Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Balearic Islands, Spain
• ⁴Department of Rheumatology, Hospital Sant Joan Despí Moisès Broggi, Barcelona, Balearic Islands, Spain
• ⁵Department of Pediatrics, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Catalonia, Spain
• ⁶Department of Pediatric Rheumatology, Vall d'Hebrón Barcelona Hospital Campus, Barcelona, Balearic Islands, Spain
• ⁷Department of Mineral Metabolism Unit - Internal Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Balearic Islands, Spain
• ⁸Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Madrid Community, Spain
• ⁹Department of Clinical Epidemiology and Public Health, Hospital de la Santa Creu i Sant Pau, Barcelona, Balearic Islands, Spain
• ¹⁰Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Barcelona, Balearic Islands, Spain

Background:Early identification of risk factors for low bone mass for chronological age (LBMca) and childhood osteoporosis (cOP) in patients undergoing skeletal growth is essential to mitigate long-term skeletal complications. cOP is diagnosed when LBMca (BMD Z-score ≤2) is accompanied by a clinically significant fracture history, or when vertebral fragility fractures are present.Methods:Patients under 21 years of age with at least one risk factor for LBMca (malabsorption syndrome, chronic inflammatory diseases, hematological diseases, endocrinopathies, drugs that affect bone metabolism, or insufficient calcium intake) were included. Data on fractures history and physical activity levels were collected. Spine and whole-body dual-energy x-ray absorptiometry (DXA) and vertebral morphometry were performed. Age-adjusted linear regression analysis evaluated associations between bone mineral density (BMD) and risk factors.Results:A total of 103 patients were included (mean age 9.8 years; 52.4% female), and 96.1% had more than two risk factors. The prevalence of LBMca was 10.5% and the prevalence of cOP was 4.8%. Vertebral BMD was positively associated with male sex. Whole body BMD was negatively associated with sedentary lifestyle and fracture history. Total body less head BMD showed negative associations with current steroid treatment, sedentary lifestyle, and history of fractures.Conclusions:Pediatric populations at risk of LBMca or cOP often have multiple risk factors, notably modifying ones such as physical inactivity. Up to 10.5% of children with risk factors present LBMca and 4.8% have an undiagnosed or unknown cOP. Longitudinal studies are warranted to understand the long-term impact of the identified risk factors, including age, sex, sedentary lifestyle, ethnicity and vitamin D status, on bone health.