REVIEW article
Front. Endocrinol.
Sec. Endocrinology of Aging
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1592491
Exerkines and Myokines in Aging Sarcopenia
Provisionally accepted
- 1Guangzhou Sport University, Guangzhou, China
- 2Graduation School, Guangzhou Sport University, Gudong Guangzhou, China
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Aging sarcopenia is an unavoidable condition that affects the majority of older adults in their later years. Exercise has been extensively research as an effective intervention for enhancing sarcopenia. In particular, the release of exerkines and myokines during physical activity exert beneficial effects on the body. Which as mediators offer a novel therapeutic strategy for elucidating how exercise enhances skeletal muscle mass and function. In this review article, we summarizes that exerkines exert protective effects on aging skeletal muscle mainly through the following mechanisms: (1) Mediating energy diversion to skeletal muscle, ensuring more energy supply to the muscle; (2) Enhancing the activity of skeletal muscle satellite cells to promote muscle repair and regeneration; (3) Upregulating the expression of genes associated with muscle regeneration and promotes; at the same time, inhibiting the expression of those genes that contribute to the atrophy of skeletal muscle; (4) Improving the function of the neuromuscular junction to improve the neural control of skeletal muscle. These combined effects constitute the protective mechanism of myokines on aging skeletal muscle.
Keywords: Sarcopenia, Exerkines, Myokines, Exercise, skeletal muscle
Received: 21 Mar 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Wang, He, Chen, Wang, Wang, Zhu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoguang Liu, Guangzhou Sport University, Guangzhou, China
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