Optimized Prediction of Diabetes Complications Using Ensemble Learning with Bayesian Optimization: A Cost-Efficient Laboratory-Based Approach

Xiaohan Li¹Yifan Wang¹Dapeng Yan^2*Yefei Zhu¹

• ¹Nanjing Medical University, Nanjing, Jiangsu Province, China
• ²Nanjing University of Posts and Telecommunications, Nanjing, Jiangsu Province, China

Background and Objective: The increasing global prevalence of diabetes has led to a surge in complications, significantly burdening healthcare systems and affecting patient quality of life.Early prediction of these complications is critical for timely intervention, yet existing models often rely heavily on clinical indicators while underutilizing fundamental laboratory test parameters. This study aims to bridge this gap by leveraging the 12 most frequently tested laboratory indicators in diabetic patients to develop an optimized predictive model for diabetes complications.Methods: A comprehensive dataset was established through meticulous data collection from a high-volume tertiary hospital, followed by extensive data cleaning and classification. Various machine learning classifiers, including Random Forest, XGBoost, Support Vector Machine (SVM), and Multilayer Perceptron (MLP), were trained on this dataset to evaluate their predictive performance. We further introduced an ensemble learning model with Bayesian optimization to enhance accuracy and cost-efficiency. Additionally, feature importance analysis was conducted to refine the model by reducing testing costs while maintaining high predictive accuracy.Results: Our ensemble model with Bayesian optimization demonstrated superior performance, achieving over 90% accuracy in predicting various diabetic complications, with an outstanding 98.50% accuracy and 99.76% AUC for diabetic nephropathy. Feature correlation analysis enabled a refined model that not only improved predictive accuracy but also reduced overall medical costs by 2.5% through strategic feature elimination. Conclusions: This study makes three key contributions: (1) Development of a high-quality dataset based on fundamental laboratory indicators, (2) Creation of a highly accurate predictive model 1 Sample et al. Running Title using ensemble learning and Bayesian optimization, particularly excelling in diabetic nephropathy prediction, and (3) Implementation of a cost-efficient diagnostic approach that reduces testing expenses without compromising accuracy. The proposed model provides a strong foundation for future research and practical clinical applications, demonstrating the potential of integrating machine learning with cost-conscious medical testing.