REVIEW article
Front. Endocrinol.
Sec. Bone Research
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1600218
This article is part of the Research TopicMetabolic and Biomechanical Factors in Bone Fragility: New Frontiers in Understanding and Managing OsteoporosisView all articles
Roles of Myokines in Osteoporosis under Physiological and Diabetic Conditions
Provisionally accepted
- 1Zhejiang University, Hangzhou, China
- 2Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
- 3First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The musculoskeletal system is not only closely linked anatomically, but musclederived myokines also play a crucial role in bone development and metabolism beyond the effects of mechanical force. Myokines are essential in muscle-bone crosstalk, significantly influencing bone remodeling and metabolism. In the context of diabetes, including both type 1 (T1DM) and type 2 (T2DM), changes in myokine expression have a substantial impact on bone metabolism, leading to an increased risk of osteoporosis. This review provides a comprehensive examination of the roles of key myokines in regulating osteoblast lineage cells and osteoclast activity. We highlight how different myokines can either promote or inhibit bone formation and resorption and discuss their altered expression levels under diabetic conditions. A deeper understanding of the multifaceted roles of myokines may open new avenues for treating osteoporosis, particularly in diabetic patients.
Keywords: Myokines, diabetes, bone metabolism, Osteoporosis, Osteoblast lineage cells, Osteocalst, T1DM, T2DM
Received: 26 Mar 2025; Accepted: 20 May 2025.
Copyright: © 2025 JI, Hu, Xu and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wanlei Yang, First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310003, Zhejiang Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.