Metabolic and Biomechanical Factors in Bone Fragility: New Frontiers in Understanding and Managing Osteoporosis

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REVIEW

Accepted on 05 Nov 2025

Macrophages in Osteoporotic Fractures: From Immunometabolic Mechanisms to Precision Therapeutic Approaches

Jiahui Xing
Haibo Li
Honggang Xia
Lilei Xia
Hongzhou Zhao

ORIGINAL RESEARCH

Accepted on 04 Nov 2025

A Threshold of β-CTX (0.3 ng/mL) with Low Estradiol Identifies High-Risk Perimenopausal Women for Bone Loss: A Cross-Sectional Study

Xufen Feng
Wenjun Xiao
Rongshan Zhang

ORIGINAL RESEARCH

Published on 24 Oct 2025

Exploring the S-shaped relationship between triglyceride-glucose index and serum uric acid levels in individuals with osteoporotic fracture

Xiao-jie Zhou
Min-zhe Xu
Ya-qin Gong
Jian Jin
Ke Lu
Chong Li

doi 10.3389/fendo.2025.1639818

519 views

ORIGINAL RESEARCH

Published on 14 Oct 2025

Association between triglyceride glucose-body mass index with all-cause and cardiovascular mortality in adults with osteoporosis: a prospective study

Yuhao Li
Xiaowan Xie
Yazhou Liu
Haoran Sun
Zhaoqi Gong
Wenbo Ding

doi 10.3389/fendo.2025.1649964

853 views

STUDY PROTOCOL

Published on 02 Oct 2025

Sustainable innovation with a method based on peripheral mononuclear cells to screen, monitor and stratify the population at risk of osteoporosis and fractures – a multicenter cross-sectional trial protocol

Francesca Salamanna
Silvia Brogini
Alberto Di Martino
Nicola Baldini
Agostino Gaudio
Pietro Castellino
Deyanira Contartese
Chiara Di Censo
Gianluca Giavaresi
1 more
Milena Fini

doi 10.3389/fendo.2025.1647800

676 views

ORIGINAL RESEARCH

Published on 13 Aug 2025

The novel organoselenium compound 4aa ameliorates osteoporosis by modulating gut microbiota composition and fecal metabolite profiles

Chaoming Hu
Yichi Zhang
Yao Wu
Junhao Tu
Mengjia Yi
Yixin Mao
Yang Chen
Xiaoyu Sun
Zengqiang Song
2 more
Bin Li

doi 10.3389/fendo.2025.1623933

1,550 views

ORIGINAL RESEARCH

Published on 04 Aug 2025

Zoledronic acid and denosumab are associated with similar fracture incidence and mortality in patients with type 2 diabetes: a population-based cohort study

Vanessa Rouach
Hilary Gortler
Yona Greenman
Gabriel Chodick
Inbal Goldshtein

doi 10.3389/fendo.2025.1590472

1,984 views

REVIEW

Published on 11 Jun 2025

Roles of myokines in osteoporosis under physiological and diabetic conditions

Xing Ji
Xinhua Hu
Taotao Xu
Wanlei Yang

doi 10.3389/fendo.2025.1600218

2,423 views
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Frontiers in Endocrinology

Bone Research
Clinical Diabetes

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Frontiers in Medicine
- Nephrology
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Articles

Macrophages in Osteoporotic Fractures: From Immunometabolic Mechanisms to Precision Therapeutic Approaches

A Threshold of β-CTX (0.3 ng/mL) with Low Estradiol Identifies High-Risk Perimenopausal Women for Bone Loss: A Cross-Sectional Study

Exploring the S-shaped relationship between triglyceride-glucose index and serum uric acid levels in individuals with osteoporotic fracture

Association between triglyceride glucose-body mass index with all-cause and cardiovascular mortality in adults with osteoporosis: a prospective study

Sustainable innovation with a method based on peripheral mononuclear cells to screen, monitor and stratify the population at risk of osteoporosis and fractures – a multicenter cross-sectional trial protocol

The novel organoselenium compound 4aa ameliorates osteoporosis by modulating gut microbiota composition and fecal metabolite profiles

Zoledronic acid and denosumab are associated with similar fracture incidence and mortality in patients with type 2 diabetes: a population-based cohort study

Roles of myokines in osteoporosis under physiological and diabetic conditions

Frontiers in Endocrinology

Bone Research

Clinical Diabetes

Participating Journals

Frontiers in Medicine

Nephrology