REVIEW article
Front. Endocrinol.
Sec. Pediatric Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1615712
This article is part of the Research TopicMusculoskeletal Markers of Healthy Development in YouthView all articles
Advances in the Application of Bone Turnover Markers for Pediatric Growth and Developmental Disorders: A Review
Provisionally accepted
- 1University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
- 2Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
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Bone turnover markers (BTMs) are biomedical indicators used to assess the bone metabolism processes reflecting the activity of osteoblasts and osteoclasts. During childhood and adolescence, bone metabolism is highly active, leading to distinct levels and trends of BTMs compared with those of adults. BTMs correlate significantly with age, gender and environmental factors, making them valuable for evaluating bone health and developmental trajectories in pediatric populations. Due to the non-invasive characters and dynamic monitoring capabilities, BTMs are increasingly employed in research and clinical practice. Preliminary observations propose that BTMs demonstrate clinical utility in predicting fracture risk, enabling early diagnosis of osteoporosis and rickets, and monitoring therapeutic efficacy. However, Tracability of BTM mesurement results and limited pediatric reference intervals remain critical chanllenges. Further research is needed to expand our understanding of the their mechanisms and optimize clinical applications. This article reviews the physiological and pathological states in children, discusses the current dilemmas of clinical application, and highlights the future research prospects.
Keywords: bone turnover markers1, Children and adolescents2, bone metabolism3, pediareic bone health4, pediatric developmental disorders5
Received: 21 Apr 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Wang, Huang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yi Huang, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
Honghua Hu, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China
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