ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1632694
Screening of Biomarkers for Early Diagnosis of Trauma-induced Coagulopathy Based on Untargeted Metabolomics
Provisionally accepted
- Hunan Provincial People's Hospital, Changsha, China
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Objectives: Trauma-induced coagulopathy (TIC) is an acute coagulation disorder characterized by massive bleeding following trauma and is a leading cause of mortality. However, current clinical methods are inadequate for predicting TIC onset, and reliable biomarkers for early diagnosis are lacking. This study aimed to identify potential biomarkers with high sensitivity and specificity for TIC using an untargeted metabolomics approach. Methods: We analyzed serum samples from 54 trauma patients (27 with TIC and 27 without TIC) and 27 healthy controls. All samples were collected within 24 hours post-trauma. Metabolomic profiling was conducted using liquid chromatography-tandem mass spectrometry (LC-MS). Results: Metabolite profiles differed significantly between the TIC and non-TIC groups. Two metabolites, LysoPE(20:4(8Z,11Z,14Z,17Z)/0:0) (AUC = 0.933, 95% CI: 0.849–0.995) and LysoPE(0:0/18:2(9Z,12Z)) (AUC = 0.916, 95% CI: 0.818–0.914), were identified as potential biomarkers for distinguishing TIC. The diagnostic performance of these metabolites surpassed that of both conventional coagulation tests and admission assessment scores. Conclusion: Two LysoPE metabolites were identified as promising biomarkers for the early detection of TIC.
Keywords: Liquid chromatography-tandem mass spectrometry (LC-MS), lysophosphatidylethanolamine (LysoPE), Metabolomics, Trauma, trauma-induced coagulopathy (TIC)
Received: 21 May 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Xu, Ouyang, Shao, Yi, Liu, Huang, Wang, Zhang and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chaochao Tan, w2236@hunnu.edu.cn
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