REVIEW article
Front. Endocrinol.
Sec. Bone Research
This article is part of the Research TopicRecent Advances in the Management of Osteoporosis: Prevention, Diagnosis and TreatmentView all 13 articles
G-Protein Coupled Receptors Synergy in Bone Health: New Avenues for Osteoporosis Detection and In Vitro Modeling
Provisionally accepted
Julia Sopova1,2*
Olga Krasnova2
Julia D Kriukova2
Yana Olegovna Mukhamedshina3,4
Elena Zakirova3
Albert Rizvanov3,4
Olga Lesnyak5
Irina Neganova2*- 1Saint-Petersburg State University, Saint-Peterburg, Russia
- 2FGBUN Institut citologii Rossijskoj akademii nauk, Saint Petersburg, Russia
- 3Kazanskij federal'nyj universitet Institut fundamental'noj mediciny i biologii, Kazan, Russia
- 4Division of Medical and Biological Sciences, Academy of Sciences of the Republic of Tatarstan, Kazan, Russia
- 5Severo-Zapadnyj gosudarstvennyj medicinskij universitet imeni I I Mecnikova, Saint Petersburg, Russia
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Osteoporosis remains a substantial healthcare burden in modern times. Current diagnostic methods of osteoporosis detect changes in bone mineral density and microarchitecture, which have already occurred. It is critically important to develop methods of early diagnosis of osteoporosis to be able to plan early interventions in order to stop the disease progression. Genetic screening based on early osteoporosis marker genes appears to be a promising approach for early diagnosis and prevention. However, a significant gap exists in this area of knowledge. Recently, we identified a novel combination of three single nucleotide polymorphisms – FSHR (rs6166) AA, TSHR (rs1991517) CC, and ADRB2 (rs1042713) AA, with a high prevalence among osteoporotic patients. Subsequent functional studies using patient-derived mesenchymal stem cell lines revealed impaired osteogenic differentiation capacity. To clarify the role of these polymorphism combinations, this review first examines the physiological aspects of each receptor and the identified single nucleotide polymorphisms at the organismal level. It then analyzes their contribution to the dysregulation of bone remodeling, with a particular focus on osteoblastogenesis. Understanding these mechanisms opens up new opportunities for the development of early osteoporosis diagnosis and stratification of personalized treatments for patients.
Keywords: Osteoporosis, SNP, Bone Remodeling, Bone homeostasis, FSHR, TSHR, ADRB2
Received: 12 Aug 2025; Accepted: 10 Nov 2025.
Copyright: © 2025 Sopova, Krasnova, Kriukova, Mukhamedshina, Zakirova, Rizvanov, Lesnyak and Neganova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Julia Sopova, y.sopova@spbu.ru
Irina Neganova, irina.neganova@incras.ru
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