REVIEW article
Front. Endocrinol.
Sec. Endocrinology of Aging
Volume 16 - 2025 | doi: 10.3389/fendo.2025.1689787
This article is part of the Research TopicEndocrinology of Aging: Advances in Molecular Biology and Metabolic DiseasesView all articles
Inflammation and Vasopressin Hypersecretion in Aging
Provisionally accepted
- 1Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
- 2Sirius University of Science and Technology, Sirius Federal Territory, Sochi, Russia
- 3Department of Medical Elementology, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia
- 4Nazarbayev University School of Medicine, Astana, Kazakhstan
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Low-grade inflammation, both hypothalamic and systemic, sensitizes the neuroendocrine response to osmotic stimuli whose proximate cause is chronic underhydration common in older adults due to diminished thirst perception. These events drive persistent vasopressin (VP) release. VP exerts antidiuretic effects via renal V2 receptors and functions as a stress hormone through widely expressed V1a and V1b receptors. These latter actions are central to inappropriate activation of the hypothalamic-pituitary-adrenal axis observed in aging, as VP stimulates secretion of the adrenocorticotropic hormone. The resulting sustained elevations in circulating VP and cortisol contribute to metabolic, renal, and cardiovascular disorders that compromise health and lifespan in older individuals. This review reconciles the concept of microinflammation with recent molecular insights into hypothalamic osmosensitivity, proposing a model for the maladaptive hypersecretion of vasopressin in advanced age. This framework may inform the development of targeted interventions to normalize VP secretion, thereby mitigating the metabolic, cardiovascular, and renal diseases that disproportionately affect older adults.
Keywords: vasopressin, antidiuretic hormone, cytokine, Interleukin - 1 β, Interleukin-6, Inflammaging, Microinflammation
Received: 20 Aug 2025; Accepted: 22 Sep 2025.
Copyright: © 2025 Mutig, Lebedeva and Singh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kerim Mutig, kmutig@gmail.com
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