ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Monocyte-to-Lymphocyte Ratio as a Predictor of Left Ventricular Aneurysm in acute STEMI Patients
Provisionally accepted
- 1The Central Hospital of Wuhan, Wuhan, China
- 2Wuhan University Renmin Hospital, Wuhan, China
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Background The monocyte-to-lymphocyte ratio (MLR) has emerged as a novel marker of inflammation. Nevertheless, its potential utility in predicting the development of left ventricular aneurysm (LVA) remains unexplored. This study aims to investigate the association between MLR and the risk of LVA in patients presenting with acute ST-segment elevation myocardial infarction (STEMI). Methods A total of 551 patients were enrolled in the first cohort, and 471 patients were included in the validation cohort. To evaluate the predictive value of MLR for LVA, multivariable logistic regression analysis, restricted cubic splines (RCS) analysis, and receiver operating characteristic (ROC) analysis were employed. Results The prevalence of LVA were 14.5% in the first cohort and 13.6% in the validation cohort. Multivariable logistic regression analysis revealed that individuals in the highest quartile of MLR (Q4) exhibited a significantly increased risk of LVA formation compared to those in the lowest quartile (Q1) in both cohorts (First cohort: OR= 3.07, 95% CI= 1.33 - 7.08, P= 0.009; Validation cohort: OR= 3.55, 95% CI= 1.34 - 9.42, P= 0.011). RCS analysis identified a positively nonlinear association in the first cohort and positively linear association in the validation cohort between MLR and the risk of LVA (overall P< 0.05). Furthermore, the discriminative ability of MLR for LVA is 0.69 in the first cohort and 0.71 in the validation cohort, exceeding that of both monocyte and lymphocyte alone. Subgroup analyses further substantiated the robustness of our findings. Conclusion An elevated MLR was independently linked to an increased risk of LVA development in patients with STEMI who received primary PCI. This readily available inflammatory index may offer supplementary prognostic information and could be considered for inclusion in future risk stratification models.
Keywords: Acute ST-segment elevation myocardial infarction, Left ventricular aneurysm, Monocyte-to-lymphocyte ratio, predictor, risk
Received: 10 Sep 2025; Accepted: 11 Dec 2025.
Copyright: © 2025 Dong, Wu, Lin, Wang, Zhao and chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hu Dong
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