ORIGINAL RESEARCH article
Front. Endocrinol.
Sec. Cardiovascular Endocrinology
Association between Intrinsic Capacity, Changes in Intrinsic Capacity, and Cardiometabolic Multimorbidity: Results from Three Prospective Cohort Studies
Provisionally accepted
- Shanghai Tenth People's Hospital, Tongji University, Shanghai, China
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Background: Intrinsic capacity (IC)is closely associated with cardiometabolic health in middle-aged and older adults. The purpose of this study was to determine the associations of baseline IC, cumulative IC scores, and their dynamic changes with the risk of incident cardiometabolic multimorbidity (CMM). Methods: Using data from three prospective cohorts, the China Health and Retirement Longitudinal Study (CHARLS), the English Longitudinal Study of Ageing (ELSA), and the Health and Retirement Study (HRS), participants who met the eligibility criteria were included in this study. Kaplan-Meier curves and Cox models analyzed risk trends and associations. Results: A total of 11,916 participants were included based on the inclusion and exclusion criteria. At baseline, the risk of CMM in the injured group was significantly higher than that in the non-injured group(Pooled: HR = 1.40, 95% CI 1.30-1.52, P<0.001); Cumulative IC scores showed a graded association with CMM risk: individuals with moderately reduced scores (≈1 SD below intact) had higher risk (HR = 1.22, 95% CI 1.09–1.36), and those with substantially reduced scores (>1 SD below intact) had even higher risk (HR = 1.61, 95% CI 1.47–1.78). For dynamic changes, CMM risk was significantly higher in persistent impairment and decline groups; even the improvement group had higher risk than the no-decline group (Decline: HR = 1.25, 95% CI 1.10-1.42, P<0.001; Improvement: HR = 1.28, 95% CI 1.13-1.45, P<0.001; Persistent impairment: HR = 1.63, 95% CI 1.48-1.80, P<0.001). Conclusions: IC and its changes relate to CMM risk. Even with IC improvement, risk remains higher than in those with intact IC. Precise strategies to delay IC decline and individualized interventions are needed for CMM control.
Keywords: Aging, cardiometabolic multimorbidity, DynamicChanges, Intrinsic capacity, prospective cohort study
Received: 04 Nov 2025; Accepted: 03 Dec 2025.
Copyright: © 2025 Wang, Wang, Tang, Li, Lu, Yu, Liu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fei Liu
Xiaoping Zhu
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