REVIEW article
Front. Endocrinol.
Sec. Clinical Diabetes
This article is part of the Research TopicFrontiers in Diagnostic and Therapeutic approaches in Diabetic Sensorimotor Neuropathy, Volume IIView all 6 articles
The Role of Clinical Laboratory Parameters in Diabetic Neuropathy: Correlations and Recent Advances
Provisionally accepted
- 1Department of Endocrinology, Hebei Medical University Third Hospital, Shijiazhuang, China
- 2Department of Physiology, School of Basic Medicine,, Hebei Medical University, Shijiazhuang, China
- 3Department of Ophthalmology, Hebei Medical University Third Hospital, Shijiazhuang, China
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Diabetic neuropathy affects approximately 50% of patients with diabetes, causing significant health issues and reducing quality of life. This review examined the associations between diabetic neuropathy and various laboratory parameters, including metabolic indicators, renal and hepatic function parameters, inflammatory biomarkers, thyroid hormones and vitamins. By summarizing the latest evidence on these easily accessible clinical parameters, the article aims to improve risk stratification, enable earlier diagnosis and develop personalized therapeutic strategies, emphasizing the potential of multi-parameter biomarker integration to optimize patient care.
Keywords: biomarkers, Clinical laboratory parameters, Diabetic neuropathy, early diagnosis, risk stratification
Received: 11 Nov 2025; Accepted: 11 Feb 2026.
Copyright: © 2026 Guo, Lou, Li, Tian, Gao, Ma, Liu and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xinli Jiang
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