MINI REVIEW article
Front. Endocrinol.
Sec. Cancer Endocrinology
This article is part of the Research TopicCancer Biomarkers: Molecular Insights into Diagnosis, Prognosis, and Risk Prediction: Volume IIView all 16 articles
Disulfidptosis and Androgenic Cancers: From Molecular Mechanisms to Clinical Applications and Future Translational Research
Provisionally accepted
- 1Gansu University of Chinese Medicine, Lanzhou, China
- 2Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China
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Disulfidptosis, a newly discovered form of programmed cell death, has garnered significant attention in tumor biology and reproductive system research in recent years, particularly demonstrating importance in urological cancer studies.Prostate cancer, testicular cancer, and bladder cancer are highly prevalent malignant tumors among men globally. Modern medical research reveals their complex pathogenesis and the limited efficacy of traditional treatments, necessitating the identification of novel therapeutic targets. Disulfidptosis influences tumor cell survival and death by regulating the formation and cleavage of intracellular protein disulfide bonds, highlighting its pivotal role in tumorigenesis and progression.This paper systematically reviews the molecular mechanisms of disulfidptosis, elucidates its regulatory role in male cancer cells—including key regulatory genes and therapeutic target potential—and discusses its application value and challenges as a potential therapeutic target based on clinical research. It aims to deepen understanding of disulfidptosis regulation, provide new insights and strategies for future precision treatment and clinical translation of male cancers, and drive innovation in related therapeutic approaches.
Keywords: clinical applications, disulfidptosis, Future Transformation, male reproductive cancers, Molecular mechanisms
Received: 09 Jan 2026; Accepted: 09 Feb 2026.
Copyright: © 2026 Wang, Zhao, Li, CHANG, Zhao and Xing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xueyang Wang
Xiping Xing
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