Frontiers in Genetics

Original Research

Published on 27 Oct 2025

Identification and functional analysis of a novel CSNK2A1 frameshift variant in stillbirth

in Statistical Genetics and Methodology

Nannan Zhang
Miao Han
Tong Zhao
Xinxin Tang
Zhiwei Wang
Yunqiu Du
Leilei Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1692704

1,829 views

Case Report

Published on 27 Oct 2025

Prenatal diagnosis of a de novo pathogenic HNRNPK variant in a Chinese fetus with abnormal ultrasound soft markers: a case report

in Human and Medical Genomics

Yuying Zhu
Zhen Yang
Qiumin Zhu
Ke Wu
Junying He
Hongmei Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1661743

1,800 views

Original Research

Published on 27 Oct 2025

Identification of druggable targets in melanoma by multi-omics Mendelian randomization integrated with transcriptomic and spatial analysis

in Applied Genetic Epidemiology

Jiahua Xing
Mingyong Yang
Muzi Chen
Ran Tao

Frontiers in Genetics

doi 10.3389/fgene.2025.1657356

1,890 views

Correction

Published on 27 Oct 2025

Correction: Effectiveness of non-invasive chromosomal screening for normal karyotype and chromosomal rearrangements

in ELSI in Science and Genetics

Bo-Lan Sun
Yong Wang
Sixi Wen
Liang Zhou
Chun-Hui Zhang
Ze-Xuan Wu
Jie Qiao
Qing-Yuan Sun
Ya-Xin Yao
Jing Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1711906

1,296 views

Correction

Published on 24 Oct 2025

Correction: Genome-wide association study of drought tolerance traits in sugar beet germplasms at the seedling stage

in Genomics of Plants and the Phytoecosystem

Wangsheng Li
Ming Lin
Jiajia Li
Dali Liu
Wenbo Tan
Xilong Yin
Yan Zhai
Yuanhang Zhou
Wang Xing

Frontiers in Genetics

doi 10.3389/fgene.2025.1685028

902 views

Case Report

Published on 24 Oct 2025

Case Report: Adenylosuccinate lyase deficiency type I caused by splicing disruption due to a novel missense variant in the ADSL gene

in Human and Medical Genomics

Artem Borovikov
Ksenia Davydenko
Aysylu Murtazina
Artem Sharkov
Ilya Kanivets
Alexandra Filatova
Mikhail Skoblov

Frontiers in Genetics

doi 10.3389/fgene.2025.1670299

1,739 views

Review

Published on 24 Oct 2025

Advances in RNA-based therapeutics: current breakthroughs, clinical translation, and future perspectives

in RNA

Sarbjeet Kaur Makkar

Frontiers in Genetics

doi 10.3389/fgene.2025.1675209

19,127 views
2 citations

Original Research

Published on 23 Oct 2025

Multi-omics identification and validation of oxidative phosphorylation–related hub genes in schizophrenia

in Computational Genomics

Yu Zhou
Shuang Zhang
Yao-Xia Liu
Xin Dai
Ting Zhang
Xiao-Tao Xu
Sheng-Nan Deng
Min-Yan Yang
Zhen Fan

Frontiers in Genetics

doi 10.3389/fgene.2025.1690947

2,119 views

Original Research

Published on 23 Oct 2025

Non-polar components in PM2.5 increase matrix remodeling of CRS by up-regulating CEMIP in nasal fibroblasts

in Predictive Toxicology and Exposomics

Jiayao Zhou
Ying Zhu
Huilin Hu
Ru Tang
Shiyao Zhang
Yuelong Gu
Song Mao
Shilei Pu
Hai Lin
Yue Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1672729

2,122 views

Review

Published on 23 Oct 2025

Single-cell transcriptomics in metastatic breast cancer: mapping tumor evolution and therapeutic resistance

in Cancer Genetics and Oncogenomics

Xu Han
Xin Li
Ling Bai
Gangling Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1669741

3,862 views

Case Report

Published on 23 Oct 2025

Case Report: a novel missense variant of FGD5 in a family with tetralogy of Fallot

in Genetics of Common and Rare Diseases

Meng-Wei Liu
Yi Dong
Rong Xiang
Liping Wu

Frontiers in Genetics

doi 10.3389/fgene.2025.1663959

2,017 views

Correction

Published on 23 Oct 2025

Correction: Heat shock protein 27 phosphorylation state is associated with cancer progression

in Systems Biology Archive

Maria Katsogiannou
Claudia Andrieu
Palma Rocchi

Frontiers in Genetics

doi 10.3389/fgene.2025.1703072

995 views

Original Research

Published on 23 Oct 2025

aiGeneR 3.0: an enhanced deep network model for resistant strain identification and multi-drug resistance prediction in Escherichia coli causing urinary tract infection using next-generation sequencing data

in Pharmacogenetics and Pharmacogenomics

Debasish Swapnesh Kumar Nayak
Abhilash Pati
Amrutanshu Panigrahi
Mudassir Khan
Bayan Alabdullah
Santanu Kumar Sahoo
Bibhuprasad Sahu
Abrar Almjally
Saurav Mallik
Tripti Swarnkar

Frontiers in Genetics

doi 10.3389/fgene.2025.1651917

2,323 views

Original Research

Published on 23 Oct 2025

A newly discovered Lnc-PDZD7-3 increased metastatic and proliferative potential of lung adenocarcinoma cells via modulating FN1/fibronectin signaling

in Cancer Genetics and Oncogenomics

Guodong Zhang
Jianbo Zhang
Fachang Yu
Xiaohe Hao

Frontiers in Genetics

doi 10.3389/fgene.2025.1618449

1,492 views
1 citation

Original Research

Published on 22 Oct 2025

A novel frameshift variant of PAX3 in a Chinese Yugur family with Waardenburg syndrome type 1

in Genetics of Common and Rare Diseases

Lupeng Zhan
Baicheng Xu
Dujuan Lin
Ya Wang
Panpan Bian

Frontiers in Genetics

doi 10.3389/fgene.2025.1679351

1,666 views

Original Research

Published on 22 Oct 2025

S100A10 knockdown exacerbates phenylephrine-induced cardiomyocyte hypertrophy via modulating mitochondrial oxidative phosphorylation

in Cytogenomics

Feixue Xu
Yajie Chen
Man Xu
Dan Li
Yinshan Lu
Meng Zhang
Jiahao Li
Wanyi Li
Yingying Guo

Frontiers in Genetics

doi 10.3389/fgene.2025.1610008

1,895 views
1 citation

Editorial

Published on 22 Oct 2025

Editorial: Decoding complexity: genomic, epigenomic, and environmental dynamics in developmental and neurogenetic disorders

in Epigenomics and Epigenetics

Alessandro Fiorenzano
Luísa Azevedo

Frontiers in Genetics

doi 10.3389/fgene.2025.1724013

1,450 views

Case Report

Published on 21 Oct 2025

Case Report: Clinical and molecular features of a radiosensitive autoimmune polyendocrine syndrome type 1 patient with oral carcinoma

in Genetics of Common and Rare Diseases

Asma Chikhaoui
Houda Hammami-Ghorbel
Dorra Najjar
Semia Zarraa
Safia Yahiaoui
Davor Lessel
Houda Yacoub-Youssef

Frontiers in Genetics

doi 10.3389/fgene.2025.1588108

2,171 views

Original Research

Published on 21 Oct 2025

A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer

in Cancer Genetics and Oncogenomics

Xuming Hu
Ye Wei
Meiying Zhang
Chunfeng Dou
Liping Wang
Gul Zaib
Huixian Wu
Wang Guo
Xiaoyuan Wang
Shihao Chen

Frontiers in Genetics

doi 10.3389/fgene.2025.1552009

2,434 views

Original Research

Published on 21 Oct 2025

Recognition of HSPB8 as a potential therapeutic target for prostate cancer

in Cancer Genetics and Oncogenomics

Xun Fu
Yutao Wang
Hongjun Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1680674

2,028 views
1 citation

Original Research

Published on 21 Oct 2025

In vitro cell model to dilucidate the underlying molecular mechanism associated with ophthalmic manifestation of congenital disorders of glycosylation: studying an ALG2-CDG patient

in Genetics of Common and Rare Diseases

Marisa Angelica Cubilla
Ana Clara Sclausero
Mariano Bisbal
Carla Gabriela Asteggiano

Frontiers in Genetics

doi 10.3389/fgene.2025.1678103

1,933 views

Original Research

Published on 20 Oct 2025

DLL1 haploinsufficiency in prenatal brain anomalies: a retrospective analysis of 6q terminal deletions

in Cytogenomics

Tingting Ge
Xiaojuan Lin
Xinyuan Tian
Xiaoyu Song
Bingbo Zhou
Ling Hui
Xiaozhuan Wang
Zhiqiang Zhang
Chuan Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1640775

1,896 views

Case Report

Published on 17 Oct 2025

Case Report: von Hippel-Lindau (VHL) disease: a young female presenting with multiple organ tumors

in Genetics of Common and Rare Diseases

Jingyuan Li
Yun Ti
Xiao Yang
Keqiang Yan
Tongshuai Chen
Tao Guo
Qin Hu
Cheng Zhang
Peili Bu

Frontiers in Genetics

doi 10.3389/fgene.2025.1676039

2,209 views

Original Research

Published on 17 Oct 2025

Genetic and clinical landscape of Duchenne muscular dystrophy in Guatemala: insights from a national study

in Genetics of Common and Rare Diseases

M. Orozco
E. Kestler
G. Ramirez
G. Silva
J. Cabrera
S. De la Vega
A. Al Khleifat

Frontiers in Genetics

doi 10.3389/fgene.2025.1595423

2,426 views
1 citation

16,578 articles

articles

Identification and functional analysis of a novel CSNK2A1 frameshift variant in stillbirth

Prenatal diagnosis of a de novo pathogenic HNRNPK variant in a Chinese fetus with abnormal ultrasound soft markers: a case report

Identification of druggable targets in melanoma by multi-omics Mendelian randomization integrated with transcriptomic and spatial analysis

Correction: Effectiveness of non-invasive chromosomal screening for normal karyotype and chromosomal rearrangements

Correction: Genome-wide association study of drought tolerance traits in sugar beet germplasms at the seedling stage

Case Report: Adenylosuccinate lyase deficiency type I caused by splicing disruption due to a novel missense variant in the ADSL gene

Advances in RNA-based therapeutics: current breakthroughs, clinical translation, and future perspectives

Multi-omics identification and validation of oxidative phosphorylation–related hub genes in schizophrenia

Non-polar components in PM2.5 increase matrix remodeling of CRS by up-regulating CEMIP in nasal fibroblasts

Single-cell transcriptomics in metastatic breast cancer: mapping tumor evolution and therapeutic resistance

Case Report: a novel missense variant of FGD5 in a family with tetralogy of Fallot

Correction: Heat shock protein 27 phosphorylation state is associated with cancer progression

aiGeneR 3.0: an enhanced deep network model for resistant strain identification and multi-drug resistance prediction in Escherichia coli causing urinary tract infection using next-generation sequencing data

A newly discovered Lnc-PDZD7-3 increased metastatic and proliferative potential of lung adenocarcinoma cells via modulating FN1/fibronectin signaling

A novel frameshift variant of PAX3 in a Chinese Yugur family with Waardenburg syndrome type 1

S100A10 knockdown exacerbates phenylephrine-induced cardiomyocyte hypertrophy via modulating mitochondrial oxidative phosphorylation

Editorial: Decoding complexity: genomic, epigenomic, and environmental dynamics in developmental and neurogenetic disorders

Case Report: Clinical and molecular features of a radiosensitive autoimmune polyendocrine syndrome type 1 patient with oral carcinoma

A novel mechanism by which c-MYC is aberrantly activated by epigenetic silencing of its antisense lncRNA in colon cancer

Recognition of HSPB8 as a potential therapeutic target for prostate cancer

In vitro cell model to dilucidate the underlying molecular mechanism associated with ophthalmic manifestation of congenital disorders of glycosylation: studying an ALG2-CDG patient

DLL1 haploinsufficiency in prenatal brain anomalies: a retrospective analysis of 6q terminal deletions

Case Report: von Hippel-Lindau (VHL) disease: a young female presenting with multiple organ tumors

Genetic and clinical landscape of Duchenne muscular dystrophy in Guatemala: insights from a national study