Frontiers in Genetics | Applied Genetic Epidemiology

Original Research

Published on 03 Feb 2026

Cross-trait genetic enrichment between GERD and psychiatric disorders in East Asian populations

in Applied Genetic Epidemiology

Zhihao Gao
Xianjin Wang
Zekun Liu
Fen Hu
Yidi Zhou
Kalim Ullah
Ruiwei Wang
Meng Zhang
Xiao Chang
Yongsen Wang

Frontiers in Genetics

doi 10.3389/fgene.2026.1770067

211 views

Original Research

Published on 03 Feb 2026

Population genetics of Plasmodium vivax with transmission and rebound in two endemic areas of Papua New Guinea

in Applied Genetic Epidemiology

Abebe A. Fola
Somya Mehra
Zahra Razook
Dulcie Lautu-Gumal
Elma Nate
Stuart Lee
Johanna Helena Kattenberg
Cristian Koepfli
James Kazura
Maria Ome-Kaius

Frontiers in Genetics

doi 10.3389/fgene.2025.1621920

625 views

Original Research

Published on 29 Jan 2026

Preliminary analysis of lifestyle and genetic factors for hyperuricemia and gout prevalence in the Yunnan Miao population of China

in Applied Genetic Epidemiology

Qiaohong Li
Salma Saeed Khan
Hao Yan
Weiying Kong
Lu Qin
Linmei Wu
Lingjie Li
Weijun Gong
Hua Zheng
Haiyan Li

Frontiers in Genetics

doi 10.3389/fgene.2026.1729712

696 views

Review

Accepted on 28 Jan 2026

Unravelling the genetic architecture of cardiovascular disease through structural variant detection with whole-genome sequencing

in Applied Genetic Epidemiology

Dona Nelanka Colombage
Eric K Moses
Phillip E Melton

Frontiers in Genetics

149 views

Review

Published on 26 Jan 2026

The mechanism and clinical significance of FKBP5 gene DNA methylation in various psychiatric, metabolic and tumor-related diseases

in Applied Genetic Epidemiology

Changliang Wang
Zhixiu Xia

Frontiers in Genetics

doi 10.3389/fgene.2026.1734673

670 views

Mini Review

Published on 14 Jan 2026

Ancestry gaps in cardiovascular GWAS: a multi-database review of African representation in genomic studies

in Applied Genetic Epidemiology

Diego A. Pomales-Matos
Mac Lyerly
Alejandro Rivera-Madera
Oswaldo L. Echevarría-Bonilla
Miguel Álvarez-Cortés
Saul E. Henriquez-Quiñones
Giselle M. Reyes-Sosa
Rafael A. Villanueva-Nogueras
Edwin G. Peña-Martínez

Frontiers in Genetics

doi 10.3389/fgene.2025.1647176

901 views

Brief Research Report

Accepted on 05 Jan 2026

Possible link between the apparently pathogenic FANCI variant and beneficial effects in sports

in Applied Genetic Epidemiology

Mariusz Berdyński
Małgorzata Borczyk
Kinga Humińska-Lisowska
Michal Korostynski
Paweł Cięszczyk
Cezary Zekanowski

Frontiers in Genetics

247 views

Perspective

Published on 05 Jan 2026

Monitoring diversity in genome-wide association studies requires measuring and reporting on immigration-related factors

in Applied Genetic Epidemiology

Yao Tu
Lindsay Fernandez-Rhodes

Frontiers in Genetics

doi 10.3389/fgene.2025.1725866

947 views

Original Research

Published on 13 Nov 2025

Distribution characteristics of MTHFR C677T gene polymorphism in Han nationality and women of childbearing age in 8 regions of Shaanxi province and a comparative analysis with other regions in China

in Applied Genetic Epidemiology

Ting Chen
Fei Song
Jinyao Sun
Jing Yi
Wenbing Ma

Frontiers in Genetics

doi 10.3389/fgene.2025.1693729

1,837 views

Original Research

Published on 27 Oct 2025

Identification of druggable targets in melanoma by multi-omics Mendelian randomization integrated with transcriptomic and spatial analysis

in Applied Genetic Epidemiology

Jiahua Xing
Mingyong Yang
Muzi Chen
Ran Tao

Frontiers in Genetics

doi 10.3389/fgene.2025.1657356

1,798 views

Original Research

Published on 17 Oct 2025

Association of APOA5 rs2075291 and CIDEB rs2144492 polymorphisms with hypertriglyceridemia in individuals with traditional Chinese medicine dampness syndrome: a case-control study

in Applied Genetic Epidemiology

Na Liu
Hongli Zeng
Xiangsheng Cai
Shuo Yang
Xinyan Chen
Guli Jiang
Jiamin Yuan
Jianxiong Cai
Hui Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1654501

1,454 views

Review

Published on 03 Oct 2025

The roles of serine protease inhibitors in dermatoses

in Applied Genetic Epidemiology

Zhenzhen Xiao
Yue Kang
Yunqian Zhuo
Rui Li
Yingjian Tan

Frontiers in Genetics

doi 10.3389/fgene.2025.1624512

4,195 views

Original Research

Published on 16 Sep 2025

The hidden in plain sight: global, regional, and national trends in the pediatric burden of Klinefelter syndrome, 1990–2021

in Applied Genetic Epidemiology

Guoqian Ma
Yuan Li
Fan Jia

Frontiers in Genetics

doi 10.3389/fgene.2025.1639699

3,943 views

Original Research

Published on 25 Aug 2025

Prevalence and penetrance of pathogenic and likely pathogenic LDLR and APOB gene variants linked to familial hypercholesterolemia and increased risk of ischemic heart disease

in Applied Genetic Epidemiology

I. K. Dzhumaniiazova
A. N. Meshkov
V.V. Daniel
M. V. Ezhov
E. A. Zelenova
U. V. Chubykina
D.A. Kashtanova
M. V. Ivanov
L. R. Matkava
O. I. Blinova

Frontiers in Genetics

doi 10.3389/fgene.2025.1589014

3,671 views

Original Research

Published on 15 Aug 2025

New therapeutic targets for endometriosis predicted through mendelian randomization analysis and case-control trials

in Applied Genetic Epidemiology

Linyao Zheng
Yue Yin
Xiaotong Wang
Baoju Wang
Ran Cui
Guangmei Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1631446

4,531 views

Brief Research Report

Published on 25 Jul 2025

Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care

in Applied Genetic Epidemiology

Georgios Ntritsos
Erez Ornan
Nir Gamliel
Gil Chernin
Arnold Pallay
Michael Chen
Efi Kessous
Eran Feldhay

Frontiers in Genetics

doi 10.3389/fgene.2025.1625822

3,160 views

Original Research

Published on 16 Jul 2025

Evaluation of diverse polygenic risk score models for lung cancer in a small-scale Chinese cohort

in Applied Genetic Epidemiology

Min Gao
Qiwen Zheng
Yue Jiang
Xiao Chang
Xin Zheng

Frontiers in Genetics

doi 10.3389/fgene.2025.1646997

2,746 views
1 citation

Original Research

Published on 02 Jul 2025

Clinical validation of an integrated risk assessment test incorporating genomic and non-genomic data for sporadic breast cancer in Colombia

in Applied Genetic Epidemiology

Harvy Mauricio Velasco Parra
Danny Styvens Cardona
Cesar Augusto Buitrago
Melisa Naranjo Vanegas
Sebastián Gutiérrez Hincapié
Carolina Jaramillo Jaramillo
Alicia Maria Cock-Rada
Carolina Benavides Duque
Clara Patricia Piedrahita
Catalina Bustamante

Frontiers in Genetics

doi 10.3389/fgene.2025.1556907

3,120 views
1 citation

Original Research

Published on 25 Jun 2025

Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers

in Applied Genetic Epidemiology

Youxing Li
Yaqin Pang
Dongshun Chen
Feiyu Lu
Hongyan Tian
Fengni Qin
Kuntao Wei
Ahmad Razali Bin Ishak
Mohd Shukri Bin Mohd Aris
Guangzi Qi

Frontiers in Genetics

doi 10.3389/fgene.2025.1591908

1,841 views

Original Research

Published on 24 Jun 2025

Shared genetic loci connect cardiovascular disease with blood pressure and lipid traits in East Asian populations

in Applied Genetic Epidemiology

Peng Zhong
Chumeng Zhang
Qinfeng Wu
Xiao Chang

Frontiers in Genetics

doi 10.3389/fgene.2025.1635378

2,982 views

Brief Research Report

Published on 18 Jun 2025

Data simulation to optimize frameworks for genome-wide association studies in diverse populations

in Applied Genetic Epidemiology

Jacquiline W. Mugo
Nicola Mulder
Emile R. Chimusa

Frontiers in Genetics

doi 10.3389/fgene.2025.1559496

2,682 views
1 citation

Original Research

Published on 12 Jun 2025

Highly multiplexed molecular inversion probe panel in Plasmodium falciparum targeting common SNPs approximates whole-genome sequencing assessments for selection and relatedness

in Applied Genetic Epidemiology

Karamoko Niaré
Rebecca Crudale
Abebe A. Fola
Neeva Wernsman Young
Victor Asua
Melissa D. Conrad
Pierre Gashema
Anita Ghansah
Stan Hangi
Deus S. Ishengoma

Frontiers in Genetics

doi 10.3389/fgene.2025.1526049

3,131 views
5 citations

Original Research

Published on 26 May 2025

Genetic association of ACE2 rs2285666 (C>T) and rs2106809 (A>G) and susceptibility to SARS-CoV-2 infection among the Ghanaian population

in Applied Genetic Epidemiology

Alexander Owusu Boakye
Christian Obirikorang
Anthony Afum-Adjei Awuah
Evans Asamoah Adu
Doris Winter
Eric Ebenezer Boham
Hakim Alani
Sylvester Kofi Newton
Nana Safi Toure Almoustapha
James Deke

Frontiers in Genetics

doi 10.3389/fgene.2025.1555515

3,076 views

Original Research

Published on 23 May 2025

The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells

in Applied Genetic Epidemiology

Jianguo Zhang
Yanhui Liu
Hailong Zhang
Lin Yang
Danjing Sun
Lili Xiao
Xiaoyun Wang
Xiangming Wu

Frontiers in Genetics

doi 10.3389/fgene.2025.1536672

1,958 views

449 articles

articles

Cross-trait genetic enrichment between GERD and psychiatric disorders in East Asian populations

Population genetics of Plasmodium vivax with transmission and rebound in two endemic areas of Papua New Guinea

Preliminary analysis of lifestyle and genetic factors for hyperuricemia and gout prevalence in the Yunnan Miao population of China

Unravelling the genetic architecture of cardiovascular disease through structural variant detection with whole-genome sequencing

The mechanism and clinical significance of FKBP5 gene DNA methylation in various psychiatric, metabolic and tumor-related diseases

Ancestry gaps in cardiovascular GWAS: a multi-database review of African representation in genomic studies

Possible link between the apparently pathogenic FANCI variant and beneficial effects in sports

Monitoring diversity in genome-wide association studies requires measuring and reporting on immigration-related factors

Distribution characteristics of MTHFR C677T gene polymorphism in Han nationality and women of childbearing age in 8 regions of Shaanxi province and a comparative analysis with other regions in China

Identification of druggable targets in melanoma by multi-omics Mendelian randomization integrated with transcriptomic and spatial analysis

Association of APOA5 rs2075291 and CIDEB rs2144492 polymorphisms with hypertriglyceridemia in individuals with traditional Chinese medicine dampness syndrome: a case-control study

The roles of serine protease inhibitors in dermatoses

The hidden in plain sight: global, regional, and national trends in the pediatric burden of Klinefelter syndrome, 1990–2021

Prevalence and penetrance of pathogenic and likely pathogenic LDLR and APOB gene variants linked to familial hypercholesterolemia and increased risk of ischemic heart disease

New therapeutic targets for endometriosis predicted through mendelian randomization analysis and case-control trials

Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care

Evaluation of diverse polygenic risk score models for lung cancer in a small-scale Chinese cohort

Clinical validation of an integrated risk assessment test incorporating genomic and non-genomic data for sporadic breast cancer in Colombia

Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers

Shared genetic loci connect cardiovascular disease with blood pressure and lipid traits in East Asian populations

Data simulation to optimize frameworks for genome-wide association studies in diverse populations

Highly multiplexed molecular inversion probe panel in Plasmodium falciparum targeting common SNPs approximates whole-genome sequencing assessments for selection and relatedness

Genetic association of ACE2 rs2285666 (C>T) and rs2106809 (A>G) and susceptibility to SARS-CoV-2 infection among the Ghanaian population

The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells