Frontiers in Genetics | Applied Genetic Epidemiology

Original Research

Published on 27 Oct 2025

Identification of druggable targets in melanoma by multi-omics Mendelian randomization integrated with transcriptomic and spatial analysis

in Applied Genetic Epidemiology

Jiahua Xing
Mingyong Yang
Muzi Chen
Ran Tao

Frontiers in Genetics

doi 10.3389/fgene.2025.1657356

518 views

Original Research

Published on 17 Oct 2025

Association of APOA5 rs2075291 and CIDEB rs2144492 polymorphisms with hypertriglyceridemia in individuals with traditional Chinese medicine dampness syndrome: a case-control study

in Applied Genetic Epidemiology

Na Liu
Hongli Zeng
Xiangsheng Cai
Shuo Yang
Xinyan Chen
Guli Jiang
Jiamin Yuan
Jianxiong Cai
Hui Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1654501

740 views

Review

Published on 03 Oct 2025

The roles of serine protease inhibitors in dermatoses

in Applied Genetic Epidemiology

Zhenzhen Xiao
Yue Kang
Yunqian Zhuo
Rui Li
Yingjian Tan

Frontiers in Genetics

doi 10.3389/fgene.2025.1624512

2,957 views

Original Research

Accepted on 30 Sep 2025

Population genetics of Plasmodium vivax in two endemic areas of Papua New Guinea with transmission decline and rebound

in Applied Genetic Epidemiology

Abebe Fola
Somya Mehra
Zahra Razook
Dulcie Lautu-Gumal
Elma Nate
Stuart Lee
Johanna Helena Kattenberg
Cristian Koepfli
James Kazura
Maria Ome-Kaius

Frontiers in Genetics

373 views

Original Research

Published on 16 Sep 2025

The hidden in plain sight: global, regional, and national trends in the pediatric burden of Klinefelter syndrome, 1990–2021

in Applied Genetic Epidemiology

Guoqian Ma
Yuan Li
Fan Jia

Frontiers in Genetics

doi 10.3389/fgene.2025.1639699

2,569 views

Original Research

Published on 25 Aug 2025

Prevalence and penetrance of pathogenic and likely pathogenic LDLR and APOB gene variants linked to familial hypercholesterolemia and increased risk of ischemic heart disease

in Applied Genetic Epidemiology

I. K. Dzhumaniiazova
A. N. Meshkov
V.V. Daniel
M. V. Ezhov
E. A. Zelenova
U. V. Chubykina
D.A. Kashtanova
M. V. Ivanov
L. R. Matkava
O. I. Blinova

Frontiers in Genetics

doi 10.3389/fgene.2025.1589014

2,876 views

Original Research

Published on 15 Aug 2025

New therapeutic targets for endometriosis predicted through mendelian randomization analysis and case-control trials

in Applied Genetic Epidemiology

Linyao Zheng
Yue Yin
Xiaotong Wang
Baoju Wang
Ran Cui
Guangmei Zhang

Frontiers in Genetics

doi 10.3389/fgene.2025.1631446

3,086 views

Brief Research Report

Published on 25 Jul 2025

Impact of polygenic risk score (PRS) for coronary artery disease on physician decision-making and patient care

in Applied Genetic Epidemiology

Georgios Ntritsos
Erez Ornan
Nir Gamliel
Gil Chernin
Arnold Pallay
Michael Chen
Efi Kessous
Eran Feldhay

Frontiers in Genetics

doi 10.3389/fgene.2025.1625822

2,261 views

Original Research

Published on 16 Jul 2025

Evaluation of diverse polygenic risk score models for lung cancer in a small-scale Chinese cohort

in Applied Genetic Epidemiology

Min Gao
Qiwen Zheng
Yue Jiang
Xiao Chang
Xin Zheng

Frontiers in Genetics

doi 10.3389/fgene.2025.1646997

2,109 views

Original Research

Published on 02 Jul 2025

Clinical validation of an integrated risk assessment test incorporating genomic and non-genomic data for sporadic breast cancer in Colombia

in Applied Genetic Epidemiology

Harvy Mauricio Velasco Parra
Danny Styvens Cardona
Cesar Augusto Buitrago
Melisa Naranjo Vanegas
Sebastián Gutiérrez Hincapié
Carolina Jaramillo Jaramillo
Alicia Maria Cock-Rada
Carolina Benavides Duque
Clara Patricia Piedrahita
Catalina Bustamante

Frontiers in Genetics

doi 10.3389/fgene.2025.1556907

2,349 views
1 citation

Original Research

Published on 25 Jun 2025

Association of the interaction between occupational hazard factors and IL-1β gene polymorphism with cognitive function in electrolytic aluminum workers

in Applied Genetic Epidemiology

Youxing Li
Yaqin Pang
Dongshun Chen
Feiyu Lu
Hongyan Tian
Fengni Qin
Kuntao Wei
Ahmad Razali Bin Ishak
Mohd Shukri Bin Mohd Aris
Guangzi Qi

Frontiers in Genetics

doi 10.3389/fgene.2025.1591908

1,345 views

Original Research

Published on 24 Jun 2025

Shared genetic loci connect cardiovascular disease with blood pressure and lipid traits in East Asian populations

in Applied Genetic Epidemiology

Peng Zhong
Chumeng Zhang
Qinfeng Wu
Xiao Chang

Frontiers in Genetics

doi 10.3389/fgene.2025.1635378

2,088 views

Brief Research Report

Published on 18 Jun 2025

Data simulation to optimize frameworks for genome-wide association studies in diverse populations

in Applied Genetic Epidemiology

Jacquiline W. Mugo
Nicola Mulder
Emile R. Chimusa

Frontiers in Genetics

doi 10.3389/fgene.2025.1559496

1,599 views
1 citation

Original Research

Published on 12 Jun 2025

Highly multiplexed molecular inversion probe panel in Plasmodium falciparum targeting common SNPs approximates whole-genome sequencing assessments for selection and relatedness

in Applied Genetic Epidemiology

Karamoko Niaré
Rebecca Crudale
Abebe A. Fola
Neeva Wernsman Young
Victor Asua
Melissa D. Conrad
Pierre Gashema
Anita Ghansah
Stan Hangi
Deus S. Ishengoma

Frontiers in Genetics

doi 10.3389/fgene.2025.1526049

2,293 views
3 citations

Original Research

Published on 26 May 2025

Genetic association of ACE2 rs2285666 (C>T) and rs2106809 (A>G) and susceptibility to SARS-CoV-2 infection among the Ghanaian population

in Applied Genetic Epidemiology

Alexander Owusu Boakye
Christian Obirikorang
Anthony Afum-Adjei Awuah
Evans Asamoah Adu
Doris Winter
Eric Ebenezer Boham
Hakim Alani
Sylvester Kofi Newton
Nana Safi Toure Almoustapha
James Deke

Frontiers in Genetics

doi 10.3389/fgene.2025.1555515

2,377 views

Original Research

Published on 23 May 2025

The role of E2F1 in promoting EIF4EBP1 transcription in cryptorchid mice: association with autophagy in germ cells

in Applied Genetic Epidemiology

Jianguo Zhang
Yanhui Liu
Hailong Zhang
Lin Yang
Danjing Sun
Lili Xiao
Xiaoyun Wang
Xiangming Wu

Frontiers in Genetics

doi 10.3389/fgene.2025.1536672

1,482 views