In the original article, Liang et al. () was not cited in the article. The citation has now been inserted in the Results, mRNA vaccine encoding H10 induces protective levels of antibodies, paragraph two and should read:
“All animals induced neutralizing antibody titers against HA above the accepted level of protection for seasonal influenza vaccination, as measured by hemagglutination inhibition assay (HAI) (Figure 1C) as we have reported earlier (, ). Although some of the animals in the ID group already showed titers at the protective level after the prime immunization, all groups had titers that exceeded this level following boost. The antibody levels persisted above this level for the remainder of the study. The titers were significantly higher in the ID group compared to the IM groups for up to 2 weeks following boost, but were similar thereafter. The GLA group did not show higher HAI titers compared to the other groups, thus indicating that the mRNA/LNP formulation itself was sufficiently immunogenic. The third immunization in the GLA group resulted in a transient increase in HAI titers, which returned to similar levels as the other groups 5 weeks later.”
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.
References
25.
TrombettaCMPeriniDMatherSTempertonNMontomoliE. Overview of serological techniques for influenza vaccine evaluation: past, present and future. Vaccines (Basel) (2014) 2:707–34. 10.3390/vaccines2040707
44.
LiangFLindgrenGLinAThompsonEAOlsSet al. Efficient targeting and activation of antigen presenting cells in vivo after modified mRNA vaccine administration in rhesus macaques. Mol Ther. (2017) 25:2635–47. 10.1016/j.ymthe.2017.08.006
Summary
Keywords
mRNA vaccine, adaptive immune responses, non-human primates, influenza, T follicular helper cells, germinal centers
Citation
Lindgren G, Ols S, Liang F, Thompson EA, Lin A, Hellgren F, Bahl K, John S, Yuzhakov O, Hassett KJ, Brito LA, Salter H, Ciaramella G and Loré K (2019) Corrigendum: Induction of Robust B Cell Responses After Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells. Front. Immunol. 10:614. doi: 10.3389/fimmu.2019.00614
Received
21 February 2019
Accepted
07 March 2019
Published
02 April 2019
Approved by
Frontiers in Immunology Editorial Office, Frontiers Media SA, Switzerland
Volume
10 - 2019
Updates
Copyright
© 2019 Lindgren, Ols, Liang, Thompson, Lin, Hellgren, Bahl, John, Yuzhakov, Hassett, Brito, Salter, Ciaramella and Loré.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Karin Loré karin.lore@ki.se
This article was submitted to Vaccines and Molecular Therapeutics, a section of the journal Frontiers in Immunology
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.