CORRECTION article

Front. Immunol., 28 January 2021

Sec. Molecular Innate Immunity

Volume 12 - 2021 | https://doi.org/10.3389/fimmu.2021.649442

Corrigendum: Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways

  • 1. Institute of Organic Chemistry, Department of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria

  • 2. Research Group Innate Immunity, Research Center Borstel—Leibniz Lung Center, Airway Research Center North (ARCN), German Center for Lung Disease (DZL), Borstel, Germany

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In the original article “Muzio, M., Ni, J., Feng, P., and Dixit, V.M. Science (1997) 278(5343):1612–1615” was not cited in the article.

The citation has now been inserted as reference “51” in section Lipopolysaccharide Detection by the Innate Immune System, subsection TLR4-Mediated Signaling Pathways, paragraph two, and should read:

“MyD88 is a 296 aa adaptor protein containing two major domains: a C-terminal TIR domain which associates with other TIR domain-containing proteins and a N-terminal death domain (DD) which mediates the interaction with the IRAK (IL-1R associated kinase) family kinases (49–51). Whereas recruitment to TLR4 is facilitated by homotypic TIR domain interactions and requires the bridging adaptor MAL (52, 53), DDs are used to engage members of the IRAK family to the complex. The whole complex comprises of 14-16 MyD88 and IRAK1, -2, and -4 molecules and has been termed the myddosome (54).”

All reference numbers have been updated accordingly.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Summary

Keywords

lipid A, inflammation, chemical structure, innate immunity, molecular recognition, TLR4/MD-2, inflammasome, aminoarabinose

Citation

Zamyatina A and Heine H (2021) Corrigendum: Lipopolysaccharide Recognition in the Crossroads of TLR4 and Caspase-4/11 Mediated Inflammatory Pathways. Front. Immunol. 12:649442. doi: 10.3389/fimmu.2021.649442

Received

04 January 2021

Accepted

05 January 2021

Published

28 January 2021

Approved by

Frontiers Editorial Office, Frontiers Media SA, Switzerland

Volume

12 - 2021

Updates

Copyright

*Correspondence: Alla Zamyatina,

This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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