SYSTEMATIC REVIEW article

Front. Immunol., 16 August 2023

Sec. Multiple Sclerosis and Neuroimmunology

Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1193835

The effectiveness of shockwave therapy on patellar tendinopathy, Achilles tendinopathy, and plantar fasciitis: a systematic review and meta-analysis

  • 1. School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China

  • 2. Engineering Research Centre of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China

  • 3. Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China

Abstract

Background:

Tendinopathy is a growing global concern affecting many people, like athletes, workers, and the elderly. Despite its commonality among the sporting population, there is no practical clinical guideline for patellar tendinopathy (PT). Furthermore, there is conflicting evidence between clinical guidelines on shockwave therapy’s application and clinical utility for Achilles tendinopathy (AT) and plantar fasciitis (PF). Thus, our aim of this study is to evaluate the evidence for shockwave therapy; to provide a Grading of Recommendation, Assessment, Development and Evaluation (GRADE) level of the evidence and effectiveness of shockwave therapy for patellar tendinopathy, Achilles tendinopathy, and Plantar fasciitis.

Method:

Medical Literature Analysis and Retrieval System Online (Medline), Embase, The Cumulative Index to Nursing and Allied Health Literature (CINAHL), Physiotherapy Evidence Database (PEDro) and China National Knowledge Infrastructure database (CNKI) were searched to find relevant studies published before December 14th, 2022.

Results:

Our study showed that for PT in the short term, extracorporeal shockwave therapy (ESWT) or ESWT + eccentric exercise (EE) has a negligible effect on pain and function compared to a placebo or placebo + EE. On the contrary, ESWT significantly affects pain compared to conservative treatment (CT). For AT, ESWT has a small inconclusive effect on pain and function in the short term compared to EE. On the other hand, a placebo outperformed ESWT in improving function for AT but not pain outcomes. PF showed that ESWT significantly affects short- and long-term pain and function. When ESWT was compared to other interventions such as low laser therapy (LLLT), corticosteroid injection (CSI), or CT, there was a small inconclusive effect on pain and function in the short term.

Conclusion:

There is low-moderate evidence that ESWT has a negligible effect on pain and function for PT and AT. However, high-quality evidence suggests ESWT has a large effect on pain and function for PF.

Systematic review registration:

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023396835, identifier CRD42023396835.

1 Introduction

Tendinopathy is a growing global concern affecting a broad spectrum of people, like athletes, workers, and the elderly (). Surprisingly, there have been no studies to quantify the total burden of disease that tendinopathy can place on society, governments, and patients (). Lower limb Tendinopathy (LLT) frequently occurs at the lateral to posterior hip as gluteal tendinopathy, anterior knee as patellar tendinopathy, posteriorly medial ankle as Achilles tendinopathy, or posterior tibialis tendinopathy (, ). According to Hopkins et al. (), characteristics such as sex, age, occupation, physical activity level, and type of sports involved are risk factors for developing LLT. LLT increases with age and affects females more than males (). The higher rates in females are hypothesized to be due to the metabolic changes that occur during menopause. However, studies have shown that patellar tendinopathy affects athletic men more than athletic women (, ).

Patellar tendinopathy (PT) is persistent patellar tendon pain and loss of function related to mechanical loading due to high-impact loading on the knee extensor during physical activities (, ). King et al. () depicted a prevalence of PT in the athletic population to account for 14.2% of the overall sports injury. Citing sports that demand a high load on the knee extensor complex had a high prevalence, while sports with a low impact on the knee extensor complex had a low prevalence. In elite male soccer/football, approximately 2.4% of players every season get affected by PT, with 61% of these athletes missing up to one week of competition or training session (). Evidence suggests that Ultrasonographic abnormality is three times as common as clinical symptoms; hence clinical diagnosis is the preferred option for diagnosing PT ().

Additionally, Achilles tendinopathy (AT) is persistent Achilles tendon pain and loss of function related to mechanical loading due to excessive loading on the plantar flexor complex (, 10). AT can occur at the midportion of the Achilles tendon or the insertion of the Achilles tendon. AT can affect both the sporting population and the general population. De Jonge et al. (11) showed that the AT incidence rate is 2.53 per 1000 persons in the adult population. Of this, 35% of the cases are related to sporting activities. Although there is a higher cumulative incidence of AT before age 45, the lifetime cumulative incidence of AT is 52% for former endurance runners (12).

Moreover, Plantar fasciitis (PF) is posterior foot pain or heel pain that occurs along the calcaneus to the digits of the foot (13). The prevalence of PF in the general population is approximately 3.6% to 7%; however, PF accounts for 8% of all running-related injuries (14–16). A high body mass index and limited dorsiflexion are the most common risk factors for developing PF (17). As per the conditions mentioned above, PF is also a clinical diagnosis. The first-step pain and pain during weight-bearing activities are the main symptoms (18, 19).

Despite its commonality among the sporting population, there is no practical clinical guideline for patellar tendinopathy. The last systematic review looking at the effectiveness of shockwave therapy for PT was published more than five years ago, and therefore, new trials could have been done in the interim (20, 21). The clinical uncertainty surrounding the level of evidence for shockwave therapy use for PT persists. Furthermore, there needs to be more clarity between clinical guidelines for Achilles tendinopathy, with one clinical guideline that does not recommend shockwave therapy. In contrast, the other clinical guideline does recommend it as an adjunct modality (10, 22). This uncertainty between clinical guidelines could lead to ambiguity among clinicians on whether or not to use shockwave therapy in their clinical practice. Additionally, the latest review that looked at the effectiveness of shockwave therapy for AT used a fixed effect model in their analysis, which does not account for variations in participant characteristics between studies, the distribution of effect sizes, and differences in treatment protocols, dosages, and procedures (23). A similar situation exists in PF clinical guidelines where one guideline recommends it as a secondary approach if standard care fails while the other does not. Apart from this, an updated systematic review is needed due to the previous review investigating the effectiveness of shockwave therapy for PF being ≥ five years (24, 25).

This systematic review aimed to evaluate the evidence for shockwave therapy; to provide a Grading of Recommendations, Assessment, Development and Evaluations (GRADE) level of the evidence and effectiveness of shockwave therapy for patellar tendinopathy, Achilles tendinopathy, and Plantar fasciitis.

2 Methods

2.1 Search strategy and eligibility criteria

This systematic review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement (26). This study did not require ethical approval since the data was obtained exclusively from previously published sources.

An electronic literature search was conducted via four English language databases and one Chinese database; these search databases are as follows: Medical Literature Analysis and Retrieval System Online (Medline) was searched on December 14th, 2022, Embase on December 15th, 2022, The Cumulative Index to Nursing and Allied Health Literature (CINAHL) on December 18th, 2022, Physiotherapy Evidence Database (PEDro) on December 17th, 2022 and China National Knowledge Infrastructure database (CNKI) on December 18th, 2022. The detailed search strategy is presented in the Supplementary Material. The following Boolean operators were used in Medline, Embase, and CINAHL, databases to search for patellar tendinopathy; (patellar tendinopathy) OR (jumper’s knee) OR (patellar tendinosis) OR (patellar tendinitis) OR (patellar tendonitis) AND (shockwave) OR (shockwave therapy) OR (radial shockwave) OR (focused shockwave) OR (extracorporeal shockwave) OR (ESWT). The Boolean operators for Achilles tendinopathy; (Achilles tendinopathy) OR (Mid-portion Achilles tendinopathy) OR (Insertional Achilles tendinopathy) AND (shockwave) OR (shockwave therapy) OR (radial shockwave) OR (focused shockwave) OR (extracorporeal shockwave) OR (ESWT). The Boolean operators for Plantar fasciitis (plantar fasciitis) OR (plantar fasciopathy) OR (heel pain) AND (shockwave) OR (shockwave therapy) OR (radial shockwave) OR (focused shockwave) OR (extracorporeal shockwave) OR (ESWT). Previous systematic reviews were screened for articles and checked citations through google scholar.

The inclusion criteria were: P; People between the ages of 18 or 70 with a clinical diagnosis of patellar tendinopathy, Achilles tendinopathy, and plantar fasciitis of any duration and severity with or without radiological confirmation. I; Studies that included shockwave therapy: radial shockwave therapy or focused shockwave therapy as the mode of treatment. C; Studies compared shockwave therapy to placebo, eccentric exercise, or other interventions. O; Studies that had pain and function as outcome measures. S; completed randomized controlled trials were included in this study. Studies were excluded from the analysis: non-randomized trials, case reports, observational studies, literature reviews, case series, and public conference abstracts. RCTs protocols, uncompleted and unable to access full-text of RCTs were excluded. Studies with missing information regarding the outcome data and the corresponding author who did not respond when contacted for missing data were included in the systematic review for qualitative analysis but were excluded from the quantitative analysis.

2.2 Outcome measure

Primary outcome: One primary outcome was pain intensity, measured by a self-reporting tool such as a visual analog scale (VAS), numeric rating scale (NRS), or an equivalent pain perception scale. The other primary outcome was function measured by a self-reporting tool such as the Victorian Institute of sports assessment-patellar (VISA-P), Victorian Institute of sports assessment-Achilles (VISA-A), Foot Function Index (FFI), American Orthopaedic Foot and Ankle Society (AOFAS) and Roles and Maudsley Score (RMS). The timing of the follow-up grouped outcomes: short-term (≤3 months), mid-term (>3 months- ≤ 6 months), and long-term (≥12 months).

2.3 Selection of studies and assessment of quality

Two independent reviewers screened all titles and abstracts identified by the search strategy to pinpoint potentially eligible studies. Then, they independently assessed all full texts, and the RCTs that met the inclusion criteria were included in the systematic review. In a disagreement, the two independent reviewers discussed trying to come to a resolution. If no resolution was found, a third reviewer assessed the situation and decided whether or not the article is included or excluded. A commercial reference management software was used for retrieving studies, screening, eliminating duplicates, and managing references.

The internal validity of the included studies was assessed using the Cochrane Collaboration tool for assessing the risk of bias in randomized trials (27). Five domains from this tool were evaluated: Bias arising from the randomization process, bias due to deviation from intended interventions, bias due to missing outcome data, bias in the measurement of the outcome, and bias in the selection of the reported result. The study was classified as having a ‘low,’ ‘high,’ or ‘unclear’ risk of bias based on the two independent reviewer’s judgment of the subcomponents of the Cochrane risk of bias tool. Discrepancies were resolved through discussions. If no resolution was found, a third reviewer assessed the situation and decide on the risk of bias. The Grading of Recommendation Assessment, Development, and Evaluation (GRADE) tool was used to assess the certainty of the evidence (28). This tool comprises five main domains: risk of bias, inconsistency of results, indirectness of evidence, imprecision, and publication bias, assessed independently by two reviewers and resolved through discussion. If no resolution was found, a third reviewer assessed the situation.

2.4 Data collection and analysis

Two independent reviewers extracted the data from included studies that characterize the similarities and differences among participants: sample size, sex, age range, country, and type of population. Furthermore, shockwave therapy intervention data were extracted, such as intensity, frequency of treatment, and total duration of the intervention period. The data was compelled and then stored on commercial Microsoft office software.

The meta-analysis was conducted using Revman 5.4 software. Post-treatment means and SDs were extracted from continuous data, while dichotomous data, such as successful outcomes, were extracted. Where there were missing data, the corresponding author was contacted regarding the missing data. If requested data was not provided, attempts to calculate the SDs from CIs, SEs, or p- values were done according to the Cochrane Handbook for systematic reviews of interventions (29). For reporting continuous data, a standardized mean difference (SMD) was calculated, irrespective of whether the outcomes were similar or different. However, only outcomes of a similar construct, for example, pain intensity: VAS and NRS, were combined. The Effect sizes were 0.20-0.49 as small, 0.50-0.79 as medium, and 0.80 or above as large (30). For reporting dichotomous outcomes, odd ratios were used to represent intervention success, where a positive intervention effect >1. The random effects model with a 95% confidence interval was used, assuming variations in participant characteristics between studies, the distribution of effect sizes, and differences in treatment protocols, dosages, and procedures. An I2 test measured heterogeneity; an I2 value of 25% was low, 50% was moderate, and 75% was high heterogeneity (31). Suppose an analysis includes ten or more studies, and there is statistical significance for heterogeneity with a high percent of I2 (>75%). In that case, the prediction interval was examined to determine the estimated effect size distribution. After determining the seriousness of the heterogeneity, further subgroup analysis of the outliers may be performed if warranted. Additionally, if ten or more studies are included in an analysis, a funnel plot was be created to test for publication bias.

3 Results

3.1 Result of search

A total of 6348 articles were identified during the initial search of the above databases and through checking citations on google scholar. After the vigorous screening, sixty-three studies were eligible for this systematic review. Figure 1 depicts the flow of articles through the search, screening, and inclusion processes.

Figure 1

3.2 Characteristics of studies

Sixty-three studies were included in this review; ten studies on patellar tendinopathy, thirteen studies on Achilles tendinopathy, and forty articles on plantar fasciitis. Details about the characteristics of the included studies are shown in Table 1.

Table 1

StudyDesignParticipantsInterventionOutcome measures
Taunton et al. (2003) (32)RCTn =20
age range:23-52;
Gender = 10 M, 10 F
Population: athlete (not specified)
Exp = ESWT
 2000imp level 4 (0.17 mJ/mm2) x 3-5TS/3wk – 5wk
Con = placebo
• VISA-P
• Follow up = 5, 12 wk
Zwerver et al. (2011) (33)RCTn = 62
Age (yr) = 24.9 (SD 4.9)
Gender = 41 M, 21 F
Population: basketball, handball, netball
Exp = ESWT
 2000 imp at 4 Hz x 3TS/3wk
Con = placebo
• VISA-P
• VAS
• Follow up = 1, 12, 22wk
Zhang et al. (2020) (34)RCTn = 34
Age (yr) = 22.2 (SD 3.8)
Gender = 34 M
Population: basketball, volleyball
Exp = ESWT
 1500imp at 4 Hz
Con = placebo
• VISA-P
• VAS
• Follow up = immediate after treatment
ThØger et al. (2021) (35)RCTn = 36
Age (yr) = 31.6 (SD10.4)
Gender = 20M, 16F
Population: general population
Exp = ESWT
1500-3000imp x 3TS/4wk
Con = placebo
• NRS
• Follow up = 2, 4, 12wk
Thijs et al. (2017) (36)RCTn = 52
Age (yr) = 28.6 (SD6.7)
Gender = 38M, 14F
Population: physically active
Exp = fESWT+ EE
1000imp at 4 Hz x 3TS/3wk
Con = placebo+ EE
• VISA-P
• NRS
• Follow up = 6, 12, 24wk
Lee et al. (2017) (37)RCTn = 34
Gender: 34M
Population: volleyball, basketball, handball
Exp = fESWT + EE
 1500imp at 4 Hz x 6TS/6wk
 3x12 twice per day (5kg) x 12wk
Con = placebo + EE
• VISA-P
• VAS
• Follow up = 12wk
Cheng et al. (2019) (38)RCTn= 51
Gender: 25M, 26F
Population: judo, volleyball, rowing athlete, basketball, wrestling, weigth-lifting, track and field
Exp = ESWT
 2000imp at 9-12 Hz x 16TS/16wk
Con = acu + ultrasonic wave therapy
• VAS
• Follow up = 16wk
Wang et al. (2007) (39)RCTn= 50
Gender: 27M, 23F
Population: basketball, jogging, handball, weight lifting, wrestling
Exp = ESWT
1500imp
Con = conservative treatment
• VISA-P
• VAS
• Follow up = 4, 12, 24, 48wk
Van der Worp et al. (2014) (40)RCTn= 43
Age (yr) =31.1 (SD10.7)
Gender: 32M, 11F
Population: sport population
Exp = fESWT + EE
 2000imp at 4 Hz x 3TS/3wk
Con = rESWT + EE
 2000imp at 8Hz x 3TS/3wk
• VISA-P
• VAS
• Follow up = 7, 14wk
Vetrano et al. (2013) (41)RCTn= 46
Gender: 37M, 9F
Population: sport population
Exp= ESWT + HE
 2000imp x 3TS/1wk
Con = PRP + HE
• VISA-
• VAS
• Follow up = 8, 24, 48wk
Abdelkader et al. (2021) (42)RCTn= 50
Gender: 22M, 28F
Population: general population
Exp= ESWT + EE
 2000imp at 8 Hz x 4TS/4wk
 3x15 twice per day x 7d/wk/4wk
Con = placebo + EE
• VISA-A
• VAS
• Follow up = 4, 28, 64wk
Benli et al. (2022) (43)RCTn= 60
Age (yr) = 37.3(SD12.2)
gender: 23M, 40F
Population: sporting population
Exp = ESWT
 1500imp at 12Hz
Con= EE
 3x15 twice per day (5kg which increased 1 kg every two weeks)
• VISA-A
• VAS
• Follow up = 12, 96wk
Gatz et al. (2021) (44)RCTn=66
gender: 40M, 26F
Population: general population
Exp= pESWT
2000imp at 5Hz x 4TS/6wk
Exp = lESWT
 2000imp at 5Hz x 4TS/6wk
Con= placebo
• VISA-A
• AOFAS
• Follow up = 6, 24wk
Vahdatpour et al. (2018) (45)RCTn=43
age range: 18-70
gender: 8M, 35F
Population: general population
Exp= fESWT
 1500imp at 2.3Hz x 4TS/4wk
Con= placebo
• AOFAS
• VAS
• Follow up = 4, 16wk
Lynen et al. (2016) (46)RCTn= 59
gender: 28M, 31F
Population: general population
Exp = ESWT
 1500imp at 4Hz x 3TS/3wk
Con = HA
• VISA-A
• VAS
• Follow up = 4, 12, 24wk
Notarnicola et al. (2013) (47)RCTn=60
Population: general population
Exp= ESWT
 1600imp x 3TS/2wk
Con= CHELT
• VAS
• AOFAS
• RMS
• Follow up = 8, 24wk
Rasmussen et al. (2008) (48)RCTn= 48
age range: 18-60
Population: general population
Exp= ESWT
 2000imp at 50Hz x 4TS/4wk
Con= placebo
• AOFAS
• VAS
• Follow up = 4, 8, 12wk
Rompe et al. (2006) (49)RCTn= 50
age range: 18-70
Population: general population
Exp= ESWT
 2000imp at 8Hz x 3TS/3wk
Con= EE
 3x15 twice per week (5kg) x 7d/wk/12wk
Con = WS
• VISA-A
• NRS
• Follow up = 6, 16wk
Rompe et al. (2008) (50)RCTn= 50
gender: 20M, 30F
Population: general population
Exp = ESWT
 2000imp at 8Hz x 3TS/3wk
Con = EE
 3x15 twice per week (5kg) x 7d/wk/12wk
• VISA-A
• NRS
• Follow up = 6, 16wk
Rompe et al. (2009) (51)RCTn= 68
gender: 30M, 38F
Population: general population
Exp= ESWT + EE
 2000imp at 8Hz x 3TS/3wk
 3x15 twice per week (5kg) x 7d/wk/12wk
Con= EE
• VISA-A
• NRS
• Follow up = 6, 16wk
Costa et al. (2005) (52)RCTn= 49
gender: 21M, 28F
Population: general population
Exp= ESWT
 1500imp x 3TS/12wk
Con= placebo
• VAS
• Follow up = 12, 48wk
Mansur et al. (2021) (53)RCTn= 119
age range: 18-76
gender: 61M, 58F
Population: general population
Exp= rESWT + EE
 2000-3000imp at 7-10Hz x 3TS/4wk
 3x15 twice per week (5kg) x 7d/wk/12wk
Con= EE
• VISA-A
• Follow up = 2, 4, 6, 12, 24wk
Pinitkwamdee et al. (2020) (54)RCTn= 31
age range= 18-70
gender: 7M, 24F
Population: general population
Exp= ESWT
 2000imp at 8-12Hz x 4TS/4wk
Con = placebo
• VAS
• Follow up = 2, 3, 4, 6, 12, 24wk
Alpturker et al. (2020) (55)RCTn=40
Age (yr) = 37.78(SD9.86)
Gender: 20M, 20F
Population: general population
Exp= ESWT
 2000imp at 10Hz
Con= LLLT
• AOFAS
• VAS
• RMS
• Follow up= 4wk
Asheghan et al. (2019) (56)RCTn= 62
age range: 18-75
gender: 20M, 39F
Population: general population
Exp= ESWT
 2000imp at 10Hz x 3TS/3wk
Con= prolotherapy
• VAS
• Follow up= 6, 12wk
Bagcier et al. (2020) (57)RCTn= 40
Age (yr) = 43.6 (SD 11.8)
Gender: 11M, 29F
Population: general population
Exp= ESWT
 2500imp at 12-15Hz x 3TS/3wk
Con= ESWT + DN
• VAS
• Follow up= 4wk
Bahar et al. (2020) (58)RCTn=45
Age (yr) = 43.6 (SD11.8)
Population: general population
Exp = ESWT+ KT
 3000imp at 11Hz x 5TS/5wk
Con= ESWT + Placebo KT
Con = ESWT
• VAS
• Follow up= 4wk
Buchbinder et al. (2002) (59)RCTn= 166
age range: 18-70
gender: 68M, 93F
Population: general population
Exp= ESWT
 2000- 2500imp
Con= placebo
• VAS
• Follow up= 6, 12wk
Caner et al. (2021) (60)RCTn= 22
gender: 6M, 16F
Population: general population
Exp= ESWT
 500imp at 10Hz x 3TS/3wk
Con= placebo
• VAS
• Follow up= 4, 8wk
Chew et al. (2013) (61)RCTn=54
gender: 29M, 25F
Population: general population
Exp= ESWT
 2000imp x 2TS/2wk
Con= ACP
Con= CT
• VAS
• AOFAS
• Follow up= 4, 12, 24wk
Cinar et al. (2018) (62)RCTn=66
gender: 10M, 56F
Population: general population
Exp= ESWT
 2000imp x 3TS/3wk
Con= LLLT
Con= IEP
• NRS
• FFI
• Follow up= 3, 12wk
Cinar et al. (2020) (63)RCTn= 44
gender: 4M, 40F
Population: general population
Exp= ESWT
 2000imp x 3TS/3wk
Con= IEP
• AOFAS
• Follow up= 3, 12wk
Damla et al. (2019) (64)RCTn=40
age range: 18-65
Population: general population
Exp= ESWT
 2000imp at 10Hz x 3TS/3wk
Con= LLLT
• VAS
• FFI
• Follow up= 4wk
Dingli et al. (2020) (65)RCTn= 96
gender: 29M, 68F
Population: general population
Exp= ESWT
 2000imp x 3TS/3wk
Con= CI
• VAS
• FFI
• Follow up = 12, 24wk
Eslamian et al. (2016) (66)RCTn= 40
age range: 18-65
gender: 7M, 33F
Population: general population
Exp= ESWT
 2000imp x 5TS/2wk
Con= CI
• VAS
• FFI
• Follow up = 4, 8wk
Gerdesmeyer et al. (2008) (67)RCTn= 243
Population: general population
Exp= rESWT
2000imp x 3TS/6wk
Con= placebo
• VAS
• Follow up = 12, 48wk
Gollwitzer et al. (2007) (68)RCTn= 40
gender: 15M, 25F
Population: general population
Exp= fESWT
 2000imp x 3TS/3wk
Con= placebo
• VAS
• RMS
• Follow up = 12wk
Gollwitzer et al. (2015) (69)RCTn= 246
Population: general population
Exp= fESWT
 2000imp x 3TS/3wk
Con= placebo
• VAS
• RMS
• Follow up= 12wk
Haake et al. (2003) (70)RCTn= 271
gender: 67M, F204
Population: general population
Exp= ESWT
 4000imp x 3TS/6wk
Con= placebo
• VAS
• RMS
• Follow up = 6, 12, 48wk
Ibrahim et al. (2010) (71)RCTn= 50
gender: 18M, 32F
Population: general population
Exp= rESWT
 2000imp x 2TS/2wk
Con= placebo
• VAS
• RMS
• Follow up = 4, 12, 24wk
Ibrahim et al. (2016) (72)RCTn= 50
gender: 18M, 32F
Population: general population
Exp= rESWT
 2000imp x 2TS/2wk
Con= placebo
• VAS
• RMS
• Follow up = 4, 12, 24, 52wk
Kesikburun et al. (2022) (73)RCTn= 27
gender: 7M, 20F
Population: general population
Exp= ESWT
 1800-2000imp at 4-6Hz x 3TS/6wk
Con= prolotherapy
• VAS
• RMS
• FFI
• Follow up = 6, 12wk
Kudo et al. (2006) (74)RCTn= 114
gender: 37M, 73F
Population: general population
Exp= ESWT
 3800imp x 3wk
Con= placebo
• VAS
• RMS
• AOFAS
• Follow up = 6w, 12w
Lai et al. (2018) (75)RCTn=97
gender: 43M, 54F
Population: general population
Exp= ESWT
 1500imp x2TS/2wk
Con= CI
• VAS
• Follow up = 4, 12wk
Malay et al. (2006) (76)RCTn= 172
gender: 57M, 115F
Population: general population
Exp= ESWT
 3800imp
Con= placebo
• VAS
• Follow up = 4, 8, 12wk
Mardani et al. (2015) (77)RCTn= 84
gender: 11M, 57F
Population: general population
Exp= ESWT
 2000imp x 3TS/3wk
Con= CI
• VAS
• Follow up = 3, 6, 12wk
Meriç et al. (2018) (78)RCTn= 158
gender: 79M, 79F
Population: general population
Exp= ESWT
 2000imp at 6Hz x 3TS/3wk
Con= prolotherapy
Con= PRP
Con = CI
• VAS
• FFI
• Follow up = 4, 12, 24, 48, 96, 144wk
Ordahan et al. (2017) (79)RCTn=70
gender: 16M, 54F
Population: general population
Exp= ESWT
 2500imp at 12-15Hz x 5TS/5wk
Con= KT
• VAS
• Follow up = 5wk
Porter et al. (2005) (80)RCTn= 125
gender: 42M, 83F
Population: general population
Exp = ESWT
 1000imp x 3TS/3wk
Con= CI
• VAS
• Follow up = 4, 8wk
Rahbar et al. (2018) (81)RCTn= 72
gender: 18M, 54F
Population: general population
Exp= ESWT
 2000imp at 10Hz x 3TS/3wk
Con= DN
• VAS
• FFI
• Follow up= 4, 8wk
Razzano et al. (2017) (82)RCTn=104
gender= 53M, 51F
Population: general population
Exp= ESWT
 2000imp x 3TS/3wk
Con= NIN
• VAS
• FFI
• Follow up = 4, 12wk
Roca et al. (2016) (83)RCTn=72
gender: 19M, 53F
Population: general population
Exp= ESWT
 3000imp at 4Hz
Con= BTA
• VAS
• RMS
• Follow up = 4, 6wk
Rompe et al. (2003) (84)RCTn= 45
gender: 22M, 23F
Population: general population
Exp= ESWT
 2100imp at 4Hz x 3TS/3wk
Con= placebo
• VAS
• AOFAS
• Follow up = 24, 48wk
Rompe et al. (2005) (85)RCTn=86
gender: 35M, 51F
Population: general population
Exp= ESWT
 2000imp x3TS/3wk
Con= ESWT + LA
• NRS
• AOFAS
• Follow up= 3, 12, 48wk
Rompe et al. (2010) (86)RCTn= 102
gender: 36M, 66F
Population: general population
Exp= rESWT
 2000imp at 8Hz x 3TS/3wk
Con= PFSS
• FFI
• Follow up= 8, 16, 60wk
Rompe et al. (2015) (87)RCTn= 152
gender: 71M, 81F
Population: general population
Exp= ESWT + PFSS
 2000imp at 8Hz x3TS/3wk
Con= ESWT
• FFI
• Follow up= 8, 16, 96wk
Sibel et al. (2019) (88)RCTn=83
gender: 15M, 68F
Population: general population
Exp= ESWT
 2000imp at 12Hz x 3TS/3wk
Con= CFO
• VAS
• FFI
• Follow up= 4, 12, 24, 48wk
Speed et al. (2003) (89)RCTn= 88
gender: 37M, 51F
Population: general population
Exp= ESWT
 1500imp x 3TS/12wk
Con=placebo
• VAS
• Follow up= 4, 12wk
Tezel et al. (2020) (90)RCTn= 78
gender: 14M, 65F
Population: general population
Exp= ESWT
 2000imp at 6Hz x 6TS/6wk
Con= KT
• VAS
• FFI
• Follow up= 6wk
Theodore et al. (2004) (91)RCTn=150
gender: 41M, 109F
Population: general population
Exp= ESWT
 1300imp x 3TS/3wk
Con= placebo
• RMS
• VAS
• AOFAS
• Follow up= 6, 12, 24, 48wk
Timurtaş et al. (2022) (92)RCTn= 47
gender: 9M, 38F
Population: general population
Exp= ESWT
 1000imp x 3TS/3wk
Con= LLLT
• FFI
• VAS
• Follow up= 3wk
Ulusoy et al. (2017) (93)RCTn=60
gender: 12M, 49F
Population: general population
Exp= ESWT
 2000imp x 3TS/3wk
Con= LLLT
Con= US
• VAS
• AOFAS
• RMS
• Follow up=4wk
Yucel et al. (2010) (94)RCTn= 60
gender: 18M, 42F
Population: general population
Exp= ESWT
 3000imp
Con=CI
• VAS
• Follow up= 12wk

Summary of included studies.

Exp, experimental group; Con, control group; ESWT, Extracorporeal shockwave therapy; VISA-P, Victorian Institute of Sports Assessment- Patellar; wk, Week; d/wk, days per week; VAS, Visual Analog Scale S; NRS, Numeric rating scale; fESWT, Focus Extracorporeal shockwave therapy; EE, Eccentric exercise; rESWT, Radial Extracorporeal shockwave therapy; PRP, Platelet-Rich Plasma injection; CT, Conservative treatment; lESWT, Line-focused Extracorporeal shockwave therapy; pESWT, Point-focused Extracorporeal shockwave therapy; AOFAS, American Orthopaedic Foot and Ankle Society; VISA-A, Victorian Institute of Sports Assessment–Achilles; HA, Hyaluronan injections; CHELT, Cold air and High Energy Laser Therapy; RMS, Roles and Maudsley Score; WS, Wait and See; LLLT, Low-level laser therapy; FFI, Foot Function Index; DN, Dye-Needling; KT, Kinesiology Tape; ACP, Autologous Conditioned Plasma; IEP, Insole and exercise program; CI, Corticosteroid Injection; NIN, Noninvasive Interactive Neurostimulation; PFSS, Plantar Fascia-Specific Stretching; CFO, Custom Foot Orthotics; imp, impulse; TS, treatment session; n, sample size; LA, local anesthesia; BTA, botulinum toxin type A; acu, acupuncture.

3.3 Risk of bias and certainty of the evidence assessment

Of the sixty-three studies included in this systematic review, the randomization process was classified as low risk of bias in fifty-five studies, high risk of bias in seven, and with some concerns of bias in one study. All Sixty-three studies had a low risk of bias for deviation from the intended intervention. Missing outcome data had twenty-four studies at low risk and thirty-nine studies at high risk. The risk of bias due to measurement was classified as low in forty-two studies and high in twenty-one studies. The risk of bias in the selection of the reported result was forty-seven articles low, three articles high, and thirteen articles with some concerns of bias. The risk of bias in the included studies is depicted below in Figure 2. The detailed GRADE quality assessment result is shown in Figures 7 to 16 on Supplementary Material.

Figure 2

3.4 Clinical heterogeneity

Nine out of the possible ten studies for patellar tendinopathy were done in the sporting population from varying sports such as basketball, handball, volleyball, football, and track and field. Only one study was done on the general population. In addition, all thirteen included studies looking at Achilles tendinopathy were in the general population. These studies recruited a higher number of males in studies. On the contrary, all forty studies for plantar fasciitis recruited more females than males. Also, the studies were done on the general population.

Four studies compared Extracorporeal Shockwave therapy (ESWT) to placebo only for PT. These studies had very similar shockwave impulses at 1500-3000, the frequency at 4Hz, the treatment session at three weeks, and the duration at 3-5 weeks. The two studies that compared focused ESWT + Eccentric exercise (EE) to placebo + EE showed differences in treatment sessions and durations for shockwave where one study had three treatment sessions over three weeks while the other had six treatment sessions over six weeks; however, they both had similar repetition and set ranges; however different load (intensity). A study compared focused ESWT + EE to radial ESWT + EE, and another study compared radial ESWT against conservative treatment; however, Wang et al. compared ESWT to conservative treatment. The final article for PT compared platelet-rich plasma against ESWT.

Additionally, the six articles that compared ESWT to a placebo for Achilles tendinopathy had vast variations in the treatment session, treatment duration, shockwave impulse, and frequency. Another six studies compared ESWT to EE with identical exercise prescriptions but differences in ESWT protocol. The final two trials compared ESWT to Hyaluronan injection, Cold air, and High Energy Laser Therapy.

Also, thirteen studies compared ESWT to placebo for plantar fasciitis with varying discrepancies in ESWT procedure and protocol. The seven studies that compared ESWT to Corticosteroid injection (CSI) also had variations in ESWT procedure and protocol. In addition, five articles compared ESWT to low laser therapy (LLLT), and three compared ESWT to prolotherapy with a difference in the protocol for the intervention and control groups. The remaining twelve studies that compared ESWT to conservative treatment CT depicted similar inconsistencies. Important to note that the follow-up timepoint varied from immediate (directly after the intervention) to 144 weeks after the intervention.

3.5 Evidence of effect on patellar tendinopathy

ESWT VS Placebo: based on the analysis of three studies comparing ESWT to placebo, it can be concluded with very low certainty of evidence that ESWT intervention has no superiority over placebo for reducing pain in the short-term. ESWT +EE VS Placebo+ EE: from the analysis of three studies comparing ESWT + EE and placebo + EE, it can be concluded with moderate certainty of evidence that ESWT intervention had a negligible effect in reducing pain but crosses the line of no effect; thus, no conclusive superiority over placebo. Additionally, ESWT had no superiority over placebo for improving function in the short term. ESWT VS Conservative treatment: based on the analysis of two studies comparing ESWT to conservative treatment, it can be concluded with low certainty of evidence that ESWT has a large treatment effect for reducing pain in the short term. A forest plot of the results is presented in Figures 3A, B.

Figure 3

3.6 Evidence of effect on Achilles tendinopathy

ESWT VS Placebo: From the analysis of four studies comparing ESWT and placebo, it can be concluded with low certainty of evidence that ESWT intervention had a large effect in improving function and reducing pain in the short term but crosses the line of no effect; thus, no conclusive superiority over placebo. ESWT VS EE: Based on the analysis of five studies comparing ESWT to EE, it can be concluded with low certainty of evidence that ESWT intervention had a small effect on reducing pain but crosses the line of no effect; thus, no conclusive superiority over EE. Additionally, ESWT had no superiority over EE for improving function in the short term. A forest plot of the results is presented in Figures 4A, B.

Figure 4

3.7 Evidence of effect on plantar fasciitis

ESWT VS Placebo: from the analysis of thirteen studies comparing ESWT and placebo, it can be concluded with moderate-high certainty of evidence that ESWT has a large treatment effect for improving function in the short term. Additionally, ESWT has a large treatment effect on reducing pain in the short-term, mid-term, and long-term. ESWT VS CSI: based on the analysis of six studies comparing ESWT to CSI, it can be concluded with very low certainty of evidence that ESWT had a small effect on reducing pain in the short term but crosses the line of no effect thus no conclusive superiority over CSI. ESWT VS LLLT: from the analysis of four studies comparing ESWT and LLLT, it can be concluded with low - moderate certainty of evidence that ESWT intervention had a negligible effect on improving function but crosses the line of no effect; thus, no conclusive superiority over LLLT. Additionally, ESWT had no superiority over LLLT in reducing pain in the short term. ESWT VS Prolotherapy: Based on the analysis of three studies comparing ESWT to Prolotherapy, it can be concluded with low certainty of evidence that ESWT intervention had a small effect on reducing pain in the short term but crosses the line of no effect; thus, no conclusive superiority over prolotherapy. ESWT VS CT: from the analysis of five studies comparing ESWT and CT, it can be concluded with low certainty of evidence that ESWT intervention has no superior over CT for reducing pain in the short term. A forest plot of the results is presented in Figures 5, 6.

Figure 5

Figure 6

3.8 Publication bias

No publication bias analysis was done because fewer than ten studies were in an analysis group.

4 Discussion

4.1 Summary of effects

In this systematic review, we investigated the effectiveness of ESWT on pain and function for patellar tendinopathy, Achilles tendinopathy, and plantar fasciitis compared to a placebo, eccentric exercise, and other interventions. Our study found low to moderate-quality evidence that ESWT or ESWT + EE has a negligible effect on pain and function in the short term compared to a placebo or placebo + EE for PT. On the contrary, we found low-quality evidence that ESWT has a large effect on pain in the short term compared to conservative treatment for PT. For AT, our review found low-quality evidence that ESWT may have a small inconclusive effect on pain and function in the short term compared to EE. On the other hand, a placebo outperformed ESWT in improving function for AT but not pain outcomes. The results for PF showed moderate to high-quality evidence that ESWT has a large effect on pain and function in the short-term, mid-term, and long-term. When ESWT was compared to other interventions such as LLLT, CSI, or CT, there was low to moderate-quality evidence that suggested a small inconclusive effect on pain and function in the short term.

Most studies did not report the type of ESWT used and had vast variations in impulses, frequencies, treatment durations, and sessions. This makes it difficult to comment on an adequate protocol. Some studies did report the type of ESWT, which were Focus Extracorporeal Shockwave Therapy (fESWT) and Radial Extracorporeal Shockwave Therapy (rESWT), respectively; for PF, both fESWT and rESWT had a large effect with high-quality evidence. This implies that both fEWST and rESWT will probably give similar results on pain and function outcomes for PF. Most studies for AT and PT did not report the type of ESWT used. However, in the few studies that reported the type of intervention, negligible effects with low to moderate-quality evidence were shown in both interventions. Additionally, our findings suggest that regardless of the participants from a specific sport or general population, ESWT may have negligible effects with low to moderate quality evidence on the pain and function outcome for PT and AT patients. On the contrary, ESWT likely has a large effect, with high-quality evidence on the pain and function outcome for PF patients from a diverse population.

4.2 Summary of previous studies

Due to the lack of clinical practice guidelines for PT, a systematic review of the literature and a GRADE quality assessment of the evidence that outlines the effectiveness of ESWT and ESWT compared to its comparators is imperative to provide clinicians with quality information to make an informed decision about the best available option in managing their patients. Additionally, this review updates the evidence of the previous reviews. Manu et al. (21) conducted a systematic review investigating the effectiveness of ESWT for PT. Their inclusion criteria included both RCTs and non-RCTs, which led to poor methodological studies that may have over or under-estimated the true effect of ESWT for PT. Also, a more recent review by Korakakis et al. (20) had similar shortcomings; hence those reviews likely did not provide a reasonable answer to the effectiveness of ESWT for PT.

Furthermore, ESWT is widely used and recommended by the International Society for Medical Shockwave Treatment (ISMST) (95) for AT; however, prestigious physical therapy practice guideline (22) has recommended against using ESWT for AT leading to uncertainty amongst clinicians on whether ESWT may provide a potential benefit to patients. A recent review (96) seeks to answer the question of ESWT effectiveness for AT, but its methodology needs to be revised. The statistical method used was the fixed model, which does not account for differences in the distribution of effect sizes between studies or participant characteristics and treatment protocols. In addition, the study also included both RCTs and non-RCT trials, which likely led to poor internal validity studies that may have over or under-estimated the actual effect of ESWT for AT; hence an updated review is needed to address these flaws and to provide high-quality evidence.

Additionally, PF faces some similar challenges as AT. Previous guidelines did not recommend ESWT as a form of treatment for PF (18); however, recent guidelines do recommend ESWT for PF (19). The recent review for PF (25) did not provide estimates of the treatment effect magnitude and used a fixed statistical model, which can potentially over or under-estimate the true effect of the intervention (97); hence an updated systematic review quantifying the effectiveness and providing a GRADE quality assessment is essential in addressing this issue.

4.3 Implication of results

ESWT is a common modality used in clinical practice to treat musculoskeletal overuse injuries such as tendinopathies and fasciopathies due to its theorized mechanism for healing degenerated soft tissue (, 19). Our study discovered these novel findings for the effectiveness of ESWT in PT, AT, and PF. ESWT had beneficial short-term effects on pain and function for PT and AT; however, the estimated effects were small and pooled from low to moderate quality evidence, so ESWT should not be used as a primary treatment for modulating pain and function outcomes for PT and AT but as an adjunct in context-specific situations with known treatments that can provide a meaningful change to the patient. On the other hand, ESWT had a large estimated effects on PF in the short to long term, which were pooled from high quality evidence; hence ESWT can be provided as primary treatment for patients with PF.

4.4 Recommendations

The majority of the current literature reports on the short-term effectiveness of ESWT for PT, AT, and PF, so future studies with large sample sizes and placebo controls should focus on the efficacy of ESWT in the long term on changing pain and function outcomes in a diverse population. Moreover, future studies should also focus on creating and using a standardized ESWT treatment protocol. In addition, studies evaluating the potential adverse event for ESWT application in PT, AT, and PF are needed.

4.5 Limitations

This study had several limitations. First, due to the limited number of included studies in the analysis, the results must be interpreted cautiously because none of our analyses had ten or more studies; hence the results may not accurately represent the true estimated effect for the population (98). Second, Only English and Chinese databases were searched. This could have left out other vital trials relevant to the topic published in other languages. Third, the significance of the heterogeneity observed in the analysis could not be appropriately explained due to the few numbers of included studies.

5 Conclusion

In conclusion, there is a negligible effect with a low to moderate certainty of evidence that ESWT can improve function and reduce pain in the short term for PT and AT. However, ESWT had a large effect with a high certainty of evidence in improving function and reducing pain in the short-term, mid-term, and long-term for PF.

Statements

Data availability statement

The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be directed to the corresponding author.

Author contributions

RC: protocol design, data collection, extraction, writing, and editing. LF: protocol design, risk of bias assessment, GRADE assessment, data collection, and extraction and reviewing. RZ: risk of bias assessment, data collection and extraction, and GRADE assessment. JW: data interpretation, risk of bias assessment, GRADE assessment, and analysis. All authors contributed to the article and approved the submitted version.

Funding

This study was supported by the Three-year Action Plan for the Development of TCM in the Shanghai-Highland Construction for International Standardization of TCM (No. ZY(2021–2023)-0212).

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Supplementary material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1193835/full#supplementary-material

References

  • 1

    HopkinsCFuS-CEldrichCHuXRolfCVilleMet al. Critical review on the socio-economic impact of tendinopathy. Asia-Pacific J Sports Med Arthroscopy Rehabil Technol (2016) 4(April 2016):9–20. doi: 10.1016/j.asmart.2016.01.002

  • 2

    MillarNLSilbernagelKGThorborgKKirwanPDGalatzLMAbramsGDet al. Tendinopathy. Nat Rev Dis Primers (2021) 7(1). doi: 10.1038/s41572-020-00234-1

  • 3

    RielHLindstrømCFRathleffMSJensenMBOlesenJL. Prevalence and incidence rate of lower-extremity tendinopathies in a danish general practice: A registry-based study. BMC Musculoskeletal Disord (2019) 20(1):239. doi: 10.1186/s12891-019-2629-6

  • 4

    KingDYakubekGChughtaiMKhlopasASaluanPMontMAet al. Quadriceps tendinopathy: A review—Part 1: epidemiology and diagnosis. Ann Trans Med (2019) 7(4):71–1. doi: 10.21037/atm.2019.01.58

  • 5

    RudavskyACookJ. Physiotherapy management of patellar tendinopathy (Jumper’s knee). J Physiother (2014) 60(3):122–29. doi: 10.1016/j.jphys.2014.06.022

  • 6

    ScottASquierKAlfredsonHBahrRCookJLCoombesBet al. ICON 2019: international scientific tendinopathy symposium consensus: clinical terminology. Br J Sports Med (2020) 54(5):260–62. doi: 10.1136/bjsports-2019-100885

  • 7

    HägglundMZwerverJEkstrandJ. Epidemiology of patellar tendinopathy in elite male soccer players. Am J Sports Med (2011) 39(9):1906–11. doi: 10.1177/0363546511408877

  • 8

    CookJLKhanKMKissZSGriffithsL. Patellar tendinopathy in junior basketball players: A controlled clinical and ultrasonographic study of 268 patellar tendons in players aged 14-18 years: patellar tendinopathy in junior basketball players. Scandinavian J Med Sci Sports (2000) 10(4):216–20. doi: 10.1034/j.1600-0838.2000.010004216.x

  • 9

    SilbernagelKGHanlonSSpragueA. Current clinical concepts: conservative management of achilles tendinopathy. J Athletic Training (2020) 55(5):438–47. doi: 10.4085/1062-6050-356-19

  • 10

    De VosR-Jvan der VlistACZwerverJMeuffelsDESmithuisFVan IngenRet al. Dutch multidisciplinary guideline on achilles tendinopathy. Br J Sports Med (2021) 55(20):1125–34. doi: 10.1136/bjsports-2020-103867

  • 11

    De JongeSVan Den BergCDe VosRJvan der HeideHJLWeirAVerhaarJANet al. Incidence of midportion achilles tendinopathy in the general population. Br J Sports Med (2011) 45(13):1026–28. doi: 10.1136/bjsports-2011-090342

  • 12

    KujalaUMSarnaSKaprioJ. Cumulative incidence of achilles tendon rupture and tendinopathy in male former elite athletes. Clin J Sport Med (2005) 15(3):133–35. doi: 10.1097/01.jsm.0000165347.55638.23

  • 13

    McPoilTGMartinRLCornwallMWWukichDKIrrgangJJGodgesJJ. Heel pain—Plantar fasciitis. J Orthop Sports Phys Ther (2008) 38(4):A1–18. doi: 10.2519/jospt.2008.0302

  • 14

    DunnJE. Prevalence of foot and ankle conditions in a multiethnic community sample of older adults. Am J Epidemiol (2004) 159(5):491–98. doi: 10.1093/aje/kwh071

  • 15

    HillCLGillTKMenzHBTaylorAW. Prevalence and correlates of foot pain in a population-based study: the north west adelaide health study. J Foot Ankle Res (2008) 1(1):2. doi: 10.1186/1757-1146-1-2

  • 16

    TauntonJE. A retrospective case-control analysis of 2002 running injuries. Br J Sports Med (2002) 36(2):95–101. doi: 10.1136/bjsm.36.2.95

  • 17

    Hamstra-WrightKLHuxel BlivenKCCurtis BayRAydemirB. Risk factors for plantar fasciitis in physically active individuals: A systematic review and meta-analysis. Sports Health: A Multidiscip Approach (2021) 13(3):296–303. doi: 10.1177/1941738120970976

  • 18

    MartinRLDavenportTEReischlSFMcPoilTGMathesonJWWukichDKet al. Heel pain—Plantar fasciitis: revision 2014. J Orthop Sports Phys Ther (2014) 44(11):A1–33. doi: 10.2519/jospt.2014.0303

  • 19

    MorrisseyDCotchettMSaid J’BariAPriorTGriffithsIBRathleffMSet al. Management of plantar heel pain: A best practice guide informed by a systematic review, expert clinical reasoning and patient values. Br J Sports Med (2021) 55(19):1106–18. doi: 10.1136/bjsports-2019-101970

  • 20

    KorakakisVWhiteleyRTzavaraAMalliaropoulosN. The effectiveness of extracorporeal shockwave therapy in common lower limb conditions: A systematic review including quantification of patient-rated pain reduction. Br J Sports Med (2018) 52(6):387–407. doi: 10.1136/bjsports-2016-097347

  • 21

    Mani-BabuSMorrisseyDWaughCScreenHBartonC. The effectiveness of extracorporeal shock wave therapy in lower limb tendinopathy: A systematic review. Am J Sports Med (2015) 43(3):752–61. doi: 10.1177/0363546514531911

  • 22

    MartinRLChimentiRCuddefordTHouckJMathesonJWMcDonoughCMet al. Achilles pain, stiffness, and muscle power deficits: midportion achilles tendinopathy revision 2018: clinical practice guidelines linked to the international classification of functioning, disability and health from the orthopaedic section of the American physical therapy association. J Orthop Sports Phys Ther (2018) 48(5):A1–38. doi: 10.2519/jospt.2018.0302

  • 23

    BariliFParolariAKappeteinPAFreemantleN. Statistical primer: heterogeneity, random- or fixed-effects model analyses? Interactive Cardiovasc Thorac Surg (2018) 27(3):317–21. doi: 10.1093/icvts/ivy163

  • 24

    LiHXiongYZhouWLiuYLiuJXueHet al. Shock-wave therapy improved outcome with plantar fasciitis: A meta-analysis of randomized controlled trials. Arch Orthop Trauma Surg (2019) 139(12):1763–70. doi: 10.1007/s00402-019-03262-z

  • 25

    XiongYWuQMiBZhouWLiuYLiuJet al. Comparison of efficacy of shock-wave therapy versus corticosteroids in plantar fasciitis: A meta-analysis of randomized controlled trials. Arch Orthop Trauma Surg (2019) 139(4):529–36. doi: 10.1007/s00402-018-3071-1

  • 26

    PageMJMcKenzieJEBossuytPMBoutronIHoffmannTCMulrowCDet al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ (2021), n71. doi: 10.1136/bmj.n71

  • 27

    SterneJACSavovićJPageMJElbersRGBlencoweNSBoutronIet al. RoB 2: A revised tool for assessing risk of bias in randomised trials. BMJ (2019), l4898. doi: 10.1136/bmj.l4898

  • 28

    BrożekJLAklEAAlonso-CoelloPLangDJaeschkeRWilliamsJWet al. Grading quality of evidence and strength of recommendations in clinical practice guidelines. Allergy (2009) 64(5):669–77. doi: 10.1111/j.1398-9995.2009.01973.x

  • 29

    HigginsJPTCochrane Collaboration. Cochrane Handbook for Systematic Reviews of Interventions. In: Cochrane Book Series, 2nd ed. Hoboken, NJ: Wiley-Blackwell (2020).

  • 30

    CohenJ. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Hoboken: Taylor and Francis (2013).

  • 31

    HigginsJPT. Measuring inconsistency in meta-analyses. BMJ (2003) 327(7414):557–60. doi: 10.1136/bmj.327.7414.557

  • 32

    TauntonJTauntonKKhanK. Treatment of patellar tendinopathy with extracorporeal shock wave therapy. BC Med J (2003) 45(10).

  • 33

    ZwerverJHartgensFVerhagenEvan der WorpHVan Den Akker-ScheekIDiercksRL. No effect of extracorporeal shockwave therapy on patellar tendinopathy in jumping athletes during the competitive season: A randomized clinical trial. Am J Sports Med (2011) 39(6):1191–99. doi: 10.1177/0363546510395492

  • 34

    ZhangZJLeeWCFuSN. One session of extracorporeal shockwave therapy-induced modulation on tendon shear modulus is associated with reduction in pain. J Sports Sci Med (2020) 19:309–16.

  • 35

    Persson KroghTAstrupJKKyedCFredbergU. Extracorporeal shockwave therapy in the treatment of patellar tendinopathy: A randomized, double-blind, placebo-controlled trial. Trans Sports Med (2021) 4(4):534–44. doi: 10.1002/tsm2.246

  • 36

    ThijsKMZwerverJBackxFJGSteenekenVRayerSGroenenboomPet al. Effectiveness of shockwave treatment combined with eccentric training for patellar tendinopathy: A double-blinded randomized study. Clin J Sport Med (2017) 27(2):89–96. doi: 10.1097/JSM.0000000000000332

  • 37

    LeeW-CNgGY-FZhangZ-JMalliarasPMasciLFuS-N. Changes on tendon stiffness and clinical outcomes in athletes are associated with patellar tendinopathy after eccentric exercise. Clin J Sport Med Publish Ahead Print (2007). 46(5):348–357. doi: 10.1097/JSM.0000000000000562

  • 38

    ChengLChangSQianLWangYYangM. Extracorporeal shock wave therapy for isokinetic muscle strength around the knee joint in athletes with patellar tendinopathy. J Sports Med Phys Fitness (2019) 59(5). doi: 10.23736/S0022-4707.18.09023-0

  • 39

    WangC-JKoJ-YChanY-SWengL-HHsuS-L. Extracorporeal shockwave for chronic patellar tendinopathy. Am J Sports Med (2007) 35(6):972–78. doi: 10.1177/0363546506298109

  • 40

    Van Der WorpHZwerverJHamstraMVan Den Akker-ScheekIDiercksRL. No difference in effectiveness between focused and radial shockwave therapy for treating patellar tendinopathy: A randomized controlled trial. Knee Surg Sports Traumatol Arthroscopy (2014) 22(9):2026–32. doi: 10.1007/s00167-013-2522-z

  • 41

    VetranoMCastorinaAVulpianiMCBaldiniRPavanAFerrettiA. Platelet-rich plasma versus focused shock waves in the treatment of jumper’s knee in athletes. Am J Sports Med (2013) 41(4):795–803. doi: 10.1177/0363546513475345

  • 42

    AbdelkaderNAHelmyMNKFayazNASaweeresESB. Short- and intermediate-term results of extracorporeal shockwave therapy for noninsertional achilles tendinopathy. Foot Ankle Int (2021) 42(6):788–97. doi: 10.1177/1071100720982613

  • 43

    Demir BenliMTatariHBalcıAPekerAŞimşekKYükselOet al. A comparison between the efficacy of eccentric exercise and extracorporeal shock wave therapy on tendon thickness, vascularity, and elasticity in achilles tendinopathy: A randomized controlled trial. Turkish J Phys Med Rehabil (2022) 68(3):372–80. doi: 10.5606/tftrd.2022.8113

  • 44

    GatzMSchwedaSBetschMDirrichsTde laFuenteMReinhardtNet al. Line- and point-focused extracorporeal shock wave therapy for achilles tendinopathy: A placebo-controlled RCT study. Sports Health: A Multidiscip Approach (2021) 13(5):511–18. doi: 10.1177/1941738121991791

  • 45

    VahdatpourBForouzanHMomeniFAhmadiMTaheriP. Effectiveness of extracorporeal shockwave therapy for chronic achilles tendinopathy: A randomized clinical trial. J Res Med Sci (2018) 23(1):37. doi: 10.4103/jrms.JRMS_413_16

  • 46

    LynenNDe VroeyTSpiegelIOngevalFVHendrickxN-JStassijnsG. Comparison of peritendinous hyaluronan injections versus extracorporeal shock wave therapy in the treatment of painful achilles’ Tendinopathy: A randomized clinical efficacy and safety study. Arch Phys Med Rehabil (2017) 98(1):64–71. doi: 10.1016/j.apmr.2016.08.470

  • 47

    NotarnicolaAMaccagnanoGTafuriSForcignanòMIPanellaAMorettiB. CHELT therapy in the treatment of chronic insertional achilles tendinopathy. Lasers Med Sci (2014) 29(3):1217–25. doi: 10.1007/s10103-013-1510-3

  • 48

    RasmussenSChristensenMMathiesenISimonsonO. Shockwave therapy for chronic achilles tendinopathy: A double-blind, randomized clinical trial of efficacy. Acta Orthop (2008) 79(2):249–56. doi: 10.1080/17453670710015058

  • 49

    RompeJDNafeBFuriaJPMaffulliN. Eccentric loading, shock-wave treatment, or a wait- and-see policy for tendinopathy of the main body of tendo achillis: A randomized controlled trial. Am J Sports Med (2007) 35(3):374–83. doi: 10.1177/0363546506295940

  • 50

    RompeJDFuriaJMaffulliN. Eccentric loading compared with shock wave treatment for chronic insertional achilles tendinopathy: A randomized, controlled trial. J Bone Joint Surgery-American (2008) 90(1):52–61. doi: 10.2106/JBJS.F.01494

  • 51

    RompeJDFuriaJMaffulliN. Eccentric Loading versus Eccentric Loading plus Shock-Wave Treatment for Midportion Achilles Tendinopathy: A Randomized Controlled Trial. Am J Sports Med (2009) 37(3):463–70. doi: 10.1177/0363546508326983

  • 52

    CostaMLShepstoneLDonellSTThomasTL. Shock wave therapy for chronic achilles tendon pain: A randomized placebo-controlled trial. Clin Orthop related Res (2005) 440:199–204. doi: 10.1097/01.blo.0000180451.03425.48

  • 53

    MansurNSBMatsunagaFTCarrazzoneOLSchiefer Dos SantosBNunesCGAoyamaBTet al. Shockwave therapy plus eccentric exercises versus isolated eccentric exercises for achilles insertional tendinopathy: A double-blinded randomized clinical trial. J Bone Joint Surg (2021) 103(14):1295–302. doi: 10.2106/JBJS.20.01826

  • 54

    PinitkwamdeeSLaohajaroensombatSOrapinJWoratanaratP. Effectiveness of extracorporeal shockwave therapy in the treatment of chronic insertional achilles tendinopathy. Foot Ankle Int (2020) 41(4):403–10. doi: 10.1177/1071100719898461

  • 55

    Armagan AlpturkerKCerrahogluABLOrgucIS. Evaluation effects of laser therapy and extracorporeal shock wave therapy with clinical parameters and magnetic resonance imaging for treatment of plantar fasciitis in patients with spondyloarthritis: A randomized controlled trial. Int J Rheumatol (2020) 2020:1–8. doi: 10.1155/2020/4386361

  • 56

    AsheghanMHashemiSEHollisazMTRoumizadePHosseiniSMGhanjalA. Dextrose prolotherapy versus radial extracorporeal shock wave therapy in the treatment of chronic plantar fasciitis: A randomized, controlled clinical trial. Foot Ankle Surg (2021) 27(6):643–49. doi: 10.1016/j.fas.2020.08.008

  • 57

    BagcierFYilmazN. The impact of extracorporeal shock wave therapy and dry needling combination on pain and functionality in the patients diagnosed with plantar fasciitis. J Foot Ankle Surg (2020) 59(4):689–93. doi: 10.1053/j.jfas.2019.09.038

  • 58

    Bahar-OzdemirYAtanT. Effects of adjuvant low-dye kinesio taping, adjuvant sham taping, or extracorporeal shockwave therapy alone in plantar fasciitis: A randomised double-blind controlled trial. Int J Clin Pract (2021) 75(5). doi: 10.1111/ijcp.13993

  • 59

    BuchbinderRPtasznikRGordonJBuchananJPrabaharanVForbesA. Ultrasound-guided extracorporeal shock wave therapy for plantar fasciitis: A randomized controlled trial. JAMA (2002) 288(11):1364. doi: 10.1001/jama.288.11.1364

  • 60

    CanerÖCGüneşSGökmenDAtamanŞKutlayŞ. The efficacy and safety of extracorporeal shock wave therapy on plantar fasciitis in patients with axial spondyloarthritis: A double-blind, randomized controlled trial. Rheumatol Int (2022) 42(4):581–89. doi: 10.1007/s00296-022-05098-0

  • 61

    ChewKTLLeongDLinCYLimKKTanB. Comparison of autologous conditioned plasma injection, extracorporeal shockwave therapy, and conventional treatment for plantar fasciitis: A randomized trial. PM&R (2013) 5(12):1035–43. doi: 10.1016/j.pmrj.2013.08.590

  • 62

    CinarESaxenaSUygurF. Combination therapy versus exercise and orthotic support in the management of pain in plantar fasciitis: A randomized controlled trial. Foot Ankle Int (2018) 39(4):406–14. doi: 10.1177/1071100717747590

  • 63

    CinarESaxenaSAkkurtHEUygurF. Extracorporeal shockwave therapy in the management of plantar fasciitis: A randomized controlled trial. Foot (2020) 44:101679. doi: 10.1016/j.foot.2020.101679

  • 64

    Yinilmez SanmakÖD. Comparison of effects of low-level laser therapy and extracorporeal shock wave therapy in plantar fasciitis treatment: A randomized, prospective, single-blind clinical study. Turkish J Phys Med Rehabil (2019) 65(2):184–90. doi: 10.5606/tftrd.2019.3528

  • 65

    XuDJiangWHuangDHuXWangYLiHet al. Comparison between extracorporeal shock wave therapy and local corticosteroid injection for plantar fasciitis. Foot Ankle Int (2020) 41(2):200–5. doi: 10.1177/1071100719891111

  • 66

    EslamianFShakouriSKJahanjooFHajialilooMNotghiF. Extra corporeal shock wave therapy versus local corticosteroid injection in the treatment of chronic plantar fasciitis, a single blinded randomized clinical trial. Pain Med (2016) 17(9):1722–31. doi: 10.1093/pm/pnw113

  • 67

    GerdesmeyerLFreyCVesterJMaierMLowellWWeilLet al. Radial extracorporeal shock wave therapy is safe and effective in the treatment of chronic recalcitrant plantar fasciitis: results of a confirmatory randomized placebo-controlled multicenter study. Am J Sports Med (2008) 36(11):2100–9. doi: 10.1177/0363546508324176

  • 68

    GollwitzerHDiehlPKorffAVRahlfsVWGerdesmeyerL. Extracorporeal shock wave therapy for chronic painful heel syndrome: A prospective, double blind, randomized trial assessing the efficacy of a new electromagnetic shock wave device. J Foot Ankle Surg (2007) 46(5):348–57. doi: 10.1053/j.jfas.2007.05.011

  • 69

    GollwitzerHSaxenaADiDomenicoLAGalliLBouchéRTCaminearDSet al. Clinically relevant effectiveness of focused extracorporeal shock wave therapy in the treatment of chronic plantar fasciitis: A randomized, controlled multicenter study. J Bone Joint Surgery-American (2015) 97(9):701–8. doi: 10.2106/JBJS.M.01331

  • 70

    HaakeM. Extracorporeal shock wave therapy for plantar fasciitis: randomised controlled multicentre trial. BMJ (2003) 327(7406):75–0. doi: 10.1136/bmj.327.7406.75

  • 71

    IbrahimMIDonatelliRASchmitzCHellmanMABuxbaumF. Chronic plantar fasciitis treated with two sessions of radial extracorporeal shock wave therapy. Foot Ankle Int (2010) 31(5):391–97. doi: 10.3113/FAI.2010.0391

  • 72

    IbrahimMIDonatelliRAHellmanMHusseinAZFuriaJPSchmitzC. Long-term results of radial extracorporeal shock wave treatment for chronic plantar fasciopathy: A prospective, randomized, placebo-controlled trial with two years follow-up: RADIAL ESWT FOR PLANTAR FASCIOPATHY. J Orthop Res (2017) 35(7):1532–38. doi: 10.1002/jor.23403

  • 73

    KesikburunSŞanAUKesikburunBArasBYaşarETanAK. Comparison of ultrasound-guided prolotherapy versus extracorporeal shock wave therapy in the treatment of chronic plantar fasciitis: A randomized clinical trial. J Foot Ankle Surg (2022) 61(1):48–52. doi: 10.1053/j.jfas.2021.06.007

  • 74

    KudoPDaintyKClarfieldMCoughlinLLavoiePLebrunC. Randomized, placebo-controlled, double-blind clinical trial evaluating the treatment of plantar fasciitis with an extracoporeal shockwave therapy (ESWT) device: A north american confirmatory study. J Orthop Res (2006) 24(2):115–23. doi: 10.1002/jor.20008

  • 75

    LaiT-WLiHLeeM-SChenP-MKuM-CLaiT-W. Ultrasonography and clinical outcome comparison of extracorporeal shock wave therapy and corticosteroid injections for chronic plantar fasciitis: A randomized controlled trial. J Musculoskeletal Neuronal Interact (2017) 18:47–54. doi: 10.1053/j.jfas.2006.04.007

  • 76

    MalayDSPressmanMMAssiliAKlineJTYorkSBurenBet al. Extracorporeal shockwave therapy versus placebo for the treatment of chronic proximal plantar fasciitis: results of a randomized, placebo-controlled, double-blinded, multicenter intervention trial. J Foot Ankle Surg (2006) 45(4):196–210. doi: 10.1053/j.jfas.2006.04.007

  • 77

    Mardani-KiviMMobarakehMKHassanzadehZMirbolookAAsadiKEttehadHet al. Treatment outcomes of corticosteroid injection and extracorporeal shock wave therapy as two primary therapeutic methods for acute plantar fasciitis: A prospective randomized clinical trial. J Foot Ankle Surg (2015) 54(6):1047–52. doi: 10.1053/j.jfas.2015.04.026

  • 78

    UğurlarMSönmezMMUğurlarÖYAdıyekeLYıldırımHErenOT. Effectiveness of four different treatment modalities in the treatment of chronic plantar fasciitis during a 36-month follow-up period: A randomized controlled trial. J Foot Ankle Surg (2018) 57(5):913–18. doi: 10.1053/j.jfas.2018.03.017

  • 79

    OrdahanB. Extracorporeal shockwave therapy versus kinesiology taping in the management of plantar fasciitis: A randomized clinical trial. Arch Rheumatol (2017) 32(3):227–33. doi: 10.5606/ArchRheumatol.2017.6059

  • 80

    PorterMDShadboltB. Intralesional corticosteroid injection versus extracorporeal shock wave therapy for plantar fasciopathy. Clin J Sport Med (2005) 15(3):119–24. doi: 10.1097/01.jsm.0000164039.91787.dc

  • 81

    RahbarMEslamianFToopchizadehVJahanjooFKargarADolatkhahN. A comparison of the efficacy of dry-needling and extracorporeal shockwave therapy for plantar fasciitis: a randomized clinical trial. Iran Red Crescent Med J (2018) 20(9):e68908. doi: 10.5812/ircmj.68908

  • 82

    RazzanoCCarboneSMangoneMIannottaMRBattagliaASantilliV. Treatment of chronic plantar fasciitis with noninvasive interactive neurostimulation: A prospective randomized controlled study. J Foot Ankle Surg (2017) 56(4):768–72. doi: 10.1053/j.jfas.2017.02.015

  • 83

    RocaBMendozaMARocaM. Comparison of extracorporeal shock wave therapy with botulinum toxin type A in the treatment of plantar fasciitis. Disability Rehabil (2016) 38(21):2114–21. doi: 10.3109/09638288.2015.1114036

  • 84

    RompeJDDeckingJSchoellnerCNafeB. Shock wave application for chronic plantar fasciitis in running athletes: A prospective, randomized, placebo-controlled trial. Am J Sports Med (2003) 31(2):268–75. doi: 10.1177/03635465030310021901

  • 85

    RompeJMeurerANafeBHofmannAGerdesmeyerL. Repetitive Low-Energy Shock Wave Application without Local Anesthesia Is More Efficient than Repetitive Low-Energy Shock Wave Application with Local Anesthesia in the Treatment of Chronic Plantar Fasciitis. J Orthop Res (2005) 23(4):931–41. doi: 10.1016/j.orthres.2004.09.003

  • 86

    RompeJDCacchioAWeilLFuriaJPHaistJReinersVet al. Plantar fascia-specific stretching versus radial shock-wave therapy as initial treatment of plantar fasciopathy. J Bone Joint Surgery-American (2010) 92(15):2514–22. doi: 10.2106/JBJS.I.01651

  • 87

    RompeJDFuriaJCacchioASchmitzCMaffulliN. Radial shock wave treatment alone is less efficient than radial shock wave treatment combined with tissue-specific plantar fascia-stretching in patients with chronic plantar heel pain. Int J Surg (2015) 24:135–42. doi: 10.1016/j.ijsu.2015.04.082

  • 88

    OkurSAydınA. Comparison of extracorporeal shock wave therapy with custom foot orthotics in plantar fasciitis treatment: A prospective randomized one-year follow-up study. J Musculoskeletal Neuronal Interact (2019) 18:178–86.

  • 89

    SpeedCANicholsDWiesJHumphreysHRichardsCBurnetSet al. Extracorporeal shock wave therapy for plantar fasciitis. A double blind randomised controlled trial. J Orthop Res (2003) 21(5):937–40. doi: 10.1016/S0736-0266(03)00048-2

  • 90

    TezelNUmayEBulutMCakciA. Short-term efficacy of kinesiotaping versus extracorporeal shockwave therapy for plantar fasciitis: A randomized study. Saudi J Med Med Sci (2020) 8(3):181. doi: 10.4103/sjmms.sjmms_624_19

  • 91

    TheodoreGHBuchMAmendolaABachmannCFlemingLLZingasC. Extracorporeal shock wave therapy for the treatment of plantar fasciitis. Foot Ankle Int (2004) 25(5):290–97. doi: 10.1177/107110070402500503

  • 92

    TimurtaşEÇinarESelçukHAvciEEBatarSDemirbükenİet al. Extracorporeal shock wave therapy versus low level laser therapy in the treatment of plantar fasciitis: A randomized controlled trial. J Am Podiatr Med Assoc (2022), 1–27. doi: 10.7547/22-095

  • 93

    UlusoyACerrahogluLOrgucS. Magnetic resonance imaging and clinical outcomes of laser therapy, ultrasound therapy, and extracorporeal shock wave therapy for treatment of plantar fasciitis: A randomized controlled trial. J Foot Ankle Surg (2017) 56(4):762–67. doi: 10.1053/j.jfas.2017.02.013

  • 94

    YucelIOzturanKEDemiraranYDegirmenciEKaynakG. Comparison of high-dose extracorporeal shockwave therapy and intralesional corticosteroid injection in the treatment of plantar fasciitis. J Am Podiatr Med Assoc (2010) 100(2):105–10. doi: 10.7547/1000105

  • 95

    The International Society for Medical Shockwave Treatment. Available at: https://www.shockwavetherapy.org/fileadmin/user_upload/ISMST_Guidelines.pdf.

  • 96

    PaantjensMAHelmhoutPHBackxFJGVan Etten-JamaludinFSBakkerEWP. Extracorporeal shockwave therapy for mid-portion and insertional achilles tendinopathy: A systematic review of randomized controlled trials. Sports Med - Open (2022) 8(1):68. doi: 10.1186/s40798-022-00456-5

  • 97

    BorensteinMHedgesLVHigginsJPTRothsteinHR. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods (2010) 1(2):97–111. doi: 10.1002/jrsm.12

  • 98

    BorensteinM. Research note: in a meta-analysis, the I index does not tell us how much the effect size varies across studies. J Physiother (2020) 66(2):135–39. doi: 10.1016/j.jphys.2020.02.011

Summary

Keywords

extracorporeal shockwave therapy, patellar tendinopathy, Achilles tendinopathy, tendinopathy, plantar fasciitis

Citation

Charles R, Fang L, Zhu R and Wang J (2023) The effectiveness of shockwave therapy on patellar tendinopathy, Achilles tendinopathy, and plantar fasciitis: a systematic review and meta-analysis. Front. Immunol. 14:1193835. doi: 10.3389/fimmu.2023.1193835

Received

25 March 2023

Accepted

28 July 2023

Published

16 August 2023

Volume

14 - 2023

Edited by

Howe Liu, Allen College, United States

Reviewed by

Xuan Zhang, Hong Kong Baptist University, Hong Kong SAR, China; Juan Li, Chengdu University of Traditional Chinese Medicine, China

Updates

Copyright

*Correspondence: Lei Fang,

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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