In the published article, there were errors in Figure 2 and its legend. In the published article, parts A –C of Figure 2 for AQP4-ON patient should be consistent with the course of MOG-ON patient for one month. The corrected Figure 2 and its legend appear below.
Figure 2
In the published article, there was an error in Table 2. In the published article, the unit of AQP4-IgG titer should be u/ml. The initial letter of the content of M8 patients should be capitalized, and the antibody titer result should be 1:100 instead of 1; 100. The corrected Table 2 and its captions are listed below.
Table 2
| Patient ID | Age(years) | Sex | Antibody titer | Affected eyes | Therapeutic methods | BCVA at diagnosis | Last follow-up BCVA |
|---|---|---|---|---|---|---|---|
| A1 | 71 | Female | AQP4-IgG:>80u/ml | Right | IVMP and oral prednisolone | 3.5 | 3.5 |
| A2 | 45 | Female | AQP4-IgG:10.37u/ml | Left | Oral prednisolone | 1.7 | 2 |
| A3 | 11 | Female | AQP4-IgG:67.90u/ml | Right | IVMP and oral prednisolone | 2 | 0.4 |
| A4 | 43 | Female | AQP4-IgG:40.83u/ml | Right | None | 0.6 | 0 |
| A5 | 32 | Female | AQP4-IgG:>80u/ml | Right | IVMP and oral prednisolone | 2.5 | 0.2 |
| A6 | 25 | Female | AQP4-IgG:26.8u/ml | Left | IVMP and oral prednisolone | 2.5 | 0.4 |
| M1 | 18 | Male | MOG-IgG:1:10 | Left | IVMP and oral prednisolone | 0.4 | 0.2 |
| M2 | 32 | Female | MOG-IgG:1:10 | Left | IVMP and oral prednisolone | 0.5 | 0.1 |
| M3 | 57 | Female | MOG-IgG:1:10 | Left | IVMP and oral prednisolone | 1.1 | 0.4 |
| M4 | 24 | Female | MOG-IgG:1:100 | Left | IVMP and oral prednisolone | 1.1 | 0.2 |
| M5 | 39 | Female | MOG-IgG:1:10 | Right | IVMP and oral prednisolone | 2 | 0 |
| M6 | 70 | Female | MOG-IgG:1:100 | Left | IVMP and oral prednisolone | 2 | 0.1 |
| M7 | 35 | Male | MOG-IgG:1:32 | Right | IVMP and oral prednisolone | 2 | 0.9 |
| M8 | 31 | Male | MOG-IgG:1:100 | Right | IVMP and oral prednisolone | 0.5 | 0.2 |
Treatment and prognosis of patients.
In the published article, there was an error in the description of Figure 3B.
A correction was made to the Results, Overview of RNA-Seq data and differential gene expression profiles (Paragraph 3.2). This sentence was previously stated as follows:
“[Venn diagram showed that there were 10 co-expressed genes among the three groups, 924 unique genes in the AQP4-ON group and 502 unique genes in the MOG-ON group (Figure 3B).]”
Figure 3
The corrected sentence is as follows:
“[Venn diagram showed that there were five co-expressed genes among the three groups, 517 unique genes in the AQP4-ON group and 1,198 unique genes in the MOG-ON group (Figure 3B).]”
A further correction has been made in the Discussion section, [Paragraph 4]. This sentence was previously stated as follows:
“[Currently, most researchers in the field believe that although MOG-ON is similar to AQP4-ON in clinical manifestations, unlike AQP4-ON, MOG-ON is not an immune subtype of neuromyelitis optical spectrum disorder (NMOSD), but a subtype of MOG antibody-related diseases (MOGAD).]”
The corrected sentence is as follows:
“[Currently, most researchers in the field believe that although MOG-ON is similar to AQP4-ON in clinical manifestations, unlike AQP4-ON, MOG-ON is not an immune subtype of neuromyelitis optica spectrum disorder (NMOSD), but a subtype of MOG antibody-related diseases (MOGAD).]”
In the published article, there was an error. [AQP4-IgG titer unit should be u/ml].
A correction was made to [Materials and methods and Results], [Subjects and samples and Correlation between immune cell infiltration and clinical outcomes], [Paragraphs 2.1 and 3.5]. This sentence was previously stated as follows:
“[For high sensitivity and absolute specificity, the AQP4-IgG was measured using an enzyme-linked immunosorbent assay (ELISA) kit (RSR Ltd., Cardiff, UK) according to the previous study (12) and results 3.0 m/ml were considered as positive.
The AQP4-IgG titer of patient A2 was only 10.37 μ/ml; however, despite the IVMP and oral prednisolone treatment, her vision was still very poor.]”
The corrected sentence is as follows:
“[For high sensitivity and absolute specificity, the AQP4-IgG was measured using an enzyme-linked immunosorbent assay (ELISA) kit (RSR Ltd., Cardiff, UK) according to the previous study (12) and results 3.0 u/mL were considered as positive.
The AQP4-IgG titer of patient A2 was only 10.37 u/ml; however, despite the IVMP and oral prednisolone treatment, her vision was still very poor.]”
In the published article there was an error in the Ethics section. Due to potentially identifiable data included in the article, the following sentence has been included - “Written informed consent was obtained from the [individual(s) AND/OR minor(s)’ legal guardian/next of kin] for the publication of any potentially identifiable images or data included in this article.”
The new Ethics statement appears below.
Statements
Ethics statement
The studies involving human participants were reviewed and approved by The ethics committee of the Affiliated Wuxi Clinical College of Nantong University. Written informed consent to participate in this study was provided by the participants’ legal guardian/next of kin. Written informed consent was obtained from the [individual(s) AND/OR minor(s)’ legal guardian/next of kin] for the publication of any potentially identifiable images or data included in this article.
The authors apologize for these errors and state that these do not change the scientific conclusions of the article in any way. The original manuscript has been updated accordingly.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
optic neuritis, aquaporin 4, myelin oligodendrocyte glycoprotein, RNA-Seq, toll-like receptors
Citation
Chen X, Cheng L, Pan Y, Chen P, Luo Y, Li S, Zou W and Wang K (2023) Corrigendum: Different immunological mechanisms between AQP4 antibody-positive and MOG antibody-positive optic neuritis based on RNA sequencing analysis of whole blood. Front. Immunol. 14:1201718. doi: 10.3389/fimmu.2023.1201718
Received
07 April 2023
Accepted
27 June 2023
Published
15 August 2023
Volume
14 - 2023
Edited and reviewed by
Hans-Peter Hartung, Heinrich Heine University of Düsseldorf, Germany
Updates
Copyright
© 2023 Chen, Cheng, Pan, Chen, Luo, Li, Zou and Wang.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Wenjun Zou, wenjunzou2022@163.com; Ke Wang, wangke@jsinm.org
†These authors have contributed equally to this work and share first authorship
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.