In the published article, there was an error in Table 3 as published. Under the heading C3, rowc.4030-4C>G was under the ACMG classification stated as “P” when it should be “LB”. Under the heading CFHR2, row R141S, “c.423G>A” should have been written as “c.423G>T”. And finally, under the heading CLU, row K444Q, “c.1339A>C” should be corrected to “c.1330A>C”. The corrected Table 3 and its caption appear below.
Table 3
| Variant or deletion | Nucleotide shift | Type of variant | dbSNP | Domain | Minor Allele frequency | Functional studies | ACMG classification | Reference | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CFH | |||||||||||
| D693N a | c.2077G>A | Missense | rs148403790 | SCR12 | 0.0001592 | Conflicting | (48) | ||||
| Q950H | c.2850G>T | Missense | rs149474608 | SCR16 | 0.003911 | NPE | LP | (45, 51) | |||
| N1050Yb | c.3148A>T | Missense | rs35274867 | SCR18 | 0.01469 | NPE | LB | (45, 54) | |||
| S1209T | c.3625T>A | Missense | rs561146868 | SCR20 | 0.00000398 | – | LB | (48) | |||
| C3 | |||||||||||
| K155Q | c.463A>C | Missense | rs147859257 | MG2 | 0.002705 | GoF | LP | (58, 59) | |||
| V326Mc | c.976G>A | Missense | rs375264020 | MG3 | 0.00004779 | – | VUS | This study | |||
| Q1061H | c.3183A>T | Missense | rs373054812 | TED | 0.00007704 | – | VUS | This study | |||
| E1516A | c.4547A>C | Missense | rs1019532370 | C345C | 0.00001193 | – | VUS | This study | |||
| W1631* | c.4893G>A | Stop | NA | C345C | – | LoF | P | (61) | |||
| c.4030-4C>G | Splice acceptor site | NA | Between CUB and MG8 | – | – | LB | (55) | ||||
| CFI | |||||||||||
| c.1534+5G>T | Intronic splice | rs114013791 | Intron 12 | 0.00866 | – | – | (33) | ||||
| G328R | c.981G>A | Missense | rs144164794 | Linker 2 | – | LoF | LP | (55, 65) | |||
| CD46 | |||||||||||
| A353Va,b | c.1013C>T | Missense | rs35366573 | TM | 0.01541 | LoF, NFE | Conflicting | (33, 73) | |||
| C5 | |||||||||||
| P233L | c.698C>T | Missense | rs531284110 | MG3 | 0.0000252 | – | VUS | (81) | |||
| L354M | c.1060C>A | Missense | rs34552775 | MG4 | 0.0055 | – | B | (82) | |||
| G385R | c.1153G>C | Missense | – | MG4 | Unknown | – | – | This study | |||
| CFHR1 | |||||||||||
| Deletion | Deletion | – | – | LB | (76) | ||||||
| Exon 6 duplication | Duplication | – | LB | This study. Other duplications reported in (83) | |||||||
| CFHR2 | |||||||||||
| R141S | c.423G>T | Missense | rs142929868 | SCR2 | 0.002947 | – | – | This study | |||
| CFHR3 | |||||||||||
| Deletion | Deletion | – | – | – | (76) | ||||||
| CFHR4 | |||||||||||
| Y43Fd | c.128A>T | Missense | rs202234955 | SCR1 | 0.001747 | – | LB | This study | |||
| c.799+3A>C | Intronic splice | Rs196876631 | – | 0.001286 | – | LB | (82) | ||||
| CFHR5 | |||||||||||
| E163Kfs*10 | c.485_486dup | Frameshift (insertion) | rs565457964 | SCR3 | 0.006750 | NPE | – | (77) | |||
| E226Dfs*7 | c.678del | Deletion | rs1438537910 | SCR4 | 0.000007964 | – | P | This study | |||
| Y279N | c.835T>A | Missense | rs143240067 | SCR5 | 0.0001274 | – | Conflicting | (78) | |||
| R356Hb | c.1067G>A | Missense | rs35662416 | SCR6 | 0.01633 | NPE | LB | (77, 84) | |||
| CFP | |||||||||||
| D299N | c.895G>A | Missense | rs61737993 | TSP t1 5 | 0.001472 | – | B | (85) | |||
| CLU | |||||||||||
| K444Q | c.1330A>C | Missense | rs2612311022 | β-chain | 0.0001026 | - | - | This study | |||
| PLG | |||||||||||
| R89K | c.266G>A | Missense | rs143079629 | PAN | 0.006191 | – | B | (48) | |||
| R261H | c.782G>A | Missense | rs4252187 | Kringle 2 | 0.002501 | – | Conflicting | (80) | |||
Variants in C3G patients included in this study.
a, Mentioned in the complement database (www.complement-db.org) with reference to (4). b, Minor allele frequency > 1% but this variant was previously associated with aHUS. c, Previously reported in the ClinVar database in association with age-related macular degeneration and aHUS. d, Previously reported in the ClinVar database in association with aHUS. CFH, Complement factor H; C3, Complement C3; CFB, Complement factor B; CFI, Complement factor I; CD46, CD46/Membrane cofactor protein; C5, Complement C5; CFHR1-5, Complement factor H related 1-5; CFP, Complement factor properdin; PLG, Plasminogen. Domains, SCR, Short consensus repeats; MG1-8, Macroglobulin domain 1-8; TED, Thiol ester-containing domain; C345C, C345C/NTR domain; CUB: C1r/C1s, Urchin embryonic growth factor, Bone morphogenetic protein 1; TM, Transmembrane protein; TSP t1, Thrombospondin type-1 1-5; PAN, Plasminogen-Apple-Nematode; NPE, No phenotypic effect; GoF, Gain of function; LOF, Loss of function (including low plasma concentration); VUS, Variant of unknown significance; LP, Likely pathogenic; LB, Likely benign; P, Pathogenic.
In the published article, there was an error in Supplementary Table 1. The C3 level of patient 314 was given as “normal” when it should have been written as “low”. The corrected Supplementary Material File has now been published.
The authors apologize for these errors and state that they do not change the scientific conclusions of the article in any way. The original article has been updated.
Statements
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
complement, atypical hemolytic uremic syndrome, C3 glomerulopathy, membranoproliferative glomerulonephritis, genes
Citation
Rydberg V, Aradottir SS, Kristoffersson A-C, Svitacheva N and Karpman D (2024) Corrigendum: Genetic investigation of Nordic patients with complement-mediated kidney diseases. Front. Immunol. 15:1476204. doi: 10.3389/fimmu.2024.1476204
Received
05 August 2024
Accepted
08 August 2024
Published
23 August 2024
Volume
15 - 2024
Edited and reviewed by
Francesca Granucci, University of Milano-Bicocca, Italy
Updates
Copyright
© 2024 Rydberg, Aradottir, Kristoffersson, Svitacheva and Karpman.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Diana Karpman, diana.karpman@med.lu.se
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.